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ABL1 ABL1 GRIN1 GRIN1 DLG4 DLG4 CAMK2B CAMK2B RASGRF1 RASGRF1 GRIN2D GRIN2D RASGRF2 RASGRF2 HRAS HRAS CAMK2A CAMK2A CAMK2D CAMK2D CAMK2G CAMK2G
"GRIN2D" - glutamate receptor, ionotropic, N-methyl D-aspartate 2D in Homo sapiens
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protein of unknown 3D structure
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GRIN2Dglutamate receptor, ionotropic, N-methyl D-aspartate 2D; NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine (1336 aa)    
Predicted Functional Partners:
DLG4
discs, large homolog 4 (Drosophila); Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity) (767 aa)
        score_image score_image score_image   0.995
GRIN1
glutamate receptor, ionotropic, N-methyl D-aspartate 1 (943 aa)
        score_image score_image score_image score_image 0.976
RASGRF2
Ras protein-specific guanine nucleotide-releasing factor 2; Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation (1237 aa)
          score_image score_image   0.957
RASGRF1
Ras protein-specific guanine nucleotide-releasing factor 1; Promotes the exchange of Ras-bound GDP by GTP (1273 aa)
          score_image score_image   0.956
CAMK2G
calcium/calmodulin-dependent protein kinase II gamma (556 aa)
        score_image score_image score_image   0.954
CAMK2B
calcium/calmodulin-dependent protein kinase II beta (666 aa)
        score_image score_image score_image   0.953
ABL1
c-abl oncogene 1, non-receptor tyrosine kinase; Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN ( [...] (1149 aa)
        score_image   score_image   0.948
HRAS
v-Ha-ras Harvey rat sarcoma viral oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (189 aa)
        score_image score_image score_image   0.941
CAMK2D
calcium/calmodulin-dependent protein kinase II delta; Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart f [...] (499 aa)
        score_image score_image score_image   0.936
CAMK2A
calcium/calmodulin-dependent protein kinase II alpha; CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity) (489 aa)
        score_image score_image score_image   0.936
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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