| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AP2M1 | CLTC | ENSP00000292807 | ENSP00000269122 | adaptor-related protein complex 2, mu 1 subunit; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a [...] | clathrin, heavy chain (Hc); Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network | 0.979 |
| AP2M1 | EHD2 | ENSP00000292807 | ENSP00000263277 | adaptor-related protein complex 2, mu 1 subunit; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a [...] | EH-domain containing 2; Plays a role in membrane reorganization in response to nucleotide hydrolysis. Binds to liposomes and deforms them into tubules. Plays a role in membrane trafficking between the plasma membrane and endosomes. Important for the internalization of GLUT4. Required for normal fusion of myoblasts to skeletal muscle myotubes. Binds ATP; does not bind GTP (By similarity) | 0.914 |
| CLTC | AP2M1 | ENSP00000269122 | ENSP00000292807 | clathrin, heavy chain (Hc); Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network | adaptor-related protein complex 2, mu 1 subunit; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a [...] | 0.979 |
| CLTC | EHD1 | ENSP00000269122 | ENSP00000320516 | clathrin, heavy chain (Hc); Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network | EH-domain containing 1; Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes | 0.585 |
| CLTC | EHD2 | ENSP00000269122 | ENSP00000263277 | clathrin, heavy chain (Hc); Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network | EH-domain containing 2; Plays a role in membrane reorganization in response to nucleotide hydrolysis. Binds to liposomes and deforms them into tubules. Plays a role in membrane trafficking between the plasma membrane and endosomes. Important for the internalization of GLUT4. Required for normal fusion of myoblasts to skeletal muscle myotubes. Binds ATP; does not bind GTP (By similarity) | 0.820 |
| CLTC | RAB5A | ENSP00000269122 | ENSP00000273047 | clathrin, heavy chain (Hc); Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network | RAB5A, member RAS oncogene family; Required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension | 0.665 |
| CLTC | SLC2A4 | ENSP00000269122 | ENSP00000320935 | clathrin, heavy chain (Hc); Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network | solute carrier family 2 (facilitated glucose transporter), member 4; Insulin-regulated facilitative glucose transporter | 0.912 |
| EHBP1 | EHD1 | ENSP00000263991 | ENSP00000320516 | EH domain binding protein 1 | EH-domain containing 1; Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes | 0.810 |
| EHBP1 | EHD2 | ENSP00000263991 | ENSP00000263277 | EH domain binding protein 1 | EH-domain containing 2; Plays a role in membrane reorganization in response to nucleotide hydrolysis. Binds to liposomes and deforms them into tubules. Plays a role in membrane trafficking between the plasma membrane and endosomes. Important for the internalization of GLUT4. Required for normal fusion of myoblasts to skeletal muscle myotubes. Binds ATP; does not bind GTP (By similarity) | 0.896 |
| EHBP1 | EHD3 | ENSP00000263991 | ENSP00000327116 | EH domain binding protein 1 | EH-domain containing 3; Plays a role in endocytic transport | 0.769 |
| EHD1 | CLTC | ENSP00000320516 | ENSP00000269122 | EH-domain containing 1; Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes | clathrin, heavy chain (Hc); Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network | 0.585 |
| EHD1 | EHBP1 | ENSP00000320516 | ENSP00000263991 | EH-domain containing 1; Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes | EH domain binding protein 1 | 0.810 |
| EHD1 | EHD2 | ENSP00000320516 | ENSP00000263277 | EH-domain containing 1; Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes | EH-domain containing 2; Plays a role in membrane reorganization in response to nucleotide hydrolysis. Binds to liposomes and deforms them into tubules. Plays a role in membrane trafficking between the plasma membrane and endosomes. Important for the internalization of GLUT4. Required for normal fusion of myoblasts to skeletal muscle myotubes. Binds ATP; does not bind GTP (By similarity) | 0.907 |
| EHD1 | EHD3 | ENSP00000320516 | ENSP00000327116 | EH-domain containing 1; Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes | EH-domain containing 3; Plays a role in endocytic transport | 0.956 |
| EHD1 | PACSIN2 | ENSP00000320516 | ENSP00000263246 | EH-domain containing 1; Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes | protein kinase C and casein kinase substrate in neurons 2; Plays a role in the formation of normal, flask-shaped caveolae at the cell membrane. Recruits DNM2 to caveolae, and thereby plays a role in caveola-mediated endocytosis. Plays a role in intracellular vesicle-mediated transport. Binds to membranes via its F-BAR domain and promotes membrane tubulation. Plays a role in the internalization of cell-surface receptors. Is not required for internalization of EGFR after EGF stimulus, but contributes to the internalization of EGFR in the absence of EGF stimulus | 0.593 |
| EHD1 | RAB5A | ENSP00000320516 | ENSP00000273047 | EH-domain containing 1; Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes | RAB5A, member RAS oncogene family; Required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension | 0.923 |
| EHD1 | ZFYVE20 | ENSP00000320516 | ENSP00000253699 | EH-domain containing 1; Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes | zinc finger, FYVE domain containing 20; Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3) | 0.998 |
| EHD2 | AP2M1 | ENSP00000263277 | ENSP00000292807 | EH-domain containing 2; Plays a role in membrane reorganization in response to nucleotide hydrolysis. Binds to liposomes and deforms them into tubules. Plays a role in membrane trafficking between the plasma membrane and endosomes. Important for the internalization of GLUT4. Required for normal fusion of myoblasts to skeletal muscle myotubes. Binds ATP; does not bind GTP (By similarity) | adaptor-related protein complex 2, mu 1 subunit; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a [...] | 0.914 |
| EHD2 | CLTC | ENSP00000263277 | ENSP00000269122 | EH-domain containing 2; Plays a role in membrane reorganization in response to nucleotide hydrolysis. Binds to liposomes and deforms them into tubules. Plays a role in membrane trafficking between the plasma membrane and endosomes. Important for the internalization of GLUT4. Required for normal fusion of myoblasts to skeletal muscle myotubes. Binds ATP; does not bind GTP (By similarity) | clathrin, heavy chain (Hc); Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network | 0.820 |
| EHD2 | EHBP1 | ENSP00000263277 | ENSP00000263991 | EH-domain containing 2; Plays a role in membrane reorganization in response to nucleotide hydrolysis. Binds to liposomes and deforms them into tubules. Plays a role in membrane trafficking between the plasma membrane and endosomes. Important for the internalization of GLUT4. Required for normal fusion of myoblasts to skeletal muscle myotubes. Binds ATP; does not bind GTP (By similarity) | EH domain binding protein 1 | 0.896 |
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