| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ASIC3 | NPS | ENSP00000297512 | ENSP00000381105 | acid-sensing (proton-gated) ion channel 3; Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties | neuropeptide S; Modulates arousal and anxiety. May play an important anorexigenic role. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (By similarity) | 0.507 |
| ASIC3 | P2RX3 | ENSP00000297512 | ENSP00000263314 | acid-sensing (proton-gated) ion channel 3; Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties | purinergic receptor P2X, ligand-gated ion channel, 3; Receptor for ATP that acts as a ligand-gated ion channel | 0.700 |
| ASIC3 | TRPV1 | ENSP00000297512 | ENSP00000382659 | acid-sensing (proton-gated) ion channel 3; Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties | transient receptor potential cation channel, subfamily V, member 1; Receptor-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. May be involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Trigger [...] | 0.756 |
| ASIC3 | VR1 | ENSP00000297512 | ENSP00000459962 | acid-sensing (proton-gated) ion channel 3; Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties | transient receptor potential cation channel subfamily V member 1 ; Receptor-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. May be involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers [...] | 0.754 |
| NPS | ASIC3 | ENSP00000381105 | ENSP00000297512 | neuropeptide S; Modulates arousal and anxiety. May play an important anorexigenic role. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (By similarity) | acid-sensing (proton-gated) ion channel 3; Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties | 0.507 |
| NPS | P2RX3 | ENSP00000381105 | ENSP00000263314 | neuropeptide S; Modulates arousal and anxiety. May play an important anorexigenic role. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (By similarity) | purinergic receptor P2X, ligand-gated ion channel, 3; Receptor for ATP that acts as a ligand-gated ion channel | 0.704 |
| NPS | P2RY1 | ENSP00000381105 | ENSP00000304767 | neuropeptide S; Modulates arousal and anxiety. May play an important anorexigenic role. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (By similarity) | purinergic receptor P2Y, G-protein coupled, 1; Receptor for extracellular adenine nucleotides such as ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation | 0.916 |
| NPS | P2RY2 | ENSP00000381105 | ENSP00000310305 | neuropeptide S; Modulates arousal and anxiety. May play an important anorexigenic role. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (By similarity) | purinergic receptor P2Y, G-protein coupled, 2; Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP | 0.907 |
| NPS | TRPV1 | ENSP00000381105 | ENSP00000382659 | neuropeptide S; Modulates arousal and anxiety. May play an important anorexigenic role. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (By similarity) | transient receptor potential cation channel, subfamily V, member 1; Receptor-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. May be involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Trigger [...] | 0.756 |
| NPS | VR1 | ENSP00000381105 | ENSP00000459962 | neuropeptide S; Modulates arousal and anxiety. May play an important anorexigenic role. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (By similarity) | transient receptor potential cation channel subfamily V member 1 ; Receptor-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. May be involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers [...] | 0.725 |
| P2RX3 | ASIC3 | ENSP00000263314 | ENSP00000297512 | purinergic receptor P2X, ligand-gated ion channel, 3; Receptor for ATP that acts as a ligand-gated ion channel | acid-sensing (proton-gated) ion channel 3; Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties | 0.700 |
| P2RX3 | NPS | ENSP00000263314 | ENSP00000381105 | purinergic receptor P2X, ligand-gated ion channel, 3; Receptor for ATP that acts as a ligand-gated ion channel | neuropeptide S; Modulates arousal and anxiety. May play an important anorexigenic role. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (By similarity) | 0.704 |
| P2RX3 | P2RY1 | ENSP00000263314 | ENSP00000304767 | purinergic receptor P2X, ligand-gated ion channel, 3; Receptor for ATP that acts as a ligand-gated ion channel | purinergic receptor P2Y, G-protein coupled, 1; Receptor for extracellular adenine nucleotides such as ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation | 0.790 |
| P2RX3 | P2RY12 | ENSP00000263314 | ENSP00000307259 | purinergic receptor P2X, ligand-gated ion channel, 3; Receptor for ATP that acts as a ligand-gated ion channel | purinergic receptor P2Y, G-protein coupled, 12; Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Involved in platelet aggregation | 0.741 |
| P2RX3 | P2RY13 | ENSP00000263314 | ENSP00000320376 | purinergic receptor P2X, ligand-gated ion channel, 3; Receptor for ATP that acts as a ligand-gated ion channel | purinergic receptor P2Y, G-protein coupled, 13; Receptor for ADP. Coupled to G(i)-proteins. May play a role in hematopoiesis and the immune system | 0.751 |
| P2RX3 | P2RY14 | ENSP00000263314 | ENSP00000308361 | purinergic receptor P2X, ligand-gated ion channel, 3; Receptor for ATP that acts as a ligand-gated ion channel | purinergic receptor P2Y, G-protein coupled, 14; Receptor for UDP-glucose and other UDP-sugar coupled to G-proteins. Not activated by ATP, ADP, UTP or ATP | 0.715 |
| P2RX3 | P2RY2 | ENSP00000263314 | ENSP00000310305 | purinergic receptor P2X, ligand-gated ion channel, 3; Receptor for ATP that acts as a ligand-gated ion channel | purinergic receptor P2Y, G-protein coupled, 2; Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP | 0.749 |
| P2RX3 | TRPV1 | ENSP00000263314 | ENSP00000382659 | purinergic receptor P2X, ligand-gated ion channel, 3; Receptor for ATP that acts as a ligand-gated ion channel | transient receptor potential cation channel, subfamily V, member 1; Receptor-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. May be involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Trigger [...] | 0.891 |
| P2RX3 | VR1 | ENSP00000263314 | ENSP00000459962 | purinergic receptor P2X, ligand-gated ion channel, 3; Receptor for ATP that acts as a ligand-gated ion channel | transient receptor potential cation channel subfamily V member 1 ; Receptor-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. May be involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers [...] | 0.887 |
| P2RX3 | ZNF77 | ENSP00000263314 | ENSP00000319053 | purinergic receptor P2X, ligand-gated ion channel, 3; Receptor for ATP that acts as a ligand-gated ion channel | zinc finger protein 77; May be involved in transcriptional regulation | 0.814 |
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