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TLK2 TLK2 TLK1 TLK1 HIST1H3F HIST1H3F ASF1B ASF1B HIST1H3C HIST1H3C HIST1H3E HIST1H3E CHAF1B CHAF1B MCM6 MCM6 H3F3A H3F3A CHAF1A CHAF1A HIST1H3J HIST1H3J
"ASF1B" - ASF1 anti-silencing function 1 homolog B (S. cerevisiae) in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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Known Interactions
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Predicted Interactions
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gene co-occurrence
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protein homology
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ASF1BASF1 anti-silencing function 1 homolog B (S. cerevisiae); Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly. Does not participate in replication-independent nucleosome deposition which is mediated by ASF1A and HIRA. Required for spermatogenesis (202 aa)    
Predicted Functional Partners:
TLK1
tousled-like kinase 1; Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S- phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at ’Ser-10’ (766 aa)
      score_image score_image   score_image   0.999
H3F3A
H3 histone, family 3A; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a centra [...] (136 aa)
      score_image score_image   score_image   0.996
CHAF1B
chromatin assembly factor 1, subunit B (p60); Complex that is thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer (559 aa)
      score_image score_image   score_image   0.996
TLK2
tousled-like kinase 2; Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A AND ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly. Negative regulator of amino acid starvation-induced autophagy (750 aa)
      score_image score_image   score_image   0.994
HIST1H3C
histone cluster 1, H3c (136 aa)
      score_image score_image   score_image   0.992
HIST1H3E
histone cluster 1, H3e (136 aa)
      score_image score_image   score_image   0.991
HIST1H3J
histone cluster 1, H3j (136 aa)
      score_image score_image   score_image   0.991
MCM6
minichromosome maintenance complex component 6; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for ’once per cell cycle’ DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute dif [...] (821 aa)
      score_image score_image   score_image   0.977
HIST1H3F
histone cluster 1, H3f (136 aa)
      score_image score_image   score_image   0.974
CHAF1A
chromatin assembly factor 1, subunit A (p150); Core component of the CAF-1 complex, a complex thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. CHAF1A binds to histones H3 and H4. It may play a role in heterochromatin maintenance in proliferating cells by bringi [...] (956 aa)
      score_image score_image   score_image   0.974
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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