WDR11 protein (Homo sapiens) - STRING network view

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WDR11

WD repeat domain 11 (1224 aa)

Predicted Functional Partners:

TNFRSF25

0.708

HS6ST1

0.659

FOXRED1

0.648

UBC

0.620

TAC3

0.584

TOR1A

0.583

HLA-DQB1

0.582

HLA-DRB1

0.581

MAGEA3

0.567

TACR3

0.560

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FOXRED1	HS6ST1	ENSP00000263578	ENSP00000259241	FAD-dependent oxidoreductase domain containing 1	heparan sulfate 6-O-sulfotransferase 1; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3’-phosphoadenosine 5’-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate	0.700
FOXRED1	TAC3	ENSP00000263578	ENSP00000300108	FAD-dependent oxidoreductase domain containing 1	tachykinin 3; Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles (By similarity). Is a critical central regulator of gonadal function	0.570
FOXRED1	TACR3	ENSP00000263578	ENSP00000303325	FAD-dependent oxidoreductase domain containing 1	tachykinin receptor 3; This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is- neuromedin-K > substance K > substance P	0.562
FOXRED1	UBC	ENSP00000263578	ENSP00000344818	FAD-dependent oxidoreductase domain containing 1	ubiquitin C	0.721
FOXRED1	WDR11	ENSP00000263578	ENSP00000263461	FAD-dependent oxidoreductase domain containing 1	WD repeat domain 11	0.648
HLA-DQB1	TNFRSF25	ENSP00000382034	ENSP00000367013	major histocompatibility complex, class II, DQ beta 1	tumor necrosis factor receptor superfamily, member 25	0.729
HLA-DQB1	TOR1A	ENSP00000382034	ENSP00000345719	major histocompatibility complex, class II, DQ beta 1	torsin family 1, member A (torsin A); May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins. In the nucleus, displaces the nuclear membrane proteins SUN2, SYNE2 and SYNE3, leaving nuclear pores and SUN1 unchanged	0.824
HLA-DQB1	UBC	ENSP00000382034	ENSP00000344818	major histocompatibility complex, class II, DQ beta 1	ubiquitin C	0.494
HLA-DQB1	WDR11	ENSP00000382034	ENSP00000263461	major histocompatibility complex, class II, DQ beta 1	WD repeat domain 11	0.582
HLA-DRB1	TNFRSF25	ENSP00000353099	ENSP00000367013	major histocompatibility complex, class II, DR beta 1	tumor necrosis factor receptor superfamily, member 25	0.407
HLA-DRB1	WDR11	ENSP00000353099	ENSP00000263461	major histocompatibility complex, class II, DR beta 1	WD repeat domain 11	0.581
HS6ST1	FOXRED1	ENSP00000259241	ENSP00000263578	heparan sulfate 6-O-sulfotransferase 1; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3’-phosphoadenosine 5’-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate	FAD-dependent oxidoreductase domain containing 1	0.700
HS6ST1	TAC3	ENSP00000259241	ENSP00000300108	heparan sulfate 6-O-sulfotransferase 1; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3’-phosphoadenosine 5’-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate	tachykinin 3; Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles (By similarity). Is a critical central regulator of gonadal function	0.635
HS6ST1	TACR3	ENSP00000259241	ENSP00000303325	heparan sulfate 6-O-sulfotransferase 1; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3’-phosphoadenosine 5’-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate	tachykinin receptor 3; This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is- neuromedin-K > substance K > substance P	0.623
HS6ST1	WDR11	ENSP00000259241	ENSP00000263461	heparan sulfate 6-O-sulfotransferase 1; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3’-phosphoadenosine 5’-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate	WD repeat domain 11	0.659
MAGEA3	UBC	ENSP00000359301	ENSP00000344818	melanoma antigen family A, 3; Proposed to enhance ubiquitin ligase activity of RING- type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3-substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes	ubiquitin C	0.633
MAGEA3	WDR11	ENSP00000359301	ENSP00000263461	melanoma antigen family A, 3; Proposed to enhance ubiquitin ligase activity of RING- type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3-substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes	WD repeat domain 11	0.567
TAC3	FOXRED1	ENSP00000300108	ENSP00000263578	tachykinin 3; Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles (By similarity). Is a critical central regulator of gonadal function	FAD-dependent oxidoreductase domain containing 1	0.570
TAC3	HS6ST1	ENSP00000300108	ENSP00000259241	tachykinin 3; Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles (By similarity). Is a critical central regulator of gonadal function	heparan sulfate 6-O-sulfotransferase 1; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3’-phosphoadenosine 5’-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate	0.635
TAC3	TACR3	ENSP00000300108	ENSP00000303325	tachykinin 3; Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles (By similarity). Is a critical central regulator of gonadal function	tachykinin receptor 3; This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is- neuromedin-K > substance K > substance P	0.999

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