Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | KIAA1377 | KIAA1377 (1117 aa) | ||||||||||||
Predicted Functional Partners:
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 | LAMTOR5 | late endosomal/lysosomal adaptor, MAPK and MTOR activator 5; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interfe [...] (173 aa) |
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0.640 | ||||||||||
 | DISC1 | disrupted in schizophrenia 1 (755 aa) |
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0.612 | |||||||||
 | DGCR6 | DiGeorge syndrome critical region gene 6; May play a role in neural crest cell migration into the third and fourth pharyngeal pouches (220 aa) |
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0.572 | ||||||||||
 | C5orf42 | chromosome 5 open reading frame 42 (3197 aa) |
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0.566 | ||||||||||
 | C16orf89 | chromosome 16 open reading frame 89 (402 aa) |
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0.508 | ||||||||||
 | C11orf70 | chromosome 11 open reading frame 70 (267 aa) |
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0.504 | ||||||||||
 | ZNF613 | zinc finger protein 613; May be involved in transcriptional regulation (617 aa) |
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0.502 | ||||||||||
 | GLT25D2 | glycosyltransferase 25 domain containing 2; Has a beta-galactosyltransferase activity; transfers beta-galactose to hydroxylysine residues on collagen (626 aa) |
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0.481 | ||||||||||
 | ADCYAP1R1 | adenylate cyclase activating polypeptide 1 (pituitary) receptor type I; This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract (496 aa) |
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0.455 | ||||||||||
 | CEP128 | centrosomal protein 128kDa (1094 aa) |
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0.418 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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