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VAMP7 VAMP7 PPP3R2 PPP3R2 CHP1 CHP1 TESC TESC CIB1 CIB1 ATP2B3 ATP2B3 KRT74 KRT74 PPP3R1 PPP3R1 CHP2 CHP2 CIB4 CIB4 KRT71 KRT71
"ATP2B3" - ATPase, Ca++ transporting, plasma membrane 3 in Homo sapiens
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protein of unknown 3D structure
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Predicted Interactions
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ATP2B3ATPase, Ca++ transporting, plasma membrane 3 (1220 aa)    
Predicted Functional Partners:
VAMP7
vesicle-associated membrane protein 7; Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocy [...] (260 aa)
        score_image   score_image   0.793
KRT74
keratin 74; Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable) (529 aa)
            score_image   0.739
KRT71
keratin 71; Plays a central role in hair formation. Essential component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable) (523 aa)
            score_image   0.739
PPP3R2
protein phosphatase 3, regulatory subunit B, beta; Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity (By similarity) (173 aa)
        score_image   score_image   0.731
PPP3R1
protein phosphatase 3, regulatory subunit B, alpha; Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity (170 aa)
        score_image   score_image   0.731
CHP1
calcineurin-like EF hand protein 1; Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exc [...] (195 aa)
        score_image   score_image   0.686
TESC
tescalcin; Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Promotes the maturation, transport, cell surface stability and exchange activity of SLC9A1/NHE1 at the plasma membrane. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calc [...] (214 aa)
        score_image   score_image   0.686
CIB1
calcium and integrin binding 1 (calmyrin); May convert the inactive conformation of integrin alpha- IIb/beta3 to an active form through binding to the integrin cytoplasmic domain. Induces cell migration and spreading mediated through integrin (possibly via focal adhesion complexes). Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. May play a role in regulation of apoptosis. Interacts with and up-regulates PTK2/FAK1 activity. Down regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling. Participates in endomitotic cell cycle [...] (191 aa)
        score_image   score_image   0.686
CHP2
calcineurin-like EF hand protein 2; Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation- induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to t [...] (196 aa)
        score_image   score_image   0.686
CIB4
calcium and integrin binding family member 4 (185 aa)
        score_image   score_image   0.686
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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