node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATP2B3 | CHP1 | ENSP00000263519 | ENSP00000335632 | ATPase, Ca++ transporting, plasma membrane 3 | calcineurin-like EF hand protein 1; Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exc [...] | 0.686 |
ATP2B3 | CHP2 | ENSP00000263519 | ENSP00000300113 | ATPase, Ca++ transporting, plasma membrane 3 | calcineurin-like EF hand protein 2; Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation- induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to t [...] | 0.686 |
ATP2B3 | CIB1 | ENSP00000263519 | ENSP00000333873 | ATPase, Ca++ transporting, plasma membrane 3 | calcium and integrin binding 1 (calmyrin); May convert the inactive conformation of integrin alpha- IIb/beta3 to an active form through binding to the integrin cytoplasmic domain. Induces cell migration and spreading mediated through integrin (possibly via focal adhesion complexes). Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. May play a role in regulation of apoptosis. Interacts with and up-regulates PTK2/FAK1 activity. Down regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling. Participates in endomitotic cell cycle [...] | 0.686 |
ATP2B3 | CIB4 | ENSP00000263519 | ENSP00000288861 | ATPase, Ca++ transporting, plasma membrane 3 | calcium and integrin binding family member 4 | 0.686 |
ATP2B3 | KRT71 | ENSP00000263519 | ENSP00000267119 | ATPase, Ca++ transporting, plasma membrane 3 | keratin 71; Plays a central role in hair formation. Essential component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable) | 0.739 |
ATP2B3 | KRT74 | ENSP00000263519 | ENSP00000307240 | ATPase, Ca++ transporting, plasma membrane 3 | keratin 74; Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable) | 0.739 |
ATP2B3 | PPP3R1 | ENSP00000263519 | ENSP00000234310 | ATPase, Ca++ transporting, plasma membrane 3 | protein phosphatase 3, regulatory subunit B, alpha; Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity | 0.731 |
ATP2B3 | PPP3R2 | ENSP00000263519 | ENSP00000363939 | ATPase, Ca++ transporting, plasma membrane 3 | protein phosphatase 3, regulatory subunit B, beta; Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity (By similarity) | 0.731 |
ATP2B3 | TESC | ENSP00000263519 | ENSP00000334785 | ATPase, Ca++ transporting, plasma membrane 3 | tescalcin; Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Promotes the maturation, transport, cell surface stability and exchange activity of SLC9A1/NHE1 at the plasma membrane. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calc [...] | 0.686 |
ATP2B3 | VAMP7 | ENSP00000263519 | ENSP00000262640 | ATPase, Ca++ transporting, plasma membrane 3 | vesicle-associated membrane protein 7; Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocy [...] | 0.793 |
CHP1 | ATP2B3 | ENSP00000335632 | ENSP00000263519 | calcineurin-like EF hand protein 1; Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exc [...] | ATPase, Ca++ transporting, plasma membrane 3 | 0.686 |
CHP2 | ATP2B3 | ENSP00000300113 | ENSP00000263519 | calcineurin-like EF hand protein 2; Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation- induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to t [...] | ATPase, Ca++ transporting, plasma membrane 3 | 0.686 |
CIB1 | ATP2B3 | ENSP00000333873 | ENSP00000263519 | calcium and integrin binding 1 (calmyrin); May convert the inactive conformation of integrin alpha- IIb/beta3 to an active form through binding to the integrin cytoplasmic domain. Induces cell migration and spreading mediated through integrin (possibly via focal adhesion complexes). Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. May play a role in regulation of apoptosis. Interacts with and up-regulates PTK2/FAK1 activity. Down regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling. Participates in endomitotic cell cycle [...] | ATPase, Ca++ transporting, plasma membrane 3 | 0.686 |
CIB4 | ATP2B3 | ENSP00000288861 | ENSP00000263519 | calcium and integrin binding family member 4 | ATPase, Ca++ transporting, plasma membrane 3 | 0.686 |
KRT71 | ATP2B3 | ENSP00000267119 | ENSP00000263519 | keratin 71; Plays a central role in hair formation. Essential component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable) | ATPase, Ca++ transporting, plasma membrane 3 | 0.739 |
KRT74 | ATP2B3 | ENSP00000307240 | ENSP00000263519 | keratin 74; Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable) | ATPase, Ca++ transporting, plasma membrane 3 | 0.739 |
PPP3R1 | ATP2B3 | ENSP00000234310 | ENSP00000263519 | protein phosphatase 3, regulatory subunit B, alpha; Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity | ATPase, Ca++ transporting, plasma membrane 3 | 0.731 |
PPP3R2 | ATP2B3 | ENSP00000363939 | ENSP00000263519 | protein phosphatase 3, regulatory subunit B, beta; Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity (By similarity) | ATPase, Ca++ transporting, plasma membrane 3 | 0.731 |
TESC | ATP2B3 | ENSP00000334785 | ENSP00000263519 | tescalcin; Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Promotes the maturation, transport, cell surface stability and exchange activity of SLC9A1/NHE1 at the plasma membrane. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calc [...] | ATPase, Ca++ transporting, plasma membrane 3 | 0.686 |
VAMP7 | ATP2B3 | ENSP00000262640 | ENSP00000263519 | vesicle-associated membrane protein 7; Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocy [...] | ATPase, Ca++ transporting, plasma membrane 3 | 0.793 |