| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DDX25 | DRAP1 | ENSP00000263576 | ENSP00000307850 | DEAD (Asp-Glu-Ala-Asp) box helicase 25; ATP-dependent RNA helicase. Required for mRNA export and translation regulation during spermatid development (By similarity) | DR1-associated protein 1 (negative cofactor 2 alpha); The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own | 0.727 |
| DDX25 | GLE1 | ENSP00000263576 | ENSP00000308622 | DEAD (Asp-Glu-Ala-Asp) box helicase 25; ATP-dependent RNA helicase. Required for mRNA export and translation regulation during spermatid development (By similarity) | GLE1 RNA export mediator homolog (yeast); Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC) | 0.932 |
| DDX25 | HYLS1 | ENSP00000263576 | ENSP00000348815 | DEAD (Asp-Glu-Ala-Asp) box helicase 25; ATP-dependent RNA helicase. Required for mRNA export and translation regulation during spermatid development (By similarity) | hydrolethalus syndrome 1 | 0.881 |
| DDX25 | MCM3AP | ENSP00000263576 | ENSP00000291688 | DEAD (Asp-Glu-Ala-Asp) box helicase 25; ATP-dependent RNA helicase. Required for mRNA export and translation regulation during spermatid development (By similarity) | minichromosome maintenance complex component 3 associated protein; May be involved in the nuclear localization pathway of MCM3 | 0.741 |
| DDX25 | NXF2 | ENSP00000263576 | ENSP00000331471 | DEAD (Asp-Glu-Ala-Asp) box helicase 25; ATP-dependent RNA helicase. Required for mRNA export and translation regulation during spermatid development (By similarity) | nuclear RNA export factor 2 | 0.687 |
| DDX25 | NXF2B | ENSP00000263576 | ENSP00000361835 | DEAD (Asp-Glu-Ala-Asp) box helicase 25; ATP-dependent RNA helicase. Required for mRNA export and translation regulation during spermatid development (By similarity) | nuclear RNA export factor 2B; Involved in the export of mRNA from the nucleus to the cytoplasm | 0.698 |
| DDX25 | PKNOX2 | ENSP00000263576 | ENSP00000298282 | DEAD (Asp-Glu-Ala-Asp) box helicase 25; ATP-dependent RNA helicase. Required for mRNA export and translation regulation during spermatid development (By similarity) | PBX/knotted 1 homeobox 2 | 0.861 |
| DDX25 | PUS3 | ENSP00000263576 | ENSP00000227474 | DEAD (Asp-Glu-Ala-Asp) box helicase 25; ATP-dependent RNA helicase. Required for mRNA export and translation regulation during spermatid development (By similarity) | pseudouridylate synthase 3; Formation of pseudouridine at position 39 in the anticodon stem and loop of transfer RNAs (By similarity) | 0.692 |
| DDX25 | XPO1 | ENSP00000263576 | ENSP00000384863 | DEAD (Asp-Glu-Ala-Asp) box helicase 25; ATP-dependent RNA helicase. Required for mRNA export and translation regulation during spermatid development (By similarity) | exportin 1 (CRM1 homolog, yeast); Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) c [...] | 0.812 |
| DDX25 | ZC3H14 | ENSP00000263576 | ENSP00000251038 | DEAD (Asp-Glu-Ala-Asp) box helicase 25; ATP-dependent RNA helicase. Required for mRNA export and translation regulation during spermatid development (By similarity) | zinc finger CCCH-type containing 14 | 0.742 |
| DRAP1 | DDX25 | ENSP00000307850 | ENSP00000263576 | DR1-associated protein 1 (negative cofactor 2 alpha); The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own | DEAD (Asp-Glu-Ala-Asp) box helicase 25; ATP-dependent RNA helicase. Required for mRNA export and translation regulation during spermatid development (By similarity) | 0.727 |
| GLE1 | DDX25 | ENSP00000308622 | ENSP00000263576 | GLE1 RNA export mediator homolog (yeast); Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC) | DEAD (Asp-Glu-Ala-Asp) box helicase 25; ATP-dependent RNA helicase. Required for mRNA export and translation regulation during spermatid development (By similarity) | 0.932 |
| GLE1 | MCM3AP | ENSP00000308622 | ENSP00000291688 | GLE1 RNA export mediator homolog (yeast); Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC) | minichromosome maintenance complex component 3 associated protein; May be involved in the nuclear localization pathway of MCM3 | 0.713 |
| GLE1 | NXF2 | ENSP00000308622 | ENSP00000331471 | GLE1 RNA export mediator homolog (yeast); Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC) | nuclear RNA export factor 2 | 0.653 |
| GLE1 | NXF2B | ENSP00000308622 | ENSP00000361835 | GLE1 RNA export mediator homolog (yeast); Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC) | nuclear RNA export factor 2B; Involved in the export of mRNA from the nucleus to the cytoplasm | 0.655 |
| GLE1 | XPO1 | ENSP00000308622 | ENSP00000384863 | GLE1 RNA export mediator homolog (yeast); Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC) | exportin 1 (CRM1 homolog, yeast); Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) c [...] | 0.697 |
| GLE1 | ZC3H14 | ENSP00000308622 | ENSP00000251038 | GLE1 RNA export mediator homolog (yeast); Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC) | zinc finger CCCH-type containing 14 | 0.460 |
| HYLS1 | DDX25 | ENSP00000348815 | ENSP00000263576 | hydrolethalus syndrome 1 | DEAD (Asp-Glu-Ala-Asp) box helicase 25; ATP-dependent RNA helicase. Required for mRNA export and translation regulation during spermatid development (By similarity) | 0.881 |
| HYLS1 | PKNOX2 | ENSP00000348815 | ENSP00000298282 | hydrolethalus syndrome 1 | PBX/knotted 1 homeobox 2 | 0.861 |
| HYLS1 | PUS3 | ENSP00000348815 | ENSP00000227474 | hydrolethalus syndrome 1 | pseudouridylate synthase 3; Formation of pseudouridine at position 39 in the anticodon stem and loop of transfer RNAs (By similarity) | 0.639 |
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