node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ASB4 | ASCL2 | ENSP00000321388 | ENSP00000332293 | ankyrin repeat and SOCS box containing 4; Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes differentiation and maturation of the vascular lineage by an oxygen-dependent mechanism (By similarity) | achaete-scute complex homolog 2 (Drosophila); AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system | 0.422 |
ASB4 | OSBPL5 | ENSP00000321388 | ENSP00000263650 | ankyrin repeat and SOCS box containing 4; Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes differentiation and maturation of the vascular lineage by an oxygen-dependent mechanism (By similarity) | oxysterol binding protein-like 5; May cooperate with NPC1 to mediate the exit of cholesterol from endosomes/lysosomes | 0.591 |
ASCL2 | ASB4 | ENSP00000332293 | ENSP00000321388 | achaete-scute complex homolog 2 (Drosophila); AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system | ankyrin repeat and SOCS box containing 4; Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes differentiation and maturation of the vascular lineage by an oxygen-dependent mechanism (By similarity) | 0.422 |
ASCL2 | MRPL23 | ENSP00000332293 | ENSP00000370930 | achaete-scute complex homolog 2 (Drosophila); AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system | mitochondrial ribosomal protein L23 | 0.491 |
ASCL2 | NAP1L4 | ENSP00000332293 | ENSP00000369915 | achaete-scute complex homolog 2 (Drosophila); AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system | nucleosome assembly protein 1-like 4 | 0.502 |
ASCL2 | OSBPL5 | ENSP00000332293 | ENSP00000263650 | achaete-scute complex homolog 2 (Drosophila); AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system | oxysterol binding protein-like 5; May cooperate with NPC1 to mediate the exit of cholesterol from endosomes/lysosomes | 0.624 |
ASCL2 | SLC22A18 | ENSP00000332293 | ENSP00000307859 | achaete-scute complex homolog 2 (Drosophila); AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system | solute carrier family 22, member 18; May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney | 0.662 |
ATP10A | NAP1L4 | ENSP00000349325 | ENSP00000369915 | ATPase, class V, type 10A | nucleosome assembly protein 1-like 4 | 0.505 |
ATP10A | OSBPL5 | ENSP00000349325 | ENSP00000263650 | ATPase, class V, type 10A | oxysterol binding protein-like 5; May cooperate with NPC1 to mediate the exit of cholesterol from endosomes/lysosomes | 0.628 |
MRPL23 | ASCL2 | ENSP00000370930 | ENSP00000332293 | mitochondrial ribosomal protein L23 | achaete-scute complex homolog 2 (Drosophila); AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system | 0.491 |
MRPL23 | NAP1L4 | ENSP00000370930 | ENSP00000369915 | mitochondrial ribosomal protein L23 | nucleosome assembly protein 1-like 4 | 0.681 |
MRPL23 | OSBPL5 | ENSP00000370930 | ENSP00000263650 | mitochondrial ribosomal protein L23 | oxysterol binding protein-like 5; May cooperate with NPC1 to mediate the exit of cholesterol from endosomes/lysosomes | 0.655 |
NAP1L4 | ASCL2 | ENSP00000369915 | ENSP00000332293 | nucleosome assembly protein 1-like 4 | achaete-scute complex homolog 2 (Drosophila); AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system | 0.502 |
NAP1L4 | ATP10A | ENSP00000369915 | ENSP00000349325 | nucleosome assembly protein 1-like 4 | ATPase, class V, type 10A | 0.505 |
NAP1L4 | MRPL23 | ENSP00000369915 | ENSP00000370930 | nucleosome assembly protein 1-like 4 | mitochondrial ribosomal protein L23 | 0.681 |
NAP1L4 | OSBPL5 | ENSP00000369915 | ENSP00000263650 | nucleosome assembly protein 1-like 4 | oxysterol binding protein-like 5; May cooperate with NPC1 to mediate the exit of cholesterol from endosomes/lysosomes | 0.650 |
NAP1L4 | SLC22A18 | ENSP00000369915 | ENSP00000307859 | nucleosome assembly protein 1-like 4 | solute carrier family 22, member 18; May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney | 0.435 |
NAP1L4 | UBC | ENSP00000369915 | ENSP00000344818 | nucleosome assembly protein 1-like 4 | ubiquitin C | 0.907 |
NPC1 | OSBPL5 | ENSP00000269228 | ENSP00000263650 | Niemann-Pick disease, type C1; Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular ’tag team duo’ (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding pock [...] | oxysterol binding protein-like 5; May cooperate with NPC1 to mediate the exit of cholesterol from endosomes/lysosomes | 0.939 |
NPC1 | UBC | ENSP00000269228 | ENSP00000344818 | Niemann-Pick disease, type C1; Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular ’tag team duo’ (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding pock [...] | ubiquitin C | 0.943 |