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MRPL23 MRPL23 ATP10A ATP10A NAP1L4 NAP1L4 ASCL2 ASCL2 SLC22A18 SLC22A18 ASB4 ASB4 OSBPL5 OSBPL5 UBC UBC VPS4B VPS4B NPC1 NPC1 VPS4A VPS4A
"OSBPL5" - oxysterol binding protein-like 5 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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experimentally determined
Predicted Interactions
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fusion edge
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gene co-occurrence
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protein homology
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Score
OSBPL5oxysterol binding protein-like 5; May cooperate with NPC1 to mediate the exit of cholesterol from endosomes/lysosomes (879 aa)    
Predicted Functional Partners:
NPC1
Niemann-Pick disease, type C1; Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular ’tag team duo’ (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding pock [...] (1278 aa)
        score_image   score_image   0.939
UBC
ubiquitin C (685 aa)
        score_image       0.746
VPS4A
vacuolar protein sorting 4 homolog A (S. cerevisiae); Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growt [...] (437 aa)
        score_image   score_image   0.706
VPS4B
vacuolar protein sorting 4 homolog B (S. cerevisiae); Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growt [...] (444 aa)
        score_image   score_image   0.691
MRPL23
mitochondrial ribosomal protein L23 (153 aa)
            score_image   0.655
NAP1L4
nucleosome assembly protein 1-like 4 (375 aa)
            score_image   0.650
ATP10A
ATPase, class V, type 10A (1499 aa)
        score_image   score_image   0.628
ASCL2
achaete-scute complex homolog 2 (Drosophila); AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system (193 aa)
            score_image   0.624
SLC22A18
solute carrier family 22, member 18; May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney (424 aa)
            score_image   0.595
ASB4
ankyrin repeat and SOCS box containing 4; Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes differentiation and maturation of the vascular lineage by an oxygen-dependent mechanism (By similarity) (426 aa)
        score_image   score_image   0.591
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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