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STRINGSTRING
WDR75 WDR75 IMP3 IMP3 UTP15 UTP15 PWP2 PWP2 DIMT1 DIMT1 WDR3 WDR3 PNO1 PNO1 BYSL BYSL TSR1 TSR1 NOB1 NOB1 RIOK2 RIOK2
"PNO1" - partner of NOB1 homolog (S. cerevisiae) in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PNO1partner of NOB1 homolog (S. cerevisiae) (252 aa)    
Predicted Functional Partners:
WDR3
WD repeat domain 3 (943 aa)
      score_image score_image   score_image   0.999
BYSL
bystin-like; Required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits. May be required for trophinin-dependent regulation of cell adhesion during implantation of human embryos (437 aa)
      score_image score_image   score_image   0.999
NOB1
NIN1/RPN12 binding protein 1 homolog (S. cerevisiae); May play a role in mRNA degradation (412 aa)
      score_image score_image   score_image   0.997
TSR1
TSR1, 20S rRNA accumulation, homolog (S. cerevisiae); Required during maturation of the 40S ribosomal subunit in the nucleolus (By similarity) (804 aa)
      score_image score_image   score_image   0.995
RIOK2
RIO kinase 2 (yeast) (552 aa)
      score_image score_image   score_image   0.994
DIMT1
DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae); Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3’-end of 18S rRNA in the 40S particle (By similarity) (313 aa)
      score_image score_image   score_image   0.990
WDR75
WD repeat domain 75 (830 aa)
      score_image score_image   score_image   0.989
UTP15
UTP15, U3 small nucleolar ribonucleoprotein, homolog (S. cerevisiae); Involved in nucleolar processing of pre-18S ribosomal RNA (By similarity) (518 aa)
      score_image score_image   score_image   0.986
PWP2
PWP2 periodic tryptophan protein homolog (yeast) (919 aa)
      score_image score_image   score_image   0.985
IMP3
IMP3, U3 small nucleolar ribonucleoprotein, homolog (yeast); Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing (184 aa)
      score_image score_image   score_image   0.984
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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