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BMP7 BMP7 GDF5 GDF5 BMP5 BMP5 XRRA1 XRRA1 BMP2 BMP2 BMP4 BMP4 CHRDL2 CHRDL2 SPCS2 SPCS2 TWSG1 TWSG1 BMP6 BMP6 ENPEP ENPEP
"CHRDL2" - chordin-like 2 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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experimentally determined
Predicted Interactions
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fusion edge
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cooccurrence edge
gene co-occurrence
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coexpression edge
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protein homology
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CHRDL2chordin-like 2; May inhibit BMPs activity by blocking their interaction with their receptors. Has a negative regulator effect on the cartilage formation/regeneration from immature mesenchymal cells, by preventing or reducing the rate of matrix accumulation (By similarity). Implicated in tumor angiogenesis. May play a role during myoblast and osteoblast differentiation, and maturation (451 aa)    
Predicted Functional Partners:
BMP2
bone morphogenetic protein 2; Induces cartilage and bone formation (396 aa)
         score_image   score_image   0.939
BMP5
bone morphogenetic protein 5; Induces cartilage and bone formation (454 aa)
         score_image   score_image   0.802
BMP6
bone morphogenetic protein 6; Induces cartilage and bone formation (513 aa)
         score_image   score_image   0.747
GDF5
growth differentiation factor 5; Could be involved in bone and cartilage formation. Chondrogenic signaling is mediated by the high-affinity receptor BMPR1B (501 aa)
         score_image   score_image   0.746
TWSG1
twisted gastrulation homolog 1 (Drosophila); May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development (By similarity) (223 aa)
             score_image   0.745
BMP7
bone morphogenetic protein 7; Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis (431 aa)
         score_image   score_image   0.716
XRRA1
X-ray radiation resistance associated 1; May be involved in the response of cells to X-ray radiation (792 aa)
             score_image   0.696
BMP4
bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) (408 aa)
         score_image   score_image   0.667
ENPEP
glutamyl aminopeptidase (aminopeptidase A); Appears to have a role in the catabolic pathway of the renin-angiotensin system. Probably plays a role in regulating growth and differentiation of early B-lineage cells (957 aa)
             score_image   0.661
SPCS2
signal peptidase complex subunit 2 homolog (S. cerevisiae); Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity) (226 aa)
             score_image   0.642
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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