| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CCS | TFCP2L1 | ENSP00000436318 | ENSP00000263707 | copper chaperone for superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) | transcription factor CP2-like 1; Transcriptional suppressor. May suppress UBP1-mediated transcriptional activation. Required for normal duct development in the salivary gland and kidney (By similarity). Modulates the placental expression of CYP11A1 | 0.485 |
| CCS | UBP1 | ENSP00000436318 | ENSP00000283628 | copper chaperone for superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) | upstream binding protein 1 (LBP-1a); Functions as a transcriptional activator in a promoter context-dependent manner. Modulates the placental expression of CYP11A1. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2 (By similarity). Involved in regulation of the alpha-globin gene in erythroid cells. Binds strongly to sequences around the HIV-1 initiation site and weakly over the TATA-box. Represses HIV-1 transcription by inhibiting the binding of TFIID to the TATA-box | 0.485 |
| CYP11A1 | TFCP2L1 | ENSP00000268053 | ENSP00000263707 | cytochrome P450, family 11, subfamily A, polypeptide 1; Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone | transcription factor CP2-like 1; Transcriptional suppressor. May suppress UBP1-mediated transcriptional activation. Required for normal duct development in the salivary gland and kidney (By similarity). Modulates the placental expression of CYP11A1 | 0.948 |
| CYP11A1 | TRERF1 | ENSP00000268053 | ENSP00000362013 | cytochrome P450, family 11, subfamily A, polypeptide 1; Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone | transcriptional regulating factor 1; Activates transcription of CYP11A1. Interaction with CREBBP and EP300 results in a synergistic transcriptional activation of CYP11A1 | 0.892 |
| CYP11A1 | UBP1 | ENSP00000268053 | ENSP00000283628 | cytochrome P450, family 11, subfamily A, polypeptide 1; Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone | upstream binding protein 1 (LBP-1a); Functions as a transcriptional activator in a promoter context-dependent manner. Modulates the placental expression of CYP11A1. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2 (By similarity). Involved in regulation of the alpha-globin gene in erythroid cells. Binds strongly to sequences around the HIV-1 initiation site and weakly over the TATA-box. Represses HIV-1 transcription by inhibiting the binding of TFIID to the TATA-box | 0.918 |
| ESRRB | ESRRG | ENSP00000370270 | ENSP00000386171 | estrogen-related receptor beta; Nuclear receptor, may regulate ESR1 transcriptional activity | estrogen-related receptor gamma | 0.901 |
| ESRRB | NANOG | ENSP00000370270 | ENSP00000229307 | estrogen-related receptor beta; Nuclear receptor, may regulate ESR1 transcriptional activity | Nanog homeobox; Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5’-TAAT[GT][GT]-3’ or 5 [...] | 0.983 |
| ESRRB | NANOGP1 | ENSP00000370270 | ENSP00000432545 | estrogen-related receptor beta; Nuclear receptor, may regulate ESR1 transcriptional activity | Nanog homeobox pseudogene 1; Probable transcriptional regulator | 0.736 |
| ESRRB | TFCP2L1 | ENSP00000370270 | ENSP00000263707 | estrogen-related receptor beta; Nuclear receptor, may regulate ESR1 transcriptional activity | transcription factor CP2-like 1; Transcriptional suppressor. May suppress UBP1-mediated transcriptional activation. Required for normal duct development in the salivary gland and kidney (By similarity). Modulates the placental expression of CYP11A1 | 0.837 |
| ESRRB | UBP1 | ENSP00000370270 | ENSP00000283628 | estrogen-related receptor beta; Nuclear receptor, may regulate ESR1 transcriptional activity | upstream binding protein 1 (LBP-1a); Functions as a transcriptional activator in a promoter context-dependent manner. Modulates the placental expression of CYP11A1. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2 (By similarity). Involved in regulation of the alpha-globin gene in erythroid cells. Binds strongly to sequences around the HIV-1 initiation site and weakly over the TATA-box. Represses HIV-1 transcription by inhibiting the binding of TFIID to the TATA-box | 0.587 |
| ESRRG | ESRRB | ENSP00000386171 | ENSP00000370270 | estrogen-related receptor gamma | estrogen-related receptor beta; Nuclear receptor, may regulate ESR1 transcriptional activity | 0.901 |
| ESRRG | NANOG | ENSP00000386171 | ENSP00000229307 | estrogen-related receptor gamma | Nanog homeobox; Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5’-TAAT[GT][GT]-3’ or 5 [...] | 0.527 |
| ESRRG | NANOGP1 | ENSP00000386171 | ENSP00000432545 | estrogen-related receptor gamma | Nanog homeobox pseudogene 1; Probable transcriptional regulator | 0.495 |
| ESRRG | TFCP2L1 | ENSP00000386171 | ENSP00000263707 | estrogen-related receptor gamma | transcription factor CP2-like 1; Transcriptional suppressor. May suppress UBP1-mediated transcriptional activation. Required for normal duct development in the salivary gland and kidney (By similarity). Modulates the placental expression of CYP11A1 | 0.587 |
| ESRRG | UBP1 | ENSP00000386171 | ENSP00000283628 | estrogen-related receptor gamma | upstream binding protein 1 (LBP-1a); Functions as a transcriptional activator in a promoter context-dependent manner. Modulates the placental expression of CYP11A1. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2 (By similarity). Involved in regulation of the alpha-globin gene in erythroid cells. Binds strongly to sequences around the HIV-1 initiation site and weakly over the TATA-box. Represses HIV-1 transcription by inhibiting the binding of TFIID to the TATA-box | 0.587 |
| NANOG | ESRRB | ENSP00000229307 | ENSP00000370270 | Nanog homeobox; Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5’-TAAT[GT][GT]-3’ or 5 [...] | estrogen-related receptor beta; Nuclear receptor, may regulate ESR1 transcriptional activity | 0.983 |
| NANOG | ESRRG | ENSP00000229307 | ENSP00000386171 | Nanog homeobox; Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5’-TAAT[GT][GT]-3’ or 5 [...] | estrogen-related receptor gamma | 0.527 |
| NANOG | RNF2 | ENSP00000229307 | ENSP00000356480 | Nanog homeobox; Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5’-TAAT[GT][GT]-3’ or 5 [...] | ring finger protein 2; E3 ubiquitin-protein ligase that mediates monoubiquitination of ’Lys-119’ of histone H2A, thereby playing a central role in histone code and gene regulation. H2A ’Lys-119’ ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, includ [...] | 0.452 |
| NANOG | TFCP2L1 | ENSP00000229307 | ENSP00000263707 | Nanog homeobox; Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5’-TAAT[GT][GT]-3’ or 5 [...] | transcription factor CP2-like 1; Transcriptional suppressor. May suppress UBP1-mediated transcriptional activation. Required for normal duct development in the salivary gland and kidney (By similarity). Modulates the placental expression of CYP11A1 | 0.945 |
| NANOG | UBP1 | ENSP00000229307 | ENSP00000283628 | Nanog homeobox; Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5’-TAAT[GT][GT]-3’ or 5 [...] | upstream binding protein 1 (LBP-1a); Functions as a transcriptional activator in a promoter context-dependent manner. Modulates the placental expression of CYP11A1. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2 (By similarity). Involved in regulation of the alpha-globin gene in erythroid cells. Binds strongly to sequences around the HIV-1 initiation site and weakly over the TATA-box. Represses HIV-1 transcription by inhibiting the binding of TFIID to the TATA-box | 0.435 |
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