| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DLG2 | GRID2 | ENSP00000365272 | ENSP00000282020 | discs, large homolog 2 (Drosophila); Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity) | glutamate receptor, ionotropic, delta 2; Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists | 0.740 |
| DLG2 | GRIN2A | ENSP00000365272 | ENSP00000332549 | discs, large homolog 2 (Drosophila); Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity) | glutamate receptor, ionotropic, N-methyl D-aspartate 2A; NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits | 0.983 |
| DLG2 | PTPN4 | ENSP00000365272 | ENSP00000263708 | discs, large homolog 2 (Drosophila); Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity) | protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte); May act at junctions between the membrane and the cytoskeleton | 0.634 |
| GRID2 | DLG2 | ENSP00000282020 | ENSP00000365272 | glutamate receptor, ionotropic, delta 2; Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists | discs, large homolog 2 (Drosophila); Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity) | 0.740 |
| GRID2 | GRID2IP | ENSP00000282020 | ENSP00000397351 | glutamate receptor, ionotropic, delta 2; Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists | glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein; Postsynaptic scaffolding protein at the parallel fiber- Purkinje cell synapse, where it may serve to link GRID2 with actin cytoskeleton and various signaling molecules (By similarity) | 0.987 |
| GRID2 | GRIN2A | ENSP00000282020 | ENSP00000332549 | glutamate receptor, ionotropic, delta 2; Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists | glutamate receptor, ionotropic, N-methyl D-aspartate 2A; NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits | 0.612 |
| GRID2 | PTPN4 | ENSP00000282020 | ENSP00000263708 | glutamate receptor, ionotropic, delta 2; Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists | protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte); May act at junctions between the membrane and the cytoskeleton | 0.703 |
| GRID2IP | GRID2 | ENSP00000397351 | ENSP00000282020 | glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein; Postsynaptic scaffolding protein at the parallel fiber- Purkinje cell synapse, where it may serve to link GRID2 with actin cytoskeleton and various signaling molecules (By similarity) | glutamate receptor, ionotropic, delta 2; Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists | 0.987 |
| GRID2IP | PTPN4 | ENSP00000397351 | ENSP00000263708 | glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein; Postsynaptic scaffolding protein at the parallel fiber- Purkinje cell synapse, where it may serve to link GRID2 with actin cytoskeleton and various signaling molecules (By similarity) | protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte); May act at junctions between the membrane and the cytoskeleton | 0.583 |
| GRIN2A | DLG2 | ENSP00000332549 | ENSP00000365272 | glutamate receptor, ionotropic, N-methyl D-aspartate 2A; NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits | discs, large homolog 2 (Drosophila); Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity) | 0.983 |
| GRIN2A | GRID2 | ENSP00000332549 | ENSP00000282020 | glutamate receptor, ionotropic, N-methyl D-aspartate 2A; NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits | glutamate receptor, ionotropic, delta 2; Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists | 0.612 |
| GRIN2A | PTPN4 | ENSP00000332549 | ENSP00000263708 | glutamate receptor, ionotropic, N-methyl D-aspartate 2A; NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits | protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte); May act at junctions between the membrane and the cytoskeleton | 0.621 |
| MAPK12 | PTPN4 | ENSP00000215659 | ENSP00000263708 | mitogen-activated protein kinase 12; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstre [...] | protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte); May act at junctions between the membrane and the cytoskeleton | 0.795 |
| PRSS1 | PTPN4 | ENSP00000308720 | ENSP00000263708 | protease, serine, 1 (trypsin 1) | protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte); May act at junctions between the membrane and the cytoskeleton | 0.576 |
| PTPN4 | DLG2 | ENSP00000263708 | ENSP00000365272 | protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte); May act at junctions between the membrane and the cytoskeleton | discs, large homolog 2 (Drosophila); Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity) | 0.634 |
| PTPN4 | GRID2 | ENSP00000263708 | ENSP00000282020 | protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte); May act at junctions between the membrane and the cytoskeleton | glutamate receptor, ionotropic, delta 2; Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists | 0.703 |
| PTPN4 | GRID2IP | ENSP00000263708 | ENSP00000397351 | protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte); May act at junctions between the membrane and the cytoskeleton | glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein; Postsynaptic scaffolding protein at the parallel fiber- Purkinje cell synapse, where it may serve to link GRID2 with actin cytoskeleton and various signaling molecules (By similarity) | 0.583 |
| PTPN4 | GRIN2A | ENSP00000263708 | ENSP00000332549 | protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte); May act at junctions between the membrane and the cytoskeleton | glutamate receptor, ionotropic, N-methyl D-aspartate 2A; NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits | 0.621 |
| PTPN4 | MAPK12 | ENSP00000263708 | ENSP00000215659 | protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte); May act at junctions between the membrane and the cytoskeleton | mitogen-activated protein kinase 12; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstre [...] | 0.795 |
| PTPN4 | PRSS1 | ENSP00000263708 | ENSP00000308720 | protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte); May act at junctions between the membrane and the cytoskeleton | protease, serine, 1 (trypsin 1) | 0.576 |
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