Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | EPB41L5 | erythrocyte membrane protein band 4.1 like 5; May contribute to the correct positioning of tight junctions during the establishment of polarity in epithelial cells (733 aa) | ||||||||||||
Predicted Functional Partners:
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 | CRB2 | crumbs homolog 2 (Drosophila); May play a role in polarized cells morphogenesis (1285 aa) |
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0.818 | |||||||||
 | CRB3 | crumbs homolog 3 (Drosophila); Involved in the establishment of cell polarity in mammalian epithelial cells. Regulates the morphogenesis of tight junctions (123 aa) |
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0.758 | ||||||||||
 | NXN | nucleoredoxin; Functions as a redox-dependent negative regulator of the Wnt signaling pathway, possibly by preventing ubiquitination of DVL3 by the BCR(KLHL12) complex. May also function as a transcriptional regulator act as a regulator of protein phosphatase 2A (PP2A) (By similarity) (435 aa) |
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0.749 | ||||||||||
 | MPP5 | membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5); May play a role in tight junctions biogenesis and in the establishment of cell polarity in epithelial cells. May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter. Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (By similarity) (675 aa) |
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0.732 | ||||||||||
 | CRB1 | crumbs homolog 1 (Drosophila) (1406 aa) |
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0.681 | |||||||||
 | UBC | ubiquitin C (685 aa) |
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0.620 | ||||||||||
 | NPHS1 | nephrosis 1, congenital, Finnish type (nephrin); Seems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the actin cytoskeleton. Plays a role in skeletal muscle formation through regulation of myoblast fusion (By similarity) (1241 aa) |
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0.590 | ||||||||||
 | INADL | InaD-like (Drosophila) (1801 aa) |
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0.590 | ||||||||||
 | NPHS2 | nephrosis 2, idiopathic, steroid-resistant (podocin); Plays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma membrane and the cytoskeleton (383 aa) |
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0.583 | ||||||||||
 | CD93 | CD93 molecule; Receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). May mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens. May play a role in intercellular adhesion (652 aa) |
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0.576 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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