node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CNOT6L | SRBD1 | ENSP00000264903 | ENSP00000263736 | CCR4-NOT transcription complex, subunit 6-like; Has 3’-5’ poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in the deadenylation-dependent degradation of mRNAs through the 3 [...] | S1 RNA binding domain 1 | 0.620 |
CNOT6L | SUPT5H | ENSP00000264903 | ENSP00000404029 | CCR4-NOT transcription complex, subunit 6-like; Has 3’-5’ poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in the deadenylation-dependent degradation of mRNAs through the 3 [...] | suppressor of Ty 5 homolog (S. cerevisiae); Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promot [...] | 0.426 |
ELOVL5 | SRBD1 | ENSP00000438095 | ENSP00000263736 | ELOVL fatty acid elongase 5 | S1 RNA binding domain 1 | 0.680 |
ELOVL5 | TMCO1 | ENSP00000438095 | ENSP00000375975 | ELOVL fatty acid elongase 5 | transmembrane and coiled-coil domains 1 | 0.475 |
GALE | SRBD1 | ENSP00000363621 | ENSP00000263736 | UDP-galactose-4-epimerase; Catalyzes two distinct but analogous reactions- the epimerization of UDP-glucose to UDP-galactose and the epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine | S1 RNA binding domain 1 | 0.643 |
IWS1 | SRBD1 | ENSP00000295321 | ENSP00000263736 | IWS1 homolog (S. cerevisiae) | S1 RNA binding domain 1 | 0.750 |
IWS1 | SSRP1 | ENSP00000295321 | ENSP00000278412 | IWS1 homolog (S. cerevisiae) | structure specific recognition protein 1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the ree [...] | 0.488 |
IWS1 | SUPT5H | ENSP00000295321 | ENSP00000404029 | IWS1 homolog (S. cerevisiae) | suppressor of Ty 5 homolog (S. cerevisiae); Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promot [...] | 0.883 |
SART3 | SRBD1 | ENSP00000228284 | ENSP00000263736 | squamous cell carcinoma antigen recognized by T cells 3; Regulates Tat transactivation activity through direct interaction. May be a cellular factor for HIV-1 gene expression and viral replication | S1 RNA binding domain 1 | 0.748 |
SRBD1 | CNOT6L | ENSP00000263736 | ENSP00000264903 | S1 RNA binding domain 1 | CCR4-NOT transcription complex, subunit 6-like; Has 3’-5’ poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in the deadenylation-dependent degradation of mRNAs through the 3 [...] | 0.620 |
SRBD1 | ELOVL5 | ENSP00000263736 | ENSP00000438095 | S1 RNA binding domain 1 | ELOVL fatty acid elongase 5 | 0.680 |
SRBD1 | GALE | ENSP00000263736 | ENSP00000363621 | S1 RNA binding domain 1 | UDP-galactose-4-epimerase; Catalyzes two distinct but analogous reactions- the epimerization of UDP-glucose to UDP-galactose and the epimerization of UDP-N-acetylglucosamine to UDP-N- acetylgalactosamine | 0.643 |
SRBD1 | IWS1 | ENSP00000263736 | ENSP00000295321 | S1 RNA binding domain 1 | IWS1 homolog (S. cerevisiae) | 0.750 |
SRBD1 | SART3 | ENSP00000263736 | ENSP00000228284 | S1 RNA binding domain 1 | squamous cell carcinoma antigen recognized by T cells 3; Regulates Tat transactivation activity through direct interaction. May be a cellular factor for HIV-1 gene expression and viral replication | 0.748 |
SRBD1 | SSRP1 | ENSP00000263736 | ENSP00000278412 | S1 RNA binding domain 1 | structure specific recognition protein 1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the ree [...] | 0.712 |
SRBD1 | SUPT5H | ENSP00000263736 | ENSP00000404029 | S1 RNA binding domain 1 | suppressor of Ty 5 homolog (S. cerevisiae); Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promot [...] | 0.929 |
SRBD1 | TAOK1 | ENSP00000263736 | ENSP00000261716 | S1 RNA binding domain 1 | TAO kinase 1; Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK [...] | 0.644 |
SRBD1 | TMCO1 | ENSP00000263736 | ENSP00000375975 | S1 RNA binding domain 1 | transmembrane and coiled-coil domains 1 | 0.711 |
SRBD1 | USP45 | ENSP00000263736 | ENSP00000333376 | S1 RNA binding domain 1 | ubiquitin specific peptidase 45 | 0.740 |
SSRP1 | IWS1 | ENSP00000278412 | ENSP00000295321 | structure specific recognition protein 1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the ree [...] | IWS1 homolog (S. cerevisiae) | 0.488 |