node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABCB11 | ATP8B1 | ENSP00000263817 | ENSP00000283684 | ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes | ATPase, aminophospholipid transporter, class I, type 8B, member 1; May play a role in the transport of aminophospholipids from the outer to the inner leaflet of various membranes and the maintenance of asymmetric distribution of phospholipids in the canicular membrane. May have a role in transport of bile acids into the canaliculus, uptake of bile acids from intestinal contents into intestinal mucosa or both | 0.871 |
ABCB11 | CYP7A1 | ENSP00000263817 | ENSP00000301645 | ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes | cytochrome P450, family 7, subfamily A, polypeptide 1; Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis | 0.824 |
ABCB11 | HAX1 | ENSP00000263817 | ENSP00000329002 | ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes | HCLS1 associated protein X-1; Promotes cell survival. Potentiates GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. May regulate intracellular calcium pools | 0.912 |
ABCB11 | IL6 | ENSP00000263817 | ENSP00000258743 | ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes | interleukin 6 (interferon, beta 2); Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig- secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and [...] | 0.855 |
ABCB11 | NR1H4 | ENSP00000263817 | ENSP00000447149 | ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes | nuclear receptor subfamily 1, group H, member 4; Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus | 0.962 |
ABCB11 | NR1I2 | ENSP00000263817 | ENSP00000336528 | ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes | nuclear receptor subfamily 1, group I, member 2 | 0.957 |
ABCB11 | NR5A2 | ENSP00000263817 | ENSP00000356331 | ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes | nuclear receptor subfamily 5, group A, member 2; Binds to the sequence element 5’-AACGACCGACCTTGAG-3’ of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development | 0.912 |
ABCB11 | SLC10A1 | ENSP00000263817 | ENSP00000216540 | ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes | solute carrier family 10 (sodium/bile acid cotransporter family), member 1; The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium | 0.917 |
ABCB11 | SLCO1A2 | ENSP00000263817 | ENSP00000305974 | ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes | solute carrier organic anion transporter family, member 1A2; Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin | 0.813 |
ABCB11 | SLCO1B1 | ENSP00000263817 | ENSP00000256958 | ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes | solute carrier organic anion transporter family, member 1B1; Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver | 0.851 |
ATP8B1 | ABCB11 | ENSP00000283684 | ENSP00000263817 | ATPase, aminophospholipid transporter, class I, type 8B, member 1; May play a role in the transport of aminophospholipids from the outer to the inner leaflet of various membranes and the maintenance of asymmetric distribution of phospholipids in the canicular membrane. May have a role in transport of bile acids into the canaliculus, uptake of bile acids from intestinal contents into intestinal mucosa or both | ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes | 0.871 |
ATP8B1 | NR1H4 | ENSP00000283684 | ENSP00000447149 | ATPase, aminophospholipid transporter, class I, type 8B, member 1; May play a role in the transport of aminophospholipids from the outer to the inner leaflet of various membranes and the maintenance of asymmetric distribution of phospholipids in the canicular membrane. May have a role in transport of bile acids into the canaliculus, uptake of bile acids from intestinal contents into intestinal mucosa or both | nuclear receptor subfamily 1, group H, member 4; Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus | 0.753 |
ATP8B1 | SLC10A1 | ENSP00000283684 | ENSP00000216540 | ATPase, aminophospholipid transporter, class I, type 8B, member 1; May play a role in the transport of aminophospholipids from the outer to the inner leaflet of various membranes and the maintenance of asymmetric distribution of phospholipids in the canicular membrane. May have a role in transport of bile acids into the canaliculus, uptake of bile acids from intestinal contents into intestinal mucosa or both | solute carrier family 10 (sodium/bile acid cotransporter family), member 1; The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium | 0.533 |
ATP8B1 | SLCO1B1 | ENSP00000283684 | ENSP00000256958 | ATPase, aminophospholipid transporter, class I, type 8B, member 1; May play a role in the transport of aminophospholipids from the outer to the inner leaflet of various membranes and the maintenance of asymmetric distribution of phospholipids in the canicular membrane. May have a role in transport of bile acids into the canaliculus, uptake of bile acids from intestinal contents into intestinal mucosa or both | solute carrier organic anion transporter family, member 1B1; Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver | 0.408 |
CYP7A1 | ABCB11 | ENSP00000301645 | ENSP00000263817 | cytochrome P450, family 7, subfamily A, polypeptide 1; Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis | ATP-binding cassette, sub-family B (MDR/TAP), member 11; Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes | 0.824 |
CYP7A1 | NR1H4 | ENSP00000301645 | ENSP00000447149 | cytochrome P450, family 7, subfamily A, polypeptide 1; Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis | nuclear receptor subfamily 1, group H, member 4; Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus | 0.966 |
CYP7A1 | NR1I2 | ENSP00000301645 | ENSP00000336528 | cytochrome P450, family 7, subfamily A, polypeptide 1; Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis | nuclear receptor subfamily 1, group I, member 2 | 0.947 |
CYP7A1 | NR5A2 | ENSP00000301645 | ENSP00000356331 | cytochrome P450, family 7, subfamily A, polypeptide 1; Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis | nuclear receptor subfamily 5, group A, member 2; Binds to the sequence element 5’-AACGACCGACCTTGAG-3’ of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development | 0.976 |
CYP7A1 | SLC10A1 | ENSP00000301645 | ENSP00000216540 | cytochrome P450, family 7, subfamily A, polypeptide 1; Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis | solute carrier family 10 (sodium/bile acid cotransporter family), member 1; The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium | 0.769 |
CYP7A1 | SLCO1A2 | ENSP00000301645 | ENSP00000305974 | cytochrome P450, family 7, subfamily A, polypeptide 1; Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis | solute carrier organic anion transporter family, member 1A2; Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin | 0.486 |