| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C18orf21 | STK17B | ENSP00000465517 | ENSP00000263955 | chromosome 18 open reading frame 21 | serine/threonine kinase 17b; Phosphorylates myosin light chains (By similarity). Acts as a positive regulator of apoptosis | 0.582 |
| CHP1 | STK17B | ENSP00000335632 | ENSP00000263955 | calcineurin-like EF hand protein 1; Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exc [...] | serine/threonine kinase 17b; Phosphorylates myosin light chains (By similarity). Acts as a positive regulator of apoptosis | 0.975 |
| CHP1 | UBC | ENSP00000335632 | ENSP00000344818 | calcineurin-like EF hand protein 1; Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exc [...] | ubiquitin C | 0.650 |
| CHP2 | STK17B | ENSP00000300113 | ENSP00000263955 | calcineurin-like EF hand protein 2; Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation- induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to t [...] | serine/threonine kinase 17b; Phosphorylates myosin light chains (By similarity). Acts as a positive regulator of apoptosis | 0.610 |
| DAP | STK17B | ENSP00000230895 | ENSP00000263955 | death-associated protein; Negative regulator of autophagy. Involved in mediating interferon-gamma-induced cell death | serine/threonine kinase 17b; Phosphorylates myosin light chains (By similarity). Acts as a positive regulator of apoptosis | 0.568 |
| DAP | UBC | ENSP00000230895 | ENSP00000344818 | death-associated protein; Negative regulator of autophagy. Involved in mediating interferon-gamma-induced cell death | ubiquitin C | 0.500 |
| GPR63 | STK17B | ENSP00000229955 | ENSP00000263955 | G protein-coupled receptor 63; Orphan receptor. May play a role in brain function | serine/threonine kinase 17b; Phosphorylates myosin light chains (By similarity). Acts as a positive regulator of apoptosis | 0.524 |
| MYL12A | MYL9 | ENSP00000217652 | ENSP00000279022 | myosin, light chain 12A, regulatory, non-sarcomeric; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity) | myosin, light chain 9, regulatory; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion | 0.692 |
| MYL12A | STK17B | ENSP00000217652 | ENSP00000263955 | myosin, light chain 12A, regulatory, non-sarcomeric; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity) | serine/threonine kinase 17b; Phosphorylates myosin light chains (By similarity). Acts as a positive regulator of apoptosis | 0.729 |
| MYL12A | UBC | ENSP00000217652 | ENSP00000344818 | myosin, light chain 12A, regulatory, non-sarcomeric; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity) | ubiquitin C | 0.948 |
| MYL12B | MYL9 | ENSP00000237500 | ENSP00000279022 | myosin, light chain 12B, regulatory; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity) | myosin, light chain 9, regulatory; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion | 0.900 |
| MYL12B | STK17B | ENSP00000237500 | ENSP00000263955 | myosin, light chain 12B, regulatory; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity) | serine/threonine kinase 17b; Phosphorylates myosin light chains (By similarity). Acts as a positive regulator of apoptosis | 0.729 |
| MYL12B | UBC | ENSP00000237500 | ENSP00000344818 | myosin, light chain 12B, regulatory; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity) | ubiquitin C | 0.947 |
| MYL9 | MYL12A | ENSP00000279022 | ENSP00000217652 | myosin, light chain 9, regulatory; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion | myosin, light chain 12A, regulatory, non-sarcomeric; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity) | 0.692 |
| MYL9 | MYL12B | ENSP00000279022 | ENSP00000237500 | myosin, light chain 9, regulatory; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion | myosin, light chain 12B, regulatory; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Phosphorylation triggers actin polymerization in vascular smooth muscle. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity) | 0.900 |
| MYL9 | STK17B | ENSP00000279022 | ENSP00000263955 | myosin, light chain 9, regulatory; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion | serine/threonine kinase 17b; Phosphorylates myosin light chains (By similarity). Acts as a positive regulator of apoptosis | 0.729 |
| MYL9 | UBC | ENSP00000279022 | ENSP00000344818 | myosin, light chain 9, regulatory; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion | ubiquitin C | 0.861 |
| STK17B | C18orf21 | ENSP00000263955 | ENSP00000465517 | serine/threonine kinase 17b; Phosphorylates myosin light chains (By similarity). Acts as a positive regulator of apoptosis | chromosome 18 open reading frame 21 | 0.582 |
| STK17B | CHP1 | ENSP00000263955 | ENSP00000335632 | serine/threonine kinase 17b; Phosphorylates myosin light chains (By similarity). Acts as a positive regulator of apoptosis | calcineurin-like EF hand protein 1; Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exc [...] | 0.975 |
| STK17B | CHP2 | ENSP00000263955 | ENSP00000300113 | serine/threonine kinase 17b; Phosphorylates myosin light chains (By similarity). Acts as a positive regulator of apoptosis | calcineurin-like EF hand protein 2; Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation- induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to t [...] | 0.610 |
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