node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BDP1 | BRF1 | ENSP00000351575 | ENSP00000448323 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae) | 0.997 |
BDP1 | GTF3C1 | ENSP00000351575 | ENSP00000348510 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | general transcription factor IIIC, polypeptide 1, alpha 220kDa; Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. Binds to the box B promoter element | 0.998 |
BDP1 | GTF3C2 | ENSP00000351575 | ENSP00000264720 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | general transcription factor IIIC, polypeptide 2, beta 110kDa; Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1 | 0.951 |
BDP1 | GTF3C3 | ENSP00000351575 | ENSP00000263956 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | general transcription factor IIIC, polypeptide 3, 102kDa; Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters | 0.995 |
BDP1 | GTF3C4 | ENSP00000351575 | ENSP00000361219 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | general transcription factor IIIC, polypeptide 4, 90kDa; Essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin. Has histone acetyltransferase activity (HAT) with unique specificity for free and nucleosomal H3. May cooperate with GTF3C5 in facilitating the recruitment of TFIIIB and RNA polymerase through direct interactions with BRF1, POLR3C and POLR3F. May be localized close to the A box | 0.952 |
BDP1 | GTF3C5 | ENSP00000351575 | ENSP00000361180 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | general transcription factor IIIC, polypeptide 5, 63kDa | 0.969 |
BDP1 | POLR3D | ENSP00000351575 | ENSP00000303088 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | polymerase (RNA) III (DNA directed) polypeptide D, 44kDa; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts [...] | 0.961 |
BDP1 | POLR3F | ENSP00000351575 | ENSP00000366828 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct RNA Pol III binding to the TFIIIB-DNA complex. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcript [...] | 0.982 |
BRF1 | BDP1 | ENSP00000448323 | ENSP00000351575 | BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae) | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | 0.997 |
BRF1 | GTF3C1 | ENSP00000448323 | ENSP00000348510 | BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae) | general transcription factor IIIC, polypeptide 1, alpha 220kDa; Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. Binds to the box B promoter element | 0.986 |
BRF1 | GTF3C2 | ENSP00000448323 | ENSP00000264720 | BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae) | general transcription factor IIIC, polypeptide 2, beta 110kDa; Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1 | 0.929 |
BRF1 | GTF3C3 | ENSP00000448323 | ENSP00000263956 | BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae) | general transcription factor IIIC, polypeptide 3, 102kDa; Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters | 0.999 |
BRF1 | GTF3C4 | ENSP00000448323 | ENSP00000361219 | BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae) | general transcription factor IIIC, polypeptide 4, 90kDa; Essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin. Has histone acetyltransferase activity (HAT) with unique specificity for free and nucleosomal H3. May cooperate with GTF3C5 in facilitating the recruitment of TFIIIB and RNA polymerase through direct interactions with BRF1, POLR3C and POLR3F. May be localized close to the A box | 0.988 |
BRF1 | GTF3C5 | ENSP00000448323 | ENSP00000361180 | BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae) | general transcription factor IIIC, polypeptide 5, 63kDa | 0.995 |
BRF1 | GTF3C6 | ENSP00000448323 | ENSP00000357863 | BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae) | general transcription factor IIIC, polypeptide 6, alpha 35kDa; Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters | 0.720 |
BRF1 | POLR3D | ENSP00000448323 | ENSP00000303088 | BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae) | polymerase (RNA) III (DNA directed) polypeptide D, 44kDa; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts [...] | 0.950 |
BRF1 | POLR3F | ENSP00000448323 | ENSP00000366828 | BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae) | polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct RNA Pol III binding to the TFIIIB-DNA complex. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcript [...] | 0.995 |
CPSF2 | GTF3C3 | ENSP00000298875 | ENSP00000263956 | cleavage and polyadenylation specific factor 2, 100kDa; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3’-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Involved in the histone 3’ end pre-mRNA processing | general transcription factor IIIC, polypeptide 3, 102kDa; Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters | 0.998 |
CPSF2 | GTF3C6 | ENSP00000298875 | ENSP00000357863 | cleavage and polyadenylation specific factor 2, 100kDa; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3’-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Involved in the histone 3’ end pre-mRNA processing | general transcription factor IIIC, polypeptide 6, alpha 35kDa; Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters | 0.905 |
GTF3C1 | BDP1 | ENSP00000348510 | ENSP00000351575 | general transcription factor IIIC, polypeptide 1, alpha 220kDa; Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. Binds to the box B promoter element | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | 0.998 |