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STRINGSTRING
ENSG00000248710 ENSG00000248710 TTC30B TTC30B IFT46 IFT46 IFT172 IFT172 IFT52 IFT52 IFT140 IFT140 IFT88 IFT88 IFT57 IFT57 IFT27 IFT27 IFT80 IFT80 IFT81 IFT81
"IFT46" - intraflagellar transport 46 homolog in Homo sapiens
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protein of unknown 3D structure
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Predicted Interactions
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[Homology]
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IFT46intraflagellar transport 46 homolog (Chlamydomonas); Forms part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. May play a role in chondrocyte maturation and skeletogenesis (By similarity) (355 aa)    
Predicted Functional Partners:
IFT27
intraflagellar transport 27 homolog (Chlamydomonas); Possesses GTPase activity (By similarity) (186 aa)
            score_image   0.856
IFT80
intraflagellar transport 80 homolog (Chlamydomonas); Component of the intraflagellar transport (IFT) complex B, which is essential for the development and maintenance of motile and sensory cilia (777 aa)
            score_image   0.843
ENSG00000248710
Uncharacterized protein (948 aa)
            score_image   0.842
IFT52
intraflagellar transport 52 homolog (Chlamydomonas) (437 aa)
            score_image   0.840
IFT88
intraflagellar transport 88 homolog (Chlamydomonas); Involved in primary cilium biogenesis (By similarity) (833 aa)
        score_image   score_image   0.806
IFT140
intraflagellar transport 140 homolog (Chlamydomonas); Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Plays a pivotal role in proper development and function of ciliated cells. Involved in ciliogenesis and cilia maintenance (1462 aa)
            score_image   0.790
IFT172
intraflagellar transport 172 homolog (Chlamydomonas); Required for the maintenance and formation of cilia. Plays an indirect role in hedgehog (Hh) signaling, cilia being required for all activity of the hedgehog pathway (By similarity) (1749 aa)
            score_image   0.760
IFT81
intraflagellar transport 81 homolog (Chlamydomonas); Isoform CDV-1 may be involved in cardiac hypertrophy caused by carnitine deficiency (By similarity) (676 aa)
        score_image   score_image   0.742
IFT57
intraflagellar transport 57 homolog (Chlamydomonas); Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro- apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5’-AAAGACATG-3’ present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear (429 aa)
            score_image   0.735
TTC30B
tetratricopeptide repeat domain 30B; Required for polyglutamylation of axonemal tubulin (By similarity). Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip (By similarity) (665 aa)
            score_image   0.732
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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