SC5DL protein (Homo sapiens) - STRING network view

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SC5DL

sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, S. cerevisiae)-like; Catalyzes a dehydrogenation to introduce C5-6 double bond into lathosterol (299 aa)

Predicted Functional Partners:

DHCR7

0.995

CYP51A1

0.993

FDFT1

0.991

MSMO1

0.988

DHCR24

0.984

HSD17B7

0.980

LSS

0.979

TM7SF2

0.979

LBR

0.971

UBC

0.950

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CYP51A1	DHCR24	ENSP00000003100	ENSP00000360316	cytochrome P450, family 51, subfamily A, polypeptide 1	24-dehydrocholesterol reductase; Catalyzes the reduction of the delta-24 double bond of sterol intermediates. Protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis	0.949
CYP51A1	DHCR7	ENSP00000003100	ENSP00000347717	cytochrome P450, family 51, subfamily A, polypeptide 1	7-dehydrocholesterol reductase; Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC)	0.861
CYP51A1	FDFT1	ENSP00000003100	ENSP00000220584	cytochrome P450, family 51, subfamily A, polypeptide 1	farnesyl-diphosphate farnesyltransferase 1	0.993
CYP51A1	HSD17B7	ENSP00000003100	ENSP00000254521	cytochrome P450, family 51, subfamily A, polypeptide 1	hydroxysteroid (17-beta) dehydrogenase 7; Responsible for the reduction of the keto group on the C-3 of sterols	0.984
CYP51A1	LBR	ENSP00000003100	ENSP00000272163	cytochrome P450, family 51, subfamily A, polypeptide 1	lamin B receptor; Anchors the lamina and the heterochromatin to the inner nuclear membrane	0.992
CYP51A1	LSS	ENSP00000003100	ENSP00000348762	cytochrome P450, family 51, subfamily A, polypeptide 1	lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase); Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus	0.999
CYP51A1	MSMO1	ENSP00000003100	ENSP00000261507	cytochrome P450, family 51, subfamily A, polypeptide 1	methylsterol monooxygenase 1	0.997
CYP51A1	SC5DL	ENSP00000003100	ENSP00000264027	cytochrome P450, family 51, subfamily A, polypeptide 1	sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, S. cerevisiae)-like; Catalyzes a dehydrogenation to introduce C5-6 double bond into lathosterol	0.993
CYP51A1	TM7SF2	ENSP00000003100	ENSP00000279263	cytochrome P450, family 51, subfamily A, polypeptide 1	transmembrane 7 superfamily member 2; Involved in the conversion of lanosterol to cholesterol	0.994
CYP51A1	UBC	ENSP00000003100	ENSP00000344818	cytochrome P450, family 51, subfamily A, polypeptide 1	ubiquitin C	0.986
DHCR24	CYP51A1	ENSP00000360316	ENSP00000003100	24-dehydrocholesterol reductase; Catalyzes the reduction of the delta-24 double bond of sterol intermediates. Protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis	cytochrome P450, family 51, subfamily A, polypeptide 1	0.949
DHCR24	DHCR7	ENSP00000360316	ENSP00000347717	24-dehydrocholesterol reductase; Catalyzes the reduction of the delta-24 double bond of sterol intermediates. Protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis	7-dehydrocholesterol reductase; Production of cholesterol by reduction of C7-C8 double bond of 7-dehydrocholesterol (7-DHC)	0.984
DHCR24	FDFT1	ENSP00000360316	ENSP00000220584	24-dehydrocholesterol reductase; Catalyzes the reduction of the delta-24 double bond of sterol intermediates. Protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis	farnesyl-diphosphate farnesyltransferase 1	0.554
DHCR24	HSD17B7	ENSP00000360316	ENSP00000254521	24-dehydrocholesterol reductase; Catalyzes the reduction of the delta-24 double bond of sterol intermediates. Protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis	hydroxysteroid (17-beta) dehydrogenase 7; Responsible for the reduction of the keto group on the C-3 of sterols	0.478
DHCR24	LBR	ENSP00000360316	ENSP00000272163	24-dehydrocholesterol reductase; Catalyzes the reduction of the delta-24 double bond of sterol intermediates. Protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis	lamin B receptor; Anchors the lamina and the heterochromatin to the inner nuclear membrane	0.636
DHCR24	LSS	ENSP00000360316	ENSP00000348762	24-dehydrocholesterol reductase; Catalyzes the reduction of the delta-24 double bond of sterol intermediates. Protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis	lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase); Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus	0.954
DHCR24	MSMO1	ENSP00000360316	ENSP00000261507	24-dehydrocholesterol reductase; Catalyzes the reduction of the delta-24 double bond of sterol intermediates. Protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis	methylsterol monooxygenase 1	0.953
DHCR24	SC5DL	ENSP00000360316	ENSP00000264027	24-dehydrocholesterol reductase; Catalyzes the reduction of the delta-24 double bond of sterol intermediates. Protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis	sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, S. cerevisiae)-like; Catalyzes a dehydrogenation to introduce C5-6 double bond into lathosterol	0.984
DHCR24	TM7SF2	ENSP00000360316	ENSP00000279263	24-dehydrocholesterol reductase; Catalyzes the reduction of the delta-24 double bond of sterol intermediates. Protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis	transmembrane 7 superfamily member 2; Involved in the conversion of lanosterol to cholesterol	0.972
DHCR24	UBC	ENSP00000360316	ENSP00000344818	24-dehydrocholesterol reductase; Catalyzes the reduction of the delta-24 double bond of sterol intermediates. Protects cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis	ubiquitin C	0.931

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