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PCNT PCNT PAFAH1B1 PAFAH1B1 PLK4 PLK4 TUBB4A TUBB4A CKAP5 CKAP5 TUBA1A TUBA1A TBCE TBCE TUBA1B TUBA1B TBCA TBCA UBC UBC ACTB ACTB
"TUBB4A" - tubulin, beta 4A class IVa in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
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large nodes:
some 3D structure is known or predicted
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query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
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Known Interactions
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from curated databases
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experimentally determined
Predicted Interactions
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fusion edge
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gene co-occurrence
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textmining
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co-expression
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protein homology
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Score
TUBB4Atubulin, beta 4A class IVa; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity) (444 aa)    
Predicted Functional Partners:
UBC
ubiquitin C (685 aa)
        score_image   score_image   0.985
CKAP5
cytoskeleton associated protein 5; Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles (2032 aa)
        score_image score_image score_image   0.977
PCNT
pericentrin; Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome (3336 aa)
          score_image score_image   0.968
PLK4
polo-like kinase 4; Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates ’Ser-151’ of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to u [...] (970 aa)
        score_image score_image score_image   0.966
PAFAH1B1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa); Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet- activating factor (PAF) by removing the acetyl group at the SN-2 position (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated [...] (410 aa)
        score_image score_image score_image   0.965
ACTB
actin, beta (375 aa)
      score_image score_image score_image score_image   0.965
TBCA
tubulin folding cofactor A; Tubulin-folding protein; involved in the early step of the tubulin folding pathway (108 aa)
        score_image score_image score_image   0.964
TBCE
tubulin folding cofactor E; Tubulin-folding protein; involved in the second step of the tubulin folding pathway. Seems to be implicated in the maintenance of the neuronal microtubule network. Involved in regulation of tubulin heterodimer dissociation (527 aa)
        score_image score_image score_image   0.964
TUBA1A
tubulin, alpha 1a; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity) (451 aa)
      score_image score_image score_image score_image score_image 0.962
TUBA1B
tubulin, alpha 1b; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity) (451 aa)
      score_image score_image score_image score_image score_image 0.962
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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