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STRINGSTRING
ITPA ITPA GUK1 GUK1 CTH CTH TK1 TK1 UBC UBC RRM2 RRM2 PNP PNP DGUOK DGUOK PDIA4 PDIA4 RRM2B RRM2B MPV17 MPV17
"DGUOK" - deoxyguanosine kinase in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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white nodes:
second shell of interactors
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Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
DGUOKdeoxyguanosine kinase; Required for the phosphorylation of several deoxyribonucleosides and certain nucleoside analogs widely employed as antiviral and chemotherapeutic agents (277 aa)    
Predicted Functional Partners:
GUK1
guanylate kinase 1; Essential for recycling GMP and indirectly, cGMP (241 aa)
           score_image score_image   0.921
RRM2B
ribonucleotide reductase M2 B (TP53 inducible) (351 aa)
       score_image     score_image   0.920
ITPA
inosine triphosphatase (nucleoside triphosphate pyrophosphatase) (194 aa)
           score_image score_image   0.908
PNP
purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) (289 aa)
           score_image     0.900
TK1
thymidine kinase 1, soluble (234 aa)
     score_image score_image     score_image   0.873
CTH
cystathionase (cystathionine gamma-lyase); Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration [...] (405 aa)
             score_image   0.867
UBC
ubiquitin C (685 aa)
         score_image   score_image   0.813
MPV17
MpV17 mitochondrial inner membrane protein; Involved in mitochondria homeostasis. May be involved in the metabolism of reactive oxygen species and control of oxidative phosphorylation and mitochondrial DNA (mtDNA) maintenance (176 aa)
             score_image   0.812
RRM2
ribonucleotide reductase M2; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling (449 aa)
       score_image     score_image   0.771
PDIA4
protein disulfide isomerase family A, member 4 (645 aa)
             score_image   0.751
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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