LOXL3 protein (Homo sapiens) - STRING network view

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LOXL3

lysyl oxidase-like 3 (753 aa)

Predicted Functional Partners:

SNAI1

0.840

HTRA2

0.610

BMP1

0.606

GATAD2B

0.570

COL5A3

0.482

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP1	LOXL3	ENSP00000305714	ENSP00000264094	bone morphogenetic protein 1	lysyl oxidase-like 3	0.606
COL5A3	LOXL3	ENSP00000264828	ENSP00000264094	collagen, type V, alpha 3; Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin	lysyl oxidase-like 3	0.482
GATAD2B	LOXL3	ENSP00000357644	ENSP00000264094	GATA zinc finger domain containing 2B; Transcriptional repressor. Enhances MBD2-mediated repression. Efficient repression requires the presence of GATAD2A. Targets MBD3 to discrete loci in the nucleus	lysyl oxidase-like 3	0.570
HTRA2	LOXL3	ENSP00000258080	ENSP00000264094	HtrA serine peptidase 2; Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive	lysyl oxidase-like 3	0.610
LOXL3	BMP1	ENSP00000264094	ENSP00000305714	lysyl oxidase-like 3	bone morphogenetic protein 1	0.606
LOXL3	COL5A3	ENSP00000264094	ENSP00000264828	lysyl oxidase-like 3	collagen, type V, alpha 3; Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin	0.482
LOXL3	GATAD2B	ENSP00000264094	ENSP00000357644	lysyl oxidase-like 3	GATA zinc finger domain containing 2B; Transcriptional repressor. Enhances MBD2-mediated repression. Efficient repression requires the presence of GATAD2A. Targets MBD3 to discrete loci in the nucleus	0.570
LOXL3	HTRA2	ENSP00000264094	ENSP00000258080	lysyl oxidase-like 3	HtrA serine peptidase 2; Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive	0.610
LOXL3	SNAI1	ENSP00000264094	ENSP00000244050	lysyl oxidase-like 3	snail homolog 1 (Drosophila); Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up- regulation of CDKN2B, possibly by binding to the CD [...]	0.840
SNAI1	LOXL3	ENSP00000244050	ENSP00000264094	snail homolog 1 (Drosophila); Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up- regulation of CDKN2B, possibly by binding to the CD [...]	lysyl oxidase-like 3	0.840

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