| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ANKAR | OSGEPL1 | ENSP00000313513 | ENSP00000264151 | ankyrin and armadillo repeat containing | O-sialoglycoprotein endopeptidase-like 1; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) | 0.861 |
| ANKAR | TMEM194B | ENSP00000313513 | ENSP00000386292 | ankyrin and armadillo repeat containing | transmembrane protein 194B | 0.700 |
| ANKAR | TMF1 | ENSP00000313513 | ENSP00000381567 | ankyrin and armadillo repeat containing | TATA element modulatory factor 1; Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes- one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP) | 0.860 |
| IBA57 | OSGEPL1 | ENSP00000355672 | ENSP00000264151 | IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae); Required for normal heme biosynthesis (By similarity) | O-sialoglycoprotein endopeptidase-like 1; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) | 0.611 |
| IBA57 | PCBD1 | ENSP00000355672 | ENSP00000299299 | IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae); Required for normal heme biosynthesis (By similarity) | pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha; Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. Coactivator for HNF1A-dependent transcription. Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity | 0.500 |
| OSGEPL1 | ANKAR | ENSP00000264151 | ENSP00000313513 | O-sialoglycoprotein endopeptidase-like 1; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) | ankyrin and armadillo repeat containing | 0.861 |
| OSGEPL1 | IBA57 | ENSP00000264151 | ENSP00000355672 | O-sialoglycoprotein endopeptidase-like 1; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) | IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae); Required for normal heme biosynthesis (By similarity) | 0.611 |
| OSGEPL1 | PCBD1 | ENSP00000264151 | ENSP00000299299 | O-sialoglycoprotein endopeptidase-like 1; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) | pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha; Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. Coactivator for HNF1A-dependent transcription. Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity | 0.598 |
| OSGEPL1 | TFB1M | ENSP00000264151 | ENSP00000356134 | O-sialoglycoprotein endopeptidase-like 1; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) | transcription factor B1, mitochondrial; S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity | 0.583 |
| OSGEPL1 | TMEM194B | ENSP00000264151 | ENSP00000386292 | O-sialoglycoprotein endopeptidase-like 1; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) | transmembrane protein 194B | 0.581 |
| OSGEPL1 | TMF1 | ENSP00000264151 | ENSP00000381567 | O-sialoglycoprotein endopeptidase-like 1; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) | TATA element modulatory factor 1; Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes- one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP) | 0.728 |
| OSGEPL1 | TP53RK | ENSP00000264151 | ENSP00000361186 | O-sialoglycoprotein endopeptidase-like 1; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) | TP53 regulating kinase; Protein kinase that phosphorylates ’Ser-15’ of p53/TP53 protein and may therefore participate in its activation | 0.950 |
| OSGEPL1 | TPRKB | ENSP00000264151 | ENSP00000272424 | O-sialoglycoprotein endopeptidase-like 1; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) | TP53RK binding protein | 0.835 |
| OSGEPL1 | TRMT5 | ENSP00000264151 | ENSP00000261249 | O-sialoglycoprotein endopeptidase-like 1; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) | tRNA methyltransferase 5 homolog (S. cerevisiae); Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5’ of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding | 0.582 |
| OSGEPL1 | YRDC | ENSP00000264151 | ENSP00000362135 | O-sialoglycoprotein endopeptidase-like 1; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) | yrdC domain containing (E. coli); May regulate the activity of some transporters (By similarity) | 0.808 |
| PCBD1 | IBA57 | ENSP00000299299 | ENSP00000355672 | pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha; Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. Coactivator for HNF1A-dependent transcription. Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity | IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae); Required for normal heme biosynthesis (By similarity) | 0.500 |
| PCBD1 | OSGEPL1 | ENSP00000299299 | ENSP00000264151 | pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha; Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. Coactivator for HNF1A-dependent transcription. Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity | O-sialoglycoprotein endopeptidase-like 1; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) | 0.598 |
| TFB1M | OSGEPL1 | ENSP00000356134 | ENSP00000264151 | transcription factor B1, mitochondrial; S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity | O-sialoglycoprotein endopeptidase-like 1; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) | 0.583 |
| TMEM194B | ANKAR | ENSP00000386292 | ENSP00000313513 | transmembrane protein 194B | ankyrin and armadillo repeat containing | 0.700 |
| TMEM194B | OSGEPL1 | ENSP00000386292 | ENSP00000264151 | transmembrane protein 194B | O-sialoglycoprotein endopeptidase-like 1; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) | 0.581 |
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