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STRINGSTRING
PRPS2 PRPS2 PRPS1L1 PRPS1L1 PPAT PPAT GART GART GLS GLS PAICS PAICS CAD CAD PFAS PFAS GLUL GLUL ADSL ADSL ATIC ATIC
"PPAT" - phosphoribosyl pyrophosphate amidotransferase in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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white nodes:
second shell of interactors
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Known Interactions
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from curated databases
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experimentally determined
Predicted Interactions
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fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
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textmining
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co-expression
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protein homology
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Score
PPATphosphoribosyl pyrophosphate amidotransferase (517 aa)    
Predicted Functional Partners:
GART
phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase (1010 aa)
score_image   score_image score_image     score_image   0.999
PAICS
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase (432 aa)
score_image   score_image score_image score_image   score_image   0.998
PFAS
phosphoribosylformylglycinamidine synthase (1338 aa)
score_image     score_image     score_image   0.995
CAD
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) (2225 aa)
score_image     score_image   score_image score_image   0.993
ATIC
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis (592 aa)
score_image   score_image score_image score_image   score_image   0.988
ADSL
adenylosuccinate lyase; Catalyzes two non-sequential steps in de novo AMP synthesis- converts (S)-2-(5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate (484 aa)
score_image     score_image score_image   score_image   0.964
PRPS2
phosphoribosyl pyrophosphate synthetase 2; Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis (321 aa)
      score_image   score_image score_image   0.955
PRPS1L1
phosphoribosyl pyrophosphate synthetase 1-like 1; Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis (318 aa)
      score_image   score_image score_image   0.937
GLUL
glutamate-ammonia ligase; This enzyme has 2 functions- it catalyzes the production of glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent manner (By similarity). Essential for proliferation of fetal skin fibroblasts (373 aa)
          score_image score_image   0.937
GLS
glutaminase; Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. Isoform 2 lacks catalytic activity (669 aa)
          score_image score_image   0.925
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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