UPK1B protein (Homo sapiens) - STRING network view

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UPK1B

uroplakin 1B; Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity) (260 aa)

Predicted Functional Partners:

UPK3B

0.979

UPK3A

0.966

UPK2

0.889

PPARG

0.806

TSPAN4

0.667

CD151

0.640

CD53

0.609

SCARB2

0.609

CD37

0.607

CD9

0.577

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD151	UPK1B	ENSP00000324101	ENSP00000264234	CD151 molecule (Raph blood group); Essential for the proper assembly of the glomerular and tubular basement membranes in kidney	uroplakin 1B; Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity)	0.640
CD151	UPK3A	ENSP00000324101	ENSP00000216211	CD151 molecule (Raph blood group); Essential for the proper assembly of the glomerular and tubular basement membranes in kidney	uroplakin 3A; Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence (By similarity)	0.653
CD37	UPK1B	ENSP00000325708	ENSP00000264234	CD37 molecule	uroplakin 1B; Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity)	0.607
CD37	UPK3A	ENSP00000325708	ENSP00000216211	CD37 molecule	uroplakin 3A; Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence (By similarity)	0.607
CD53	CD9	ENSP00000271324	ENSP00000009180	CD53 molecule; May be involved in growth regulation in hematopoietic cells	CD9 molecule; Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell adhesion, cell motility and tumor metastasis. Required for sperm-egg fusion	0.657
CD53	UPK1B	ENSP00000271324	ENSP00000264234	CD53 molecule; May be involved in growth regulation in hematopoietic cells	uroplakin 1B; Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity)	0.609
CD53	UPK3A	ENSP00000271324	ENSP00000216211	CD53 molecule; May be involved in growth regulation in hematopoietic cells	uroplakin 3A; Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence (By similarity)	0.609
CD9	CD53	ENSP00000009180	ENSP00000271324	CD9 molecule; Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell adhesion, cell motility and tumor metastasis. Required for sperm-egg fusion	CD53 molecule; May be involved in growth regulation in hematopoietic cells	0.657
CD9	SCARB2	ENSP00000009180	ENSP00000264896	CD9 molecule; Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell adhesion, cell motility and tumor metastasis. Required for sperm-egg fusion	scavenger receptor class B, member 2; Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting	0.681
CD9	TSPAN4	ENSP00000009180	ENSP00000380552	CD9 molecule; Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell adhesion, cell motility and tumor metastasis. Required for sperm-egg fusion	tetraspanin 4	0.644
CD9	UPK1B	ENSP00000009180	ENSP00000264234	CD9 molecule; Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell adhesion, cell motility and tumor metastasis. Required for sperm-egg fusion	uroplakin 1B; Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity)	0.577
CD9	UPK3A	ENSP00000009180	ENSP00000216211	CD9 molecule; Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell adhesion, cell motility and tumor metastasis. Required for sperm-egg fusion	uroplakin 3A; Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence (By similarity)	0.561
PPARG	UPK1B	ENSP00000287820	ENSP00000264234	peroxisome proliferator-activated receptor gamma	uroplakin 1B; Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity)	0.806
SCARB2	CD9	ENSP00000264896	ENSP00000009180	scavenger receptor class B, member 2; Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting	CD9 molecule; Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell adhesion, cell motility and tumor metastasis. Required for sperm-egg fusion	0.681
SCARB2	UPK1B	ENSP00000264896	ENSP00000264234	scavenger receptor class B, member 2; Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting	uroplakin 1B; Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity)	0.609
TSPAN4	CD9	ENSP00000380552	ENSP00000009180	tetraspanin 4	CD9 molecule; Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell adhesion, cell motility and tumor metastasis. Required for sperm-egg fusion	0.644
TSPAN4	UPK1B	ENSP00000380552	ENSP00000264234	tetraspanin 4	uroplakin 1B; Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity)	0.667
TSPAN4	UPK3A	ENSP00000380552	ENSP00000216211	tetraspanin 4	uroplakin 3A; Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence (By similarity)	0.661
UPK1B	CD151	ENSP00000264234	ENSP00000324101	uroplakin 1B; Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity)	CD151 molecule (Raph blood group); Essential for the proper assembly of the glomerular and tubular basement membranes in kidney	0.640
UPK1B	CD37	ENSP00000264234	ENSP00000325708	uroplakin 1B; Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity)	CD37 molecule	0.607

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