node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FAM174B | LIPT1 | ENSP00000329040 | ENSP00000342071 | family with sequence similarity 174, member B | lipoyltransferase 1; Catalyzes the transfer of the lipoyl group from lipoyl- AMP to the specific lysine residue of lipoyl domains of lipoate- dependent enzymes (By similarity) | 0.678 |
FAM174B | TXNDC9 | ENSP00000329040 | ENSP00000264255 | family with sequence similarity 174, member B | thioredoxin domain containing 9; Significantly diminishes the chaperonin TCP1 complex ATPase activity, thus negatively impacts protein folding, including that of actin or tubulin | 0.664 |
FBXL17 | TXNDC9 | ENSP00000437464 | ENSP00000264255 | F-box and leucine-rich repeat protein 17; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity) | thioredoxin domain containing 9; Significantly diminishes the chaperonin TCP1 complex ATPase activity, thus negatively impacts protein folding, including that of actin or tubulin | 0.657 |
FBXL17 | UBC | ENSP00000437464 | ENSP00000344818 | F-box and leucine-rich repeat protein 17; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity) | ubiquitin C | 0.514 |
HUWE1 | TXNDC9 | ENSP00000262854 | ENSP00000264255 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | thioredoxin domain containing 9; Significantly diminishes the chaperonin TCP1 complex ATPase activity, thus negatively impacts protein folding, including that of actin or tubulin | 0.673 |
HUWE1 | UBC | ENSP00000262854 | ENSP00000344818 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | ubiquitin C | 0.999 |
LIPT1 | FAM174B | ENSP00000342071 | ENSP00000329040 | lipoyltransferase 1; Catalyzes the transfer of the lipoyl group from lipoyl- AMP to the specific lysine residue of lipoyl domains of lipoate- dependent enzymes (By similarity) | family with sequence similarity 174, member B | 0.678 |
LIPT1 | TXNDC9 | ENSP00000342071 | ENSP00000264255 | lipoyltransferase 1; Catalyzes the transfer of the lipoyl group from lipoyl- AMP to the specific lysine residue of lipoyl domains of lipoate- dependent enzymes (By similarity) | thioredoxin domain containing 9; Significantly diminishes the chaperonin TCP1 complex ATPase activity, thus negatively impacts protein folding, including that of actin or tubulin | 0.735 |
LIPT1 | UBC | ENSP00000342071 | ENSP00000344818 | lipoyltransferase 1; Catalyzes the transfer of the lipoyl group from lipoyl- AMP to the specific lysine residue of lipoyl domains of lipoate- dependent enzymes (By similarity) | ubiquitin C | 0.490 |
ST5 | TXNDC9 | ENSP00000319678 | ENSP00000264255 | suppression of tumorigenicity 5 | thioredoxin domain containing 9; Significantly diminishes the chaperonin TCP1 complex ATPase activity, thus negatively impacts protein folding, including that of actin or tubulin | 0.820 |
TCP1 | TXNDC9 | ENSP00000317334 | ENSP00000264255 | t-complex 1; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin | thioredoxin domain containing 9; Significantly diminishes the chaperonin TCP1 complex ATPase activity, thus negatively impacts protein folding, including that of actin or tubulin | 0.781 |
TCP1 | UBC | ENSP00000317334 | ENSP00000344818 | t-complex 1; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin | ubiquitin C | 0.993 |
TCP1 | VBP1 | ENSP00000317334 | ENSP00000286428 | t-complex 1; Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin | von Hippel-Lindau binding protein 1; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins | 0.499 |
TMX1 | TXNDC9 | ENSP00000393316 | ENSP00000264255 | thioredoxin-related transmembrane protein 1; May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions | thioredoxin domain containing 9; Significantly diminishes the chaperonin TCP1 complex ATPase activity, thus negatively impacts protein folding, including that of actin or tubulin | 0.860 |
TMX1 | UBC | ENSP00000393316 | ENSP00000344818 | thioredoxin-related transmembrane protein 1; May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions | ubiquitin C | 0.921 |
TXNDC9 | FAM174B | ENSP00000264255 | ENSP00000329040 | thioredoxin domain containing 9; Significantly diminishes the chaperonin TCP1 complex ATPase activity, thus negatively impacts protein folding, including that of actin or tubulin | family with sequence similarity 174, member B | 0.664 |
TXNDC9 | FBXL17 | ENSP00000264255 | ENSP00000437464 | thioredoxin domain containing 9; Significantly diminishes the chaperonin TCP1 complex ATPase activity, thus negatively impacts protein folding, including that of actin or tubulin | F-box and leucine-rich repeat protein 17; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity) | 0.657 |
TXNDC9 | HUWE1 | ENSP00000264255 | ENSP00000262854 | thioredoxin domain containing 9; Significantly diminishes the chaperonin TCP1 complex ATPase activity, thus negatively impacts protein folding, including that of actin or tubulin | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.673 |
TXNDC9 | LIPT1 | ENSP00000264255 | ENSP00000342071 | thioredoxin domain containing 9; Significantly diminishes the chaperonin TCP1 complex ATPase activity, thus negatively impacts protein folding, including that of actin or tubulin | lipoyltransferase 1; Catalyzes the transfer of the lipoyl group from lipoyl- AMP to the specific lysine residue of lipoyl domains of lipoate- dependent enzymes (By similarity) | 0.735 |
TXNDC9 | ST5 | ENSP00000264255 | ENSP00000319678 | thioredoxin domain containing 9; Significantly diminishes the chaperonin TCP1 complex ATPase activity, thus negatively impacts protein folding, including that of actin or tubulin | suppression of tumorigenicity 5 | 0.820 |