CRYGD protein (Homo sapiens) - STRING network view

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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protein of unknown 3D structure

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second shell of interactors

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

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Predicted Interactions

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Score

CRYGD

crystallin, gamma D; Crystallins are the dominant structural components of the vertebrate eye lens (174 aa)

Predicted Functional Partners:

CRYAA

0.926

TRNT1

0.814

MAF

0.749

GCNT2

0.728

GGT1

0.722

GGT2

0.720

CRYGC

0.581

CAGE1

0.561

GJA8

0.537

PRDM10

0.535

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CAGE1	CRYGD	ENSP00000425493	ENSP00000264376	cancer antigen 1	crystallin, gamma D; Crystallins are the dominant structural components of the vertebrate eye lens	0.561
CAGE1	GGT1	ENSP00000425493	ENSP00000248923	cancer antigen 1	gamma-glutamyltransferase 1; Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate. Isoform 3 seems to be inactive	0.870
CAGE1	GGT2	ENSP00000425493	ENSP00000385721	cancer antigen 1	gamma-glutamyltransferase 2; Initiates extracellular glutathione (GSH) breakdown; catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors (By similarity)	0.870
CAGE1	PRDM10	ENSP00000425493	ENSP00000351686	cancer antigen 1	PR domain containing 10	0.635
CRYAA	CRYGC	ENSP00000291554	ENSP00000282141	crystallin, alpha A; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions	crystallin, gamma C; Crystallins are the dominant structural components of the vertebrate eye lens	0.978
CRYAA	CRYGD	ENSP00000291554	ENSP00000264376	crystallin, alpha A; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions	crystallin, gamma D; Crystallins are the dominant structural components of the vertebrate eye lens	0.926
CRYAA	GCNT2	ENSP00000291554	ENSP00000265012	crystallin, alpha A; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions	glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group); Branching enzyme that converts linear into branched poly-N-acetyllactosaminoglycans. Introduces the blood group I antigen during embryonic development. It is closely associated with the development and maturation of erythroid cells. The expression of the blood group I antigen in erythrocytes is determined by isoform C	0.459
CRYAA	GJA8	ENSP00000291554	ENSP00000240986	crystallin, alpha A; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions	gap junction protein, alpha 8, 50kDa	0.757
CRYAA	MAF	ENSP00000291554	ENSP00000327048	crystallin, alpha A; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions	v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian); Acts as a transcriptional activator or repressor. Involved in embryonic lens fiber cell development. Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-regulation of crystallin gene during lens fiber cell differentiation. Activates the expression of IL4 in T helper 2 (Th2) cells. Increases T-cell susceptibility to apoptosis by interacting with MYB and decreasing BCL2 expression. Together with PAX6, transactivates strongly the glucagon gene promoter through the G1 element. Ac [...]	0.566
CRYGC	CRYAA	ENSP00000282141	ENSP00000291554	crystallin, gamma C; Crystallins are the dominant structural components of the vertebrate eye lens	crystallin, alpha A; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions	0.978
CRYGC	CRYGD	ENSP00000282141	ENSP00000264376	crystallin, gamma C; Crystallins are the dominant structural components of the vertebrate eye lens	crystallin, gamma D; Crystallins are the dominant structural components of the vertebrate eye lens	0.581
CRYGC	GJA8	ENSP00000282141	ENSP00000240986	crystallin, gamma C; Crystallins are the dominant structural components of the vertebrate eye lens	gap junction protein, alpha 8, 50kDa	0.723
CRYGC	MAF	ENSP00000282141	ENSP00000327048	crystallin, gamma C; Crystallins are the dominant structural components of the vertebrate eye lens	v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian); Acts as a transcriptional activator or repressor. Involved in embryonic lens fiber cell development. Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-regulation of crystallin gene during lens fiber cell differentiation. Activates the expression of IL4 in T helper 2 (Th2) cells. Increases T-cell susceptibility to apoptosis by interacting with MYB and decreasing BCL2 expression. Together with PAX6, transactivates strongly the glucagon gene promoter through the G1 element. Ac [...]	0.610
CRYGD	CAGE1	ENSP00000264376	ENSP00000425493	crystallin, gamma D; Crystallins are the dominant structural components of the vertebrate eye lens	cancer antigen 1	0.561
CRYGD	CRYAA	ENSP00000264376	ENSP00000291554	crystallin, gamma D; Crystallins are the dominant structural components of the vertebrate eye lens	crystallin, alpha A; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions	0.926
CRYGD	CRYGC	ENSP00000264376	ENSP00000282141	crystallin, gamma D; Crystallins are the dominant structural components of the vertebrate eye lens	crystallin, gamma C; Crystallins are the dominant structural components of the vertebrate eye lens	0.581
CRYGD	GCNT2	ENSP00000264376	ENSP00000265012	crystallin, gamma D; Crystallins are the dominant structural components of the vertebrate eye lens	glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group); Branching enzyme that converts linear into branched poly-N-acetyllactosaminoglycans. Introduces the blood group I antigen during embryonic development. It is closely associated with the development and maturation of erythroid cells. The expression of the blood group I antigen in erythrocytes is determined by isoform C	0.728
CRYGD	GGT1	ENSP00000264376	ENSP00000248923	crystallin, gamma D; Crystallins are the dominant structural components of the vertebrate eye lens	gamma-glutamyltransferase 1; Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate. Isoform 3 seems to be inactive	0.722
CRYGD	GGT2	ENSP00000264376	ENSP00000385721	crystallin, gamma D; Crystallins are the dominant structural components of the vertebrate eye lens	gamma-glutamyltransferase 2; Initiates extracellular glutathione (GSH) breakdown; catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors (By similarity)	0.720
CRYGD	GJA8	ENSP00000264376	ENSP00000240986	crystallin, gamma D; Crystallins are the dominant structural components of the vertebrate eye lens	gap junction protein, alpha 8, 50kDa	0.537

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