node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GUCY1A2 | GUCY1A3 | ENSP00000431245 | ENSP00000296518 | guanylate cyclase 1, soluble, alpha 2; Has guanylyl cyclase on binding to the beta-1 subunit | guanylate cyclase 1, soluble, alpha 3 | 0.905 |
GUCY1A2 | GUCY1B3 | ENSP00000431245 | ENSP00000264424 | guanylate cyclase 1, soluble, alpha 2; Has guanylyl cyclase on binding to the beta-1 subunit | guanylate cyclase 1, soluble, beta 3 | 0.960 |
GUCY1A2 | PRKG2 | ENSP00000431245 | ENSP00000264399 | guanylate cyclase 1, soluble, alpha 2; Has guanylyl cyclase on binding to the beta-1 subunit | protein kinase, cGMP-dependent, type II | 0.926 |
GUCY1A3 | GUCY1A2 | ENSP00000296518 | ENSP00000431245 | guanylate cyclase 1, soluble, alpha 3 | guanylate cyclase 1, soluble, alpha 2; Has guanylyl cyclase on binding to the beta-1 subunit | 0.905 |
GUCY1A3 | GUCY1B3 | ENSP00000296518 | ENSP00000264424 | guanylate cyclase 1, soluble, alpha 3 | guanylate cyclase 1, soluble, beta 3 | 0.992 |
GUCY1A3 | PRKG2 | ENSP00000296518 | ENSP00000264399 | guanylate cyclase 1, soluble, alpha 3 | protein kinase, cGMP-dependent, type II | 0.935 |
GUCY1B3 | GUCY1A2 | ENSP00000264424 | ENSP00000431245 | guanylate cyclase 1, soluble, beta 3 | guanylate cyclase 1, soluble, alpha 2; Has guanylyl cyclase on binding to the beta-1 subunit | 0.960 |
GUCY1B3 | GUCY1A3 | ENSP00000264424 | ENSP00000296518 | guanylate cyclase 1, soluble, beta 3 | guanylate cyclase 1, soluble, alpha 3 | 0.992 |
GUCY1B3 | PRKG2 | ENSP00000264424 | ENSP00000264399 | guanylate cyclase 1, soluble, beta 3 | protein kinase, cGMP-dependent, type II | 0.933 |
KCNMA1 | PRKG2 | ENSP00000385806 | ENSP00000264399 | potassium large conductance calcium-activated channel, subfamily M, alpha member 1 | protein kinase, cGMP-dependent, type II | 0.946 |
MRVI1 | PRKG2 | ENSP00000412130 | ENSP00000264399 | murine retrovirus integration site 1 homolog; Plays a role as NO/PRKG1-dependent regulator of IP3- induced calcium release; its phosphorylation by PRKG1 inhibits bradykinin and IP3-induced calcium release from intracellular stores. Recruits PRKG1 to the endoplasmic reticulum and may mediate the assembly of PRKG1 and ITPR1 in a macrocomplex. Involved in PRKG1 signaling cascade leading to inhibition of platelet activation and aggregation. Mediates also NO-dependent inhibition of calcium signaling in gastrointestinal smooth muscle contributing to NO-dependent relaxation | protein kinase, cGMP-dependent, type II | 0.946 |
MRVI1 | VASP | ENSP00000412130 | ENSP00000245932 | murine retrovirus integration site 1 homolog; Plays a role as NO/PRKG1-dependent regulator of IP3- induced calcium release; its phosphorylation by PRKG1 inhibits bradykinin and IP3-induced calcium release from intracellular stores. Recruits PRKG1 to the endoplasmic reticulum and may mediate the assembly of PRKG1 and ITPR1 in a macrocomplex. Involved in PRKG1 signaling cascade leading to inhibition of platelet activation and aggregation. Mediates also NO-dependent inhibition of calcium signaling in gastrointestinal smooth muscle contributing to NO-dependent relaxation | vasodilator-stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin- bound actin monomers onto the barbed end [...] | 0.503 |
PLCB3 | PRKG2 | ENSP00000279230 | ENSP00000264399 | phospholipase C, beta 3 (phosphatidylinositol-specific); The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes | protein kinase, cGMP-dependent, type II | 0.933 |
PLCB3 | SLC9A3R2 | ENSP00000279230 | ENSP00000408005 | phospholipase C, beta 3 (phosphatidylinositol-specific); The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes | solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May also act as scaffold protein in the nucleus | 0.961 |
PRKG2 | GUCY1A2 | ENSP00000264399 | ENSP00000431245 | protein kinase, cGMP-dependent, type II | guanylate cyclase 1, soluble, alpha 2; Has guanylyl cyclase on binding to the beta-1 subunit | 0.926 |
PRKG2 | GUCY1A3 | ENSP00000264399 | ENSP00000296518 | protein kinase, cGMP-dependent, type II | guanylate cyclase 1, soluble, alpha 3 | 0.935 |
PRKG2 | GUCY1B3 | ENSP00000264399 | ENSP00000264424 | protein kinase, cGMP-dependent, type II | guanylate cyclase 1, soluble, beta 3 | 0.933 |
PRKG2 | KCNMA1 | ENSP00000264399 | ENSP00000385806 | protein kinase, cGMP-dependent, type II | potassium large conductance calcium-activated channel, subfamily M, alpha member 1 | 0.946 |
PRKG2 | MRVI1 | ENSP00000264399 | ENSP00000412130 | protein kinase, cGMP-dependent, type II | murine retrovirus integration site 1 homolog; Plays a role as NO/PRKG1-dependent regulator of IP3- induced calcium release; its phosphorylation by PRKG1 inhibits bradykinin and IP3-induced calcium release from intracellular stores. Recruits PRKG1 to the endoplasmic reticulum and may mediate the assembly of PRKG1 and ITPR1 in a macrocomplex. Involved in PRKG1 signaling cascade leading to inhibition of platelet activation and aggregation. Mediates also NO-dependent inhibition of calcium signaling in gastrointestinal smooth muscle contributing to NO-dependent relaxation | 0.946 |
PRKG2 | PLCB3 | ENSP00000264399 | ENSP00000279230 | protein kinase, cGMP-dependent, type II | phospholipase C, beta 3 (phosphatidylinositol-specific); The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes | 0.933 |