Full Link:
  • Version:
  • 10.0 (archived version)
STRINGSTRING
PDE9A PDE9A PDE6B PDE6B PDE10A PDE10A GUCY1A2 GUCY1A2 GUCY1A3 GUCY1A3 PDE11A PDE11A PDE6C PDE6C GUCY1B3 GUCY1B3 NOS3 NOS3 PDE5A PDE5A PDE2A PDE2A
"GUCY1B3" - guanylate cyclase 1, soluble, beta 3 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GUCY1B3guanylate cyclase 1, soluble, beta 3 (619 aa)    
Predicted Functional Partners:
GUCY1A3
guanylate cyclase 1, soluble, alpha 3 (690 aa)
    score_image score_image score_image score_image score_image score_image 0.992
NOS3
nitric oxide synthase 3 (endothelial cell); Produces nitric oxide (NO) (By similarity) (1203 aa)
        score_image score_image score_image   0.977
GUCY1A2
guanylate cyclase 1, soluble, alpha 2; Has guanylyl cyclase on binding to the beta-1 subunit (732 aa)
        score_image score_image score_image score_image 0.960
PDE5A
phosphodiesterase 5A, cGMP-specific; Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5’- GMP (875 aa)
        score_image score_image score_image   0.947
PDE2A
phosphodiesterase 2A, cGMP-stimulated; Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (941 aa)
        score_image score_image score_image   0.946
PDE6C
phosphodiesterase 6C, cGMP-specific, cone, alpha prime (858 aa)
        score_image score_image score_image   0.945
PDE10A
phosphodiesterase 10A; Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate (789 aa)
        score_image score_image score_image   0.941
PDE6B
phosphodiesterase 6B, cGMP-specific, rod, beta; This protein participates in processes of transmission and amplification of the visual signal. Necessary for the formation of a functional phosphodiesterase holoenzyme (854 aa)
        score_image score_image score_image   0.940
PDE9A
phosphodiesterase 9A (593 aa)
        score_image score_image score_image   0.940
PDE11A
phosphodiesterase 11A; Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5’-AMP and 5’- GMP, respectively (933 aa)
        score_image score_image score_image   0.940
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Server load: low (30%)