node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AREG | ATF3 | ENSP00000264487 | ENSP00000344352 | amphiregulin | activating transcription factor 3; This protein binds the cAMP response element (CRE) (consensus- 5’-GTGACGT[AC][AG]-3’), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. Isoform 2 activates transcription presumably by sequestering inhibitory cofactors away from the promoters | 0.851 |
AREG | BTC | ENSP00000264487 | ENSP00000379092 | amphiregulin | betacellulin; Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells | 0.879 |
AREG | EGFR | ENSP00000264487 | ENSP00000275493 | amphiregulin | epidermal growth factor receptor | 0.987 |
AREG | ERBB3 | ENSP00000264487 | ENSP00000267101 | amphiregulin | v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian); Binds and is activated by neuregulins and NTAK | 0.960 |
AREG | EREG | ENSP00000264487 | ENSP00000244869 | amphiregulin | epiregulin; Ligand of the EGF receptor/EGFR and ERBB4. May be a mediator of localized cell proliferation. As a mitogen it may stimulate cell proliferation and/or angiogenesis | 0.905 |
AREG | ESR1 | ENSP00000264487 | ENSP00000206249 | amphiregulin | estrogen receptor 1; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA- binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial [...] | 0.903 |
AREG | GAST | ENSP00000264487 | ENSP00000331358 | amphiregulin | gastrin; Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine | 0.866 |
AREG | PGR | ENSP00000264487 | ENSP00000325120 | amphiregulin | progesterone receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation | 0.912 |
AREG | PTGS2 | ENSP00000264487 | ENSP00000356438 | amphiregulin | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase); Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity | 0.897 |
AREG | PTH | ENSP00000264487 | ENSP00000282091 | amphiregulin | parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2- deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells | 0.846 |
ATF3 | AREG | ENSP00000344352 | ENSP00000264487 | activating transcription factor 3; This protein binds the cAMP response element (CRE) (consensus- 5’-GTGACGT[AC][AG]-3’), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. Isoform 2 activates transcription presumably by sequestering inhibitory cofactors away from the promoters | amphiregulin | 0.851 |
ATF3 | EGFR | ENSP00000344352 | ENSP00000275493 | activating transcription factor 3; This protein binds the cAMP response element (CRE) (consensus- 5’-GTGACGT[AC][AG]-3’), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. Isoform 2 activates transcription presumably by sequestering inhibitory cofactors away from the promoters | epidermal growth factor receptor | 0.455 |
ATF3 | PTGS2 | ENSP00000344352 | ENSP00000356438 | activating transcription factor 3; This protein binds the cAMP response element (CRE) (consensus- 5’-GTGACGT[AC][AG]-3’), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. Isoform 2 activates transcription presumably by sequestering inhibitory cofactors away from the promoters | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase); Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity | 0.416 |
BTC | AREG | ENSP00000379092 | ENSP00000264487 | betacellulin; Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells | amphiregulin | 0.879 |
BTC | EGFR | ENSP00000379092 | ENSP00000275493 | betacellulin; Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells | epidermal growth factor receptor | 0.982 |
BTC | ERBB3 | ENSP00000379092 | ENSP00000267101 | betacellulin; Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells | v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian); Binds and is activated by neuregulins and NTAK | 0.813 |
EGFR | AREG | ENSP00000275493 | ENSP00000264487 | epidermal growth factor receptor | amphiregulin | 0.987 |
EGFR | ATF3 | ENSP00000275493 | ENSP00000344352 | epidermal growth factor receptor | activating transcription factor 3; This protein binds the cAMP response element (CRE) (consensus- 5’-GTGACGT[AC][AG]-3’), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. Isoform 2 activates transcription presumably by sequestering inhibitory cofactors away from the promoters | 0.455 |
EGFR | BTC | ENSP00000275493 | ENSP00000379092 | epidermal growth factor receptor | betacellulin; Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells | 0.982 |
EGFR | ERBB3 | ENSP00000275493 | ENSP00000267101 | epidermal growth factor receptor | v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian); Binds and is activated by neuregulins and NTAK | 0.999 |