| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BCL6 | FOXP3 | ENSP00000232014 | ENSP00000365380 | B-cell CLL/lymphoma 6; Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis | forkhead box P3; Probable transcription factor. Plays a critical role in the control of immune response | 0.957 |
| BCL6 | GZMB | ENSP00000232014 | ENSP00000216341 | B-cell CLL/lymphoma 6; Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1); This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis | 0.874 |
| BCL6 | IL2 | ENSP00000232014 | ENSP00000226730 | B-cell CLL/lymphoma 6; Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis | interleukin 2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells | 0.864 |
| BCL6 | IL21 | ENSP00000232014 | ENSP00000264497 | B-cell CLL/lymphoma 6; Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis | interleukin 21; Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation | 0.910 |
| BCL6 | IL21R | ENSP00000232014 | ENSP00000338010 | B-cell CLL/lymphoma 6; Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis | interleukin 21 receptor; This is a receptor for interleukin-21 | 0.457 |
| BCL6 | STAT3 | ENSP00000232014 | ENSP00000264657 | B-cell CLL/lymphoma 6; Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis | signal transducer and activator of transcription 3 (acute-phase response factor); Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute- phase protein genes. Activated by IL31 through IL31RA. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity | 0.903 |
| BCL6 | TBX21 | ENSP00000232014 | ENSP00000177694 | B-cell CLL/lymphoma 6; Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis | T-box 21; Transcription factor that controls the expression of the TH1 cytokine, interferon-gamma. Initiates TH1 lineage development from naive TH precursor cells both by activating TH1 genetic programs and by repressing the opposing TH2 programs | 0.919 |
| FOXP3 | BCL6 | ENSP00000365380 | ENSP00000232014 | forkhead box P3; Probable transcription factor. Plays a critical role in the control of immune response | B-cell CLL/lymphoma 6; Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis | 0.957 |
| FOXP3 | GZMB | ENSP00000365380 | ENSP00000216341 | forkhead box P3; Probable transcription factor. Plays a critical role in the control of immune response | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1); This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis | 0.943 |
| FOXP3 | IL2 | ENSP00000365380 | ENSP00000226730 | forkhead box P3; Probable transcription factor. Plays a critical role in the control of immune response | interleukin 2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells | 0.995 |
| FOXP3 | IL21 | ENSP00000365380 | ENSP00000264497 | forkhead box P3; Probable transcription factor. Plays a critical role in the control of immune response | interleukin 21; Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation | 0.912 |
| FOXP3 | IL2RG | ENSP00000365380 | ENSP00000363318 | forkhead box P3; Probable transcription factor. Plays a critical role in the control of immune response | interleukin 2 receptor, gamma; Common subunit for the receptors for a variety of interleukins | 0.422 |
| FOXP3 | IL5 | ENSP00000365380 | ENSP00000231454 | forkhead box P3; Probable transcription factor. Plays a critical role in the control of immune response | interleukin 5 (colony-stimulating factor, eosinophil); Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells | 0.414 |
| FOXP3 | PRDM1 | ENSP00000365380 | ENSP00000358092 | forkhead box P3; Probable transcription factor. Plays a critical role in the control of immune response | PR domain containing 1, with ZNF domain; Transcriptional repressor that binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells | 0.453 |
| FOXP3 | STAT3 | ENSP00000365380 | ENSP00000264657 | forkhead box P3; Probable transcription factor. Plays a critical role in the control of immune response | signal transducer and activator of transcription 3 (acute-phase response factor); Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute- phase protein genes. Activated by IL31 through IL31RA. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity | 0.977 |
| FOXP3 | TBX21 | ENSP00000365380 | ENSP00000177694 | forkhead box P3; Probable transcription factor. Plays a critical role in the control of immune response | T-box 21; Transcription factor that controls the expression of the TH1 cytokine, interferon-gamma. Initiates TH1 lineage development from naive TH precursor cells both by activating TH1 genetic programs and by repressing the opposing TH2 programs | 0.895 |
| GZMB | BCL6 | ENSP00000216341 | ENSP00000232014 | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1); This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis | B-cell CLL/lymphoma 6; Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis | 0.874 |
| GZMB | FOXP3 | ENSP00000216341 | ENSP00000365380 | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1); This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis | forkhead box P3; Probable transcription factor. Plays a critical role in the control of immune response | 0.943 |
| GZMB | IL2 | ENSP00000216341 | ENSP00000226730 | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1); This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis | interleukin 2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells | 0.993 |
| GZMB | IL21 | ENSP00000216341 | ENSP00000264497 | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1); This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis | interleukin 21; Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation | 0.897 |
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