node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FGF2 | FGFR1 | ENSP00000264498 | ENSP00000393312 | fibroblast growth factor 2 (basic) | fibroblast growth factor receptor 1 | 0.999 |
FGF2 | FGFR2 | ENSP00000264498 | ENSP00000410294 | fibroblast growth factor 2 (basic) | fibroblast growth factor receptor 2 | 0.999 |
FGF2 | FGFR3 | ENSP00000264498 | ENSP00000339824 | fibroblast growth factor 2 (basic) | fibroblast growth factor receptor 3; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Required for normal development of the inner ear. Ph [...] | 0.999 |
FGF2 | FGFR4 | ENSP00000264498 | ENSP00000292408 | fibroblast growth factor 2 (basic) | fibroblast growth factor receptor 4; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of [...] | 0.999 |
FGF2 | GPC1 | ENSP00000264498 | ENSP00000264039 | fibroblast growth factor 2 (basic) | glypican 1; Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-med [...] | 0.995 |
FGF2 | HSPG2 | ENSP00000264498 | ENSP00000363827 | fibroblast growth factor 2 (basic) | heparan sulfate proteoglycan 2; Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development | 0.999 |
FGF2 | NANOG | ENSP00000264498 | ENSP00000229307 | fibroblast growth factor 2 (basic) | Nanog homeobox; Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5’-TAAT[GT][GT]-3’ or 5 [...] | 0.993 |
FGF2 | SDC1 | ENSP00000264498 | ENSP00000254351 | fibroblast growth factor 2 (basic) | syndecan 1; Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix | 0.996 |
FGF2 | SDC2 | ENSP00000264498 | ENSP00000307046 | fibroblast growth factor 2 (basic) | syndecan 2; Cell surface proteoglycan that bears heparan sulfate. Regulates dendritic arbor morphogenesis (By similarity) | 0.995 |
FGF2 | SDC4 | ENSP00000264498 | ENSP00000361818 | fibroblast growth factor 2 (basic) | syndecan 4; Cell surface proteoglycan that bears heparan sulfate | 0.996 |
FGFR1 | FGF2 | ENSP00000393312 | ENSP00000264498 | fibroblast growth factor receptor 1 | fibroblast growth factor 2 (basic) | 0.999 |
FGFR1 | GPC1 | ENSP00000393312 | ENSP00000264039 | fibroblast growth factor receptor 1 | glypican 1; Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-med [...] | 0.943 |
FGFR1 | HSPG2 | ENSP00000393312 | ENSP00000363827 | fibroblast growth factor receptor 1 | heparan sulfate proteoglycan 2; Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development | 0.635 |
FGFR1 | SDC1 | ENSP00000393312 | ENSP00000254351 | fibroblast growth factor receptor 1 | syndecan 1; Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix | 0.879 |
FGFR1 | SDC4 | ENSP00000393312 | ENSP00000361818 | fibroblast growth factor receptor 1 | syndecan 4; Cell surface proteoglycan that bears heparan sulfate | 0.943 |
FGFR2 | FGF2 | ENSP00000410294 | ENSP00000264498 | fibroblast growth factor receptor 2 | fibroblast growth factor 2 (basic) | 0.999 |
FGFR2 | FGFR3 | ENSP00000410294 | ENSP00000339824 | fibroblast growth factor receptor 2 | fibroblast growth factor receptor 3; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Required for normal development of the inner ear. Ph [...] | 0.600 |
FGFR3 | FGF2 | ENSP00000339824 | ENSP00000264498 | fibroblast growth factor receptor 3; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Required for normal development of the inner ear. Ph [...] | fibroblast growth factor 2 (basic) | 0.999 |
FGFR3 | FGFR2 | ENSP00000339824 | ENSP00000410294 | fibroblast growth factor receptor 3; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Required for normal development of the inner ear. Ph [...] | fibroblast growth factor receptor 2 | 0.600 |
FGFR3 | HSPG2 | ENSP00000339824 | ENSP00000363827 | fibroblast growth factor receptor 3; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Required for normal development of the inner ear. Ph [...] | heparan sulfate proteoglycan 2; Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development | 0.617 |