node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CNTF | CTF1 | ENSP00000355370 | ENSP00000279804 | ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy | cardiotrophin 1; Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor | 0.963 |
CNTF | IL11 | ENSP00000355370 | ENSP00000264563 | ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy | interleukin 11; Directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production | 0.937 |
CNTF | IL13RA1 | ENSP00000355370 | ENSP00000360730 | ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy | interleukin 13 receptor, alpha 1; Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity | 0.800 |
CNTF | IL6 | ENSP00000355370 | ENSP00000258743 | ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy | interleukin 6 (interferon, beta 2); Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig- secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and [...] | 0.988 |
CNTF | IL6ST | ENSP00000355370 | ENSP00000338799 | ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy | interleukin 6 signal transducer (gp130, oncostatin M receptor); Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development (By similarity). The type I OSM receptor is capable of transducing OSM-specific signaling events | 0.979 |
CNTF | LIFR | ENSP00000355370 | ENSP00000263409 | ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy | leukemia inhibitory factor receptor alpha; Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells | 0.996 |
CNTF | MPL | ENSP00000355370 | ENSP00000361548 | ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy | myeloproliferative leukemia virus oncogene; Receptor for thrombopoietin. May represent a regulatory molecule specific for TPO-R-dependent immune responses | 0.835 |
CNTF | OSM | ENSP00000355370 | ENSP00000215781 | ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy | oncostatin M; Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration (By similarity) | 0.963 |
CNTF | STAT3 | ENSP00000355370 | ENSP00000264657 | ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy | signal transducer and activator of transcription 3 (acute-phase response factor); Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute- phase protein genes. Activated by IL31 through IL31RA. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity | 0.942 |
CTF1 | CNTF | ENSP00000279804 | ENSP00000355370 | cardiotrophin 1; Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor | ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy | 0.963 |
CTF1 | IL11 | ENSP00000279804 | ENSP00000264563 | cardiotrophin 1; Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor | interleukin 11; Directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production | 0.942 |
CTF1 | IL13RA1 | ENSP00000279804 | ENSP00000360730 | cardiotrophin 1; Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor | interleukin 13 receptor, alpha 1; Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity | 0.800 |
CTF1 | IL6 | ENSP00000279804 | ENSP00000258743 | cardiotrophin 1; Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor | interleukin 6 (interferon, beta 2); Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig- secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and [...] | 0.989 |
CTF1 | IL6ST | ENSP00000279804 | ENSP00000338799 | cardiotrophin 1; Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor | interleukin 6 signal transducer (gp130, oncostatin M receptor); Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development (By similarity). The type I OSM receptor is capable of transducing OSM-specific signaling events | 0.946 |
CTF1 | LIFR | ENSP00000279804 | ENSP00000263409 | cardiotrophin 1; Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor | leukemia inhibitory factor receptor alpha; Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells | 0.996 |
CTF1 | MPL | ENSP00000279804 | ENSP00000361548 | cardiotrophin 1; Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor | myeloproliferative leukemia virus oncogene; Receptor for thrombopoietin. May represent a regulatory molecule specific for TPO-R-dependent immune responses | 0.817 |
CTF1 | OSM | ENSP00000279804 | ENSP00000215781 | cardiotrophin 1; Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor | oncostatin M; Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration (By similarity) | 0.967 |
CTF1 | STAT3 | ENSP00000279804 | ENSP00000264657 | cardiotrophin 1; Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor | signal transducer and activator of transcription 3 (acute-phase response factor); Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute- phase protein genes. Activated by IL31 through IL31RA. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity | 0.941 |
IL11 | CNTF | ENSP00000264563 | ENSP00000355370 | interleukin 11; Directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production | ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy | 0.937 |
IL11 | CTF1 | ENSP00000264563 | ENSP00000279804 | interleukin 11; Directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production | cardiotrophin 1; Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor | 0.942 |