node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGA | DOCK11 | ENSP00000264595 | ENSP00000276202 | aspartylglucosaminidase; Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins | dedicator of cytokinesis 11; Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP (By similarity) | 0.870 |
AGA | GAA | ENSP00000264595 | ENSP00000305692 | aspartylglucosaminidase; Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins | glucosidase, alpha; acid; Essential for the degradation of glygogen to glucose in lysosomes | 0.943 |
AGA | GGCT | ENSP00000264595 | ENSP00000275428 | aspartylglucosaminidase; Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins | gamma-glutamylcyclotransferase; Catalyzes the formation of 5-oxoproline from gamma- glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis | 0.883 |
AGA | GGT1 | ENSP00000264595 | ENSP00000248923 | aspartylglucosaminidase; Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins | gamma-glutamyltransferase 1; Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate. Isoform 3 seems to be inactive | 0.925 |
AGA | GGT2 | ENSP00000264595 | ENSP00000385721 | aspartylglucosaminidase; Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins | gamma-glutamyltransferase 2; Initiates extracellular glutathione (GSH) breakdown; catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors (By similarity) | 0.855 |
AGA | GLS | ENSP00000264595 | ENSP00000317379 | aspartylglucosaminidase; Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins | glutaminase; Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. Isoform 2 lacks catalytic activity | 0.870 |
AGA | PCYT1A | ENSP00000264595 | ENSP00000292823 | aspartylglucosaminidase; Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins | phosphate cytidylyltransferase 1, choline, alpha; Controls phosphatidylcholine synthesis | 0.824 |
AGA | QPCT | ENSP00000264595 | ENSP00000344829 | aspartylglucosaminidase; Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins | glutaminyl-peptide cyclotransferase; Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-beta-amyloid. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides | 0.892 |
AGA | TGM2 | ENSP00000264595 | ENSP00000355330 | aspartylglucosaminidase; Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins | transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase); Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins | 0.842 |
AGA | TSHZ1 | ENSP00000264595 | ENSP00000323584 | aspartylglucosaminidase; Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins | teashirt zinc finger homeobox 1; Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential) | 0.875 |
DOCK11 | AGA | ENSP00000276202 | ENSP00000264595 | dedicator of cytokinesis 11; Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP (By similarity) | aspartylglucosaminidase; Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins | 0.870 |
DOCK11 | GAA | ENSP00000276202 | ENSP00000305692 | dedicator of cytokinesis 11; Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP (By similarity) | glucosidase, alpha; acid; Essential for the degradation of glygogen to glucose in lysosomes | 0.870 |
DOCK11 | GGCT | ENSP00000276202 | ENSP00000275428 | dedicator of cytokinesis 11; Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP (By similarity) | gamma-glutamylcyclotransferase; Catalyzes the formation of 5-oxoproline from gamma- glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis | 0.824 |
DOCK11 | GGT1 | ENSP00000276202 | ENSP00000248923 | dedicator of cytokinesis 11; Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP (By similarity) | gamma-glutamyltransferase 1; Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate. Isoform 3 seems to be inactive | 0.813 |
DOCK11 | GGT2 | ENSP00000276202 | ENSP00000385721 | dedicator of cytokinesis 11; Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP (By similarity) | gamma-glutamyltransferase 2; Initiates extracellular glutathione (GSH) breakdown; catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors (By similarity) | 0.568 |
DOCK11 | GLS | ENSP00000276202 | ENSP00000317379 | dedicator of cytokinesis 11; Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP (By similarity) | glutaminase; Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. Isoform 2 lacks catalytic activity | 0.815 |
DOCK11 | PCYT1A | ENSP00000276202 | ENSP00000292823 | dedicator of cytokinesis 11; Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP (By similarity) | phosphate cytidylyltransferase 1, choline, alpha; Controls phosphatidylcholine synthesis | 0.813 |
DOCK11 | QPCT | ENSP00000276202 | ENSP00000344829 | dedicator of cytokinesis 11; Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP (By similarity) | glutaminyl-peptide cyclotransferase; Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-beta-amyloid. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides | 0.824 |
DOCK11 | TGM2 | ENSP00000276202 | ENSP00000355330 | dedicator of cytokinesis 11; Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP (By similarity) | transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase); Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins | 0.725 |
DOCK11 | TSHZ1 | ENSP00000276202 | ENSP00000323584 | dedicator of cytokinesis 11; Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP (By similarity) | teashirt zinc finger homeobox 1; Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential) | 0.824 |