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KCNA1 KCNA1 KCNA2 KCNA2 RHOA RHOA SRC SRC NFASC NFASC CNTNAP1 CNTNAP1 RASA1 RASA1 CNTN1 CNTN1 NRCAM NRCAM CNTN2 CNTN2 EPB41L3 EPB41L3
"CNTNAP1" - contactin associated protein 1 in Homo sapiens
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protein of unknown 3D structure
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CNTNAP1contactin associated protein 1; Seems to play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the paranodal region of the axo-glial junction. In association with contactin may have a role in the signaling between axons and myelinating glial cells (1384 aa)    
Predicted Functional Partners:
NFASC
neurofascin (1240 aa)
      score_image score_image score_image score_image   0.995
CNTN1
contactin 1; Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurit [...] (1018 aa)
      score_image   score_image score_image   0.987
KCNA1
potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia); Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient (495 aa)
        score_image   score_image   0.961
SRC
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian); Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein- coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to f [...] (536 aa)
      score_image score_image   score_image   0.941
RASA1
RAS p21 protein activator (GTPase activating protein) 1; Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21; this stimulation may be further increased in the presence of NCK1 (1047 aa)
            score_image   0.877
RHOA
ras homolog family member A; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disor [...] (193 aa)
        score_image   score_image   0.867
EPB41L3
erythrocyte membrane protein band 4.1-like 3; Critical growth regulator in the pathogenesis of meningiomas (1087 aa)
            score_image   0.862
NRCAM
neuronal cell adhesion molecule; Cell adhesion, ankyrin-binding protein involved in neuron-neuron adhesion. May play a role in the molecular assembly of the nodes of Ranvier (By similarity) (1304 aa)
      score_image     score_image   0.852
KCNA2
potassium voltage-gated channel, shaker-related subfamily, member 2; Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient (499 aa)
        score_image   score_image   0.848
CNTN2
contactin 2 (axonal); May play a role in the initial growth and guidance of axons. May be involved in cell adhesion (1040 aa)
      score_image     score_image   0.811
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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