RAPGEFL1 protein (Homo sapiens) - STRING network view

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RAPGEFL1

Rap guanine nucleotide exchange factor (GEF)-like 1; Probable guanine nucleotide exchange factor (GEF) (456 aa)

Predicted Functional Partners:

ADCY1

0.631

MAP3K8

0.611

RGL4

0.576

ZFAT

0.484

NPPA

0.454

SDHB

0.400

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY1	MAP3K8	ENSP00000297323	ENSP00000263056	adenylate cyclase 1 (brain); This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning	mitogen-activated protein kinase kinase kinase 8; Required for TLR4 activation of the MEK/ERK pathway. Able to activate NF-kappa-B 1 by stimulating proteasome-mediated proteolysis of NF-kappa-B 1/p105. Plays a role in the cell cycle. The longer form has some transforming activity, although it is much weaker than the activated cot oncoprotein	0.547
ADCY1	RAPGEFL1	ENSP00000297323	ENSP00000264644	adenylate cyclase 1 (brain); This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning	Rap guanine nucleotide exchange factor (GEF)-like 1; Probable guanine nucleotide exchange factor (GEF)	0.631
MAP3K8	ADCY1	ENSP00000263056	ENSP00000297323	mitogen-activated protein kinase kinase kinase 8; Required for TLR4 activation of the MEK/ERK pathway. Able to activate NF-kappa-B 1 by stimulating proteasome-mediated proteolysis of NF-kappa-B 1/p105. Plays a role in the cell cycle. The longer form has some transforming activity, although it is much weaker than the activated cot oncoprotein	adenylate cyclase 1 (brain); This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning	0.547
MAP3K8	RAPGEFL1	ENSP00000263056	ENSP00000264644	mitogen-activated protein kinase kinase kinase 8; Required for TLR4 activation of the MEK/ERK pathway. Able to activate NF-kappa-B 1 by stimulating proteasome-mediated proteolysis of NF-kappa-B 1/p105. Plays a role in the cell cycle. The longer form has some transforming activity, although it is much weaker than the activated cot oncoprotein	Rap guanine nucleotide exchange factor (GEF)-like 1; Probable guanine nucleotide exchange factor (GEF)	0.611
MAP3K8	ZFAT	ENSP00000263056	ENSP00000367069	mitogen-activated protein kinase kinase kinase 8; Required for TLR4 activation of the MEK/ERK pathway. Able to activate NF-kappa-B 1 by stimulating proteasome-mediated proteolysis of NF-kappa-B 1/p105. Plays a role in the cell cycle. The longer form has some transforming activity, although it is much weaker than the activated cot oncoprotein	zinc finger and AT hook domain containing	0.432
NPPA	RAPGEFL1	ENSP00000365663	ENSP00000264644	natriuretic peptide A; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3	Rap guanine nucleotide exchange factor (GEF)-like 1; Probable guanine nucleotide exchange factor (GEF)	0.454
RAPGEFL1	ADCY1	ENSP00000264644	ENSP00000297323	Rap guanine nucleotide exchange factor (GEF)-like 1; Probable guanine nucleotide exchange factor (GEF)	adenylate cyclase 1 (brain); This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning	0.631
RAPGEFL1	MAP3K8	ENSP00000264644	ENSP00000263056	Rap guanine nucleotide exchange factor (GEF)-like 1; Probable guanine nucleotide exchange factor (GEF)	mitogen-activated protein kinase kinase kinase 8; Required for TLR4 activation of the MEK/ERK pathway. Able to activate NF-kappa-B 1 by stimulating proteasome-mediated proteolysis of NF-kappa-B 1/p105. Plays a role in the cell cycle. The longer form has some transforming activity, although it is much weaker than the activated cot oncoprotein	0.611
RAPGEFL1	NPPA	ENSP00000264644	ENSP00000365663	Rap guanine nucleotide exchange factor (GEF)-like 1; Probable guanine nucleotide exchange factor (GEF)	natriuretic peptide A; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3	0.454
RAPGEFL1	RGL4	ENSP00000264644	ENSP00000290691	Rap guanine nucleotide exchange factor (GEF)-like 1; Probable guanine nucleotide exchange factor (GEF)	ral guanine nucleotide dissociation stimulator-like 4	0.576
RAPGEFL1	SDHB	ENSP00000264644	ENSP00000364649	Rap guanine nucleotide exchange factor (GEF)-like 1; Probable guanine nucleotide exchange factor (GEF)	succinate dehydrogenase complex, subunit B, iron sulfur (Ip); Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q)	0.400
RAPGEFL1	ZFAT	ENSP00000264644	ENSP00000367069	Rap guanine nucleotide exchange factor (GEF)-like 1; Probable guanine nucleotide exchange factor (GEF)	zinc finger and AT hook domain containing	0.484
RGL4	RAPGEFL1	ENSP00000290691	ENSP00000264644	ral guanine nucleotide dissociation stimulator-like 4	Rap guanine nucleotide exchange factor (GEF)-like 1; Probable guanine nucleotide exchange factor (GEF)	0.576
SDHB	RAPGEFL1	ENSP00000364649	ENSP00000264644	succinate dehydrogenase complex, subunit B, iron sulfur (Ip); Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q)	Rap guanine nucleotide exchange factor (GEF)-like 1; Probable guanine nucleotide exchange factor (GEF)	0.400
ZFAT	MAP3K8	ENSP00000367069	ENSP00000263056	zinc finger and AT hook domain containing	mitogen-activated protein kinase kinase kinase 8; Required for TLR4 activation of the MEK/ERK pathway. Able to activate NF-kappa-B 1 by stimulating proteasome-mediated proteolysis of NF-kappa-B 1/p105. Plays a role in the cell cycle. The longer form has some transforming activity, although it is much weaker than the activated cot oncoprotein	0.432
ZFAT	RAPGEFL1	ENSP00000367069	ENSP00000264644	zinc finger and AT hook domain containing	Rap guanine nucleotide exchange factor (GEF)-like 1; Probable guanine nucleotide exchange factor (GEF)	0.484

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