UFSP2 protein (Homo sapiens) - STRING network view

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UFSP2

UFM1-specific peptidase 2; Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, an ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins (By similarity) (469 aa)

Predicted Functional Partners:

UFM1

0.896

DDRGK1

0.856

UFL1

0.850

UFC1

0.824

UBA5

0.796

URM1

0.648

ALKBH1

0.624

C4orf27

0.586

FAM110B

0.581

SPEF2

0.580

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALKBH1	UFSP2	ENSP00000216489	ENSP00000264689	alkB, alkylation repair homolog 1 (E. coli); Dioxygenase that repairs alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative demethylation. Requires molecular oxygen, alpha-ketoglutarate and iron. May have a role in placental trophoblast lineage differentiation (By similarity). Has DNA lyase activity and introduces double-stranded breaks at abasic sites. Cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites. DNA lyase activity does not require alpha-ketoglutarate and iron	UFM1-specific peptidase 2; Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, an ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins (By similarity)	0.624
C4orf27	FAM110B	ENSP00000406598	ENSP00000355204	chromosome 4 open reading frame 27	family with sequence similarity 110, member B; May be involved in tumor progression	0.583
C4orf27	SPEF2	ENSP00000406598	ENSP00000348314	chromosome 4 open reading frame 27	sperm flagellar 2; Required for correct axoneme development (By similarity)	0.579
C4orf27	UFSP2	ENSP00000406598	ENSP00000264689	chromosome 4 open reading frame 27	UFM1-specific peptidase 2; Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, an ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins (By similarity)	0.586
DDRGK1	UBA5	ENSP00000346483	ENSP00000348565	DDRGK domain containing 1	ubiquitin-like modifier activating enzyme 5; E1-like enzyme which activates UFM1 and SUMO2	0.729
DDRGK1	UFC1	ENSP00000346483	ENSP00000356982	DDRGK domain containing 1	ubiquitin-fold modifier conjugating enzyme 1; E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage	0.722
DDRGK1	UFL1	ENSP00000346483	ENSP00000358283	DDRGK domain containing 1	UFM1-specific ligase 1; E3 UFM1-protein ligase that mediates ufmylation of target proteins such as DDRGK1/C20orf116. The function of ufmylation is unknown. May act as a tumor suppressor by inhibiting cell invasion, blocking NF-kappa-B signaling and increasing stability of CDK5RAP3	0.990
DDRGK1	UFM1	ENSP00000346483	ENSP00000239878	DDRGK domain containing 1	ubiquitin-fold modifier 1; Ubiquitin-like modifier protein which binds to a number of target proteins, such as DDRGK1	0.952
DDRGK1	UFSP2	ENSP00000346483	ENSP00000264689	DDRGK domain containing 1	UFM1-specific peptidase 2; Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, an ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins (By similarity)	0.856
DDRGK1	URM1	ENSP00000346483	ENSP00000412922	DDRGK domain containing 1	ubiquitin related modifier 1; Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. May also act as an ubiquitin-like protein that is covalently conjugated to other proteins; the relevance of such function is however unclear in vivo	0.684
FAM110B	C4orf27	ENSP00000355204	ENSP00000406598	family with sequence similarity 110, member B; May be involved in tumor progression	chromosome 4 open reading frame 27	0.583
FAM110B	SPEF2	ENSP00000355204	ENSP00000348314	family with sequence similarity 110, member B; May be involved in tumor progression	sperm flagellar 2; Required for correct axoneme development (By similarity)	0.580
FAM110B	UFSP2	ENSP00000355204	ENSP00000264689	family with sequence similarity 110, member B; May be involved in tumor progression	UFM1-specific peptidase 2; Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, an ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins (By similarity)	0.581
SPEF2	C4orf27	ENSP00000348314	ENSP00000406598	sperm flagellar 2; Required for correct axoneme development (By similarity)	chromosome 4 open reading frame 27	0.579
SPEF2	FAM110B	ENSP00000348314	ENSP00000355204	sperm flagellar 2; Required for correct axoneme development (By similarity)	family with sequence similarity 110, member B; May be involved in tumor progression	0.580
SPEF2	UFSP2	ENSP00000348314	ENSP00000264689	sperm flagellar 2; Required for correct axoneme development (By similarity)	UFM1-specific peptidase 2; Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, an ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins (By similarity)	0.580
UBA5	DDRGK1	ENSP00000348565	ENSP00000346483	ubiquitin-like modifier activating enzyme 5; E1-like enzyme which activates UFM1 and SUMO2	DDRGK domain containing 1	0.729
UBA5	UFC1	ENSP00000348565	ENSP00000356982	ubiquitin-like modifier activating enzyme 5; E1-like enzyme which activates UFM1 and SUMO2	ubiquitin-fold modifier conjugating enzyme 1; E2-like enzyme which forms an intermediate with UFM1 via a thioester linkage	0.934
UBA5	UFL1	ENSP00000348565	ENSP00000358283	ubiquitin-like modifier activating enzyme 5; E1-like enzyme which activates UFM1 and SUMO2	UFM1-specific ligase 1; E3 UFM1-protein ligase that mediates ufmylation of target proteins such as DDRGK1/C20orf116. The function of ufmylation is unknown. May act as a tumor suppressor by inhibiting cell invasion, blocking NF-kappa-B signaling and increasing stability of CDK5RAP3	0.795
UBA5	UFM1	ENSP00000348565	ENSP00000239878	ubiquitin-like modifier activating enzyme 5; E1-like enzyme which activates UFM1 and SUMO2	ubiquitin-fold modifier 1; Ubiquitin-like modifier protein which binds to a number of target proteins, such as DDRGK1	0.993

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