node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CRH | CYP17A1 | ENSP00000276571 | ENSP00000358903 | corticotropin releasing hormone; This hormone from hypothalamus regulates the release of corticotropin from pituitary gland | cytochrome P450, family 17, subfamily A, polypeptide 1; Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty | 0.504 |
CRH | MC1R | ENSP00000276571 | ENSP00000451605 | corticotropin releasing hormone; This hormone from hypothalamus regulates the release of corticotropin from pituitary gland | melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) | 0.943 |
CRH | MC2R | ENSP00000276571 | ENSP00000333821 | corticotropin releasing hormone; This hormone from hypothalamus regulates the release of corticotropin from pituitary gland | melanocortin 2 receptor (adrenocorticotropic hormone); Receptor for ACTH. This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase | 0.990 |
CRH | MC3R | ENSP00000276571 | ENSP00000243911 | corticotropin releasing hormone; This hormone from hypothalamus regulates the release of corticotropin from pituitary gland | melanocortin 3 receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase | 0.948 |
CRH | MC4R | ENSP00000276571 | ENSP00000299766 | corticotropin releasing hormone; This hormone from hypothalamus regulates the release of corticotropin from pituitary gland | melanocortin 4 receptor; Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. This receptor is mediated by G proteins that stimulate adenylate cyclase | 0.992 |
CRH | MC5R | ENSP00000276571 | ENSP00000318077 | corticotropin releasing hormone; This hormone from hypothalamus regulates the release of corticotropin from pituitary gland | melanocortin 5 receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins | 0.936 |
CRH | NPY | ENSP00000276571 | ENSP00000242152 | corticotropin releasing hormone; This hormone from hypothalamus regulates the release of corticotropin from pituitary gland | neuropeptide Y; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone | 0.972 |
CRH | NR4A1 | ENSP00000276571 | ENSP00000353427 | corticotropin releasing hormone; This hormone from hypothalamus regulates the release of corticotropin from pituitary gland | nuclear receptor subfamily 4, group A, member 1; Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5’- AAAAGGTCA-3’ (By similarity). May inhibit NF-kappa-B transactivation of IL2 | 0.909 |
CRH | PDYN | ENSP00000276571 | ENSP00000217305 | corticotropin releasing hormone; This hormone from hypothalamus regulates the release of corticotropin from pituitary gland | prodynorphin; Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity) | 0.700 |
CRH | POMC | ENSP00000276571 | ENSP00000264708 | corticotropin releasing hormone; This hormone from hypothalamus regulates the release of corticotropin from pituitary gland | proopiomelanocortin; ACTH stimulates the adrenal glands to release cortisol | 0.998 |
CYP17A1 | CRH | ENSP00000358903 | ENSP00000276571 | cytochrome P450, family 17, subfamily A, polypeptide 1; Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty | corticotropin releasing hormone; This hormone from hypothalamus regulates the release of corticotropin from pituitary gland | 0.504 |
CYP17A1 | MC2R | ENSP00000358903 | ENSP00000333821 | cytochrome P450, family 17, subfamily A, polypeptide 1; Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty | melanocortin 2 receptor (adrenocorticotropic hormone); Receptor for ACTH. This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase | 0.674 |
CYP17A1 | NR4A1 | ENSP00000358903 | ENSP00000353427 | cytochrome P450, family 17, subfamily A, polypeptide 1; Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty | nuclear receptor subfamily 4, group A, member 1; Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5’- AAAAGGTCA-3’ (By similarity). May inhibit NF-kappa-B transactivation of IL2 | 0.591 |
CYP17A1 | POMC | ENSP00000358903 | ENSP00000264708 | cytochrome P450, family 17, subfamily A, polypeptide 1; Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty | proopiomelanocortin; ACTH stimulates the adrenal glands to release cortisol | 0.994 |
MC1R | CRH | ENSP00000451605 | ENSP00000276571 | melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) | corticotropin releasing hormone; This hormone from hypothalamus regulates the release of corticotropin from pituitary gland | 0.943 |
MC1R | MC2R | ENSP00000451605 | ENSP00000333821 | melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) | melanocortin 2 receptor (adrenocorticotropic hormone); Receptor for ACTH. This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase | 0.907 |
MC1R | MC3R | ENSP00000451605 | ENSP00000243911 | melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) | melanocortin 3 receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase | 0.905 |
MC1R | MC4R | ENSP00000451605 | ENSP00000299766 | melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) | melanocortin 4 receptor; Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. This receptor is mediated by G proteins that stimulate adenylate cyclase | 0.957 |
MC1R | MC5R | ENSP00000451605 | ENSP00000318077 | melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) | melanocortin 5 receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins | 0.905 |
MC1R | NPY | ENSP00000451605 | ENSP00000242152 | melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) | neuropeptide Y; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone | 0.416 |