DNAJC27 protein (Homo sapiens) - STRING network view

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DNAJC27

DnaJ (Hsp40) homolog, subfamily C, member 27 (273 aa)

Predicted Functional Partners:

AGFG1

0.662

BRAF

0.628

ACLY

0.621

FGF19

0.621

RABL6

0.608

MBIP

0.573

PHLPP2

0.539

PHLPP1

0.539

POC5

0.534

DNAJC15

0.527

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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... protein annotations:

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a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACLY	DNAJC27	ENSP00000253792	ENSP00000264711	ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine	DnaJ (Hsp40) homolog, subfamily C, member 27	0.621
AGFG1	DNAJC27	ENSP00000387282	ENSP00000264711	ArfGAP with FG repeats 1	DnaJ (Hsp40) homolog, subfamily C, member 27	0.662
AGFG1	RABL6	ENSP00000387282	ENSP00000360727	ArfGAP with FG repeats 1	RAB, member RAS oncogene family-like 6	0.610
BRAF	DNAJC27	ENSP00000288602	ENSP00000264711	v-raf murine sarcoma viral oncogene homolog B1	DnaJ (Hsp40) homolog, subfamily C, member 27	0.628
DNAJC15	DNAJC27	ENSP00000368523	ENSP00000264711	DnaJ (Hsp40) homolog, subfamily C, member 15	DnaJ (Hsp40) homolog, subfamily C, member 27	0.527
DNAJC27	ACLY	ENSP00000264711	ENSP00000253792	DnaJ (Hsp40) homolog, subfamily C, member 27	ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine	0.621
DNAJC27	AGFG1	ENSP00000264711	ENSP00000387282	DnaJ (Hsp40) homolog, subfamily C, member 27	ArfGAP with FG repeats 1	0.662
DNAJC27	BRAF	ENSP00000264711	ENSP00000288602	DnaJ (Hsp40) homolog, subfamily C, member 27	v-raf murine sarcoma viral oncogene homolog B1	0.628
DNAJC27	DNAJC15	ENSP00000264711	ENSP00000368523	DnaJ (Hsp40) homolog, subfamily C, member 27	DnaJ (Hsp40) homolog, subfamily C, member 15	0.527
DNAJC27	FGF19	ENSP00000264711	ENSP00000294312	DnaJ (Hsp40) homolog, subfamily C, member 27	fibroblast growth factor 19; Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4	0.621
DNAJC27	MBIP	ENSP00000264711	ENSP00000399718	DnaJ (Hsp40) homolog, subfamily C, member 27	MAP3K12 binding inhibitory protein 1; Inhibits the MAP3K12 activity to induce the activation of the JNK/SAPK pathway. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4	0.573
DNAJC27	PHLPP1	ENSP00000264711	ENSP00000262719	DnaJ (Hsp40) homolog, subfamily C, member 27	PH domain and leucine rich repeat protein phosphatase 1; Protein phosphatase that mediates dephosphorylation of ’Ser-473’ of AKT1, ’Ser-660’ of PRKCB isoform beta-II and ’Ser- 657’ of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of ’Ser-473’ of AKT1 triggers apoptosis and suppression of tumor growth. Controls the phosphorylation of AKT2 and AKT3 more efficiently than that of AKT1. Dephosphorylation of PRKCA and PRKCB leads [...]	0.539
DNAJC27	PHLPP2	ENSP00000264711	ENSP00000348611	DnaJ (Hsp40) homolog, subfamily C, member 27	PH domain and leucine rich repeat protein phosphatase 2; Protein phosphatase that mediates dephosphorylation of ’Ser-473’ of AKT1, ’Ser-660’ of PRKCB isoform beta-II and ’Ser- 657’ of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of ’Ser-473’ of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradati [...]	0.539
DNAJC27	POC5	ENSP00000264711	ENSP00000410216	DnaJ (Hsp40) homolog, subfamily C, member 27	POC5 centriolar protein homolog (Chlamydomonas); Essential for the assembly of the distal half of centrioles, required for centriole elongation	0.534
DNAJC27	RABL6	ENSP00000264711	ENSP00000360727	DnaJ (Hsp40) homolog, subfamily C, member 27	RAB, member RAS oncogene family-like 6	0.608
FGF19	DNAJC27	ENSP00000294312	ENSP00000264711	fibroblast growth factor 19; Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4	DnaJ (Hsp40) homolog, subfamily C, member 27	0.621
MBIP	DNAJC27	ENSP00000399718	ENSP00000264711	MAP3K12 binding inhibitory protein 1; Inhibits the MAP3K12 activity to induce the activation of the JNK/SAPK pathway. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4	DnaJ (Hsp40) homolog, subfamily C, member 27	0.573
PHLPP1	DNAJC27	ENSP00000262719	ENSP00000264711	PH domain and leucine rich repeat protein phosphatase 1; Protein phosphatase that mediates dephosphorylation of ’Ser-473’ of AKT1, ’Ser-660’ of PRKCB isoform beta-II and ’Ser- 657’ of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of ’Ser-473’ of AKT1 triggers apoptosis and suppression of tumor growth. Controls the phosphorylation of AKT2 and AKT3 more efficiently than that of AKT1. Dephosphorylation of PRKCA and PRKCB leads [...]	DnaJ (Hsp40) homolog, subfamily C, member 27	0.539
PHLPP1	PHLPP2	ENSP00000262719	ENSP00000348611	PH domain and leucine rich repeat protein phosphatase 1; Protein phosphatase that mediates dephosphorylation of ’Ser-473’ of AKT1, ’Ser-660’ of PRKCB isoform beta-II and ’Ser- 657’ of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of ’Ser-473’ of AKT1 triggers apoptosis and suppression of tumor growth. Controls the phosphorylation of AKT2 and AKT3 more efficiently than that of AKT1. Dephosphorylation of PRKCA and PRKCB leads [...]	PH domain and leucine rich repeat protein phosphatase 2; Protein phosphatase that mediates dephosphorylation of ’Ser-473’ of AKT1, ’Ser-660’ of PRKCB isoform beta-II and ’Ser- 657’ of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of ’Ser-473’ of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradati [...]	0.999
PHLPP2	DNAJC27	ENSP00000348611	ENSP00000264711	PH domain and leucine rich repeat protein phosphatase 2; Protein phosphatase that mediates dephosphorylation of ’Ser-473’ of AKT1, ’Ser-660’ of PRKCB isoform beta-II and ’Ser- 657’ of PRKCA. AKT1 regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of ’Ser-473’ of AKT1 triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradati [...]	DnaJ (Hsp40) homolog, subfamily C, member 27	0.539

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