node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADD1 | ADD2 | ENSP00000264758 | ENSP00000264436 | adducin 1 (alpha) | adducin 2 (beta) | 0.888 |
ADD1 | CALM1 | ENSP00000264758 | ENSP00000349467 | adducin 1 (alpha) | calmodulin 1 (phosphorylase kinase, delta) | 0.812 |
ADD1 | CAPZB | ENSP00000264758 | ENSP00000264202 | adducin 1 (alpha) | capping protein (actin filament) muscle Z-line, beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization | 0.734 |
ADD1 | CASP3 | ENSP00000264758 | ENSP00000311032 | adducin 1 (alpha) | caspase 3, apoptosis-related cysteine peptidase; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a ’216-Asp-|-Gly-217’ bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage | 0.955 |
ADD1 | CDC42BPB | ENSP00000264758 | ENSP00000355237 | adducin 1 (alpha) | CDC42 binding protein kinase beta (DMPK-like); Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates PPP1R12A | 0.737 |
ADD1 | PRKCD | ENSP00000264758 | ENSP00000331602 | adducin 1 (alpha) | protein kinase C, delta; Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor- initiated cell death, is involved in tumor suppression as well as survival of several cancers, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses. Upon DNA damage, activates t [...] | 0.816 |
ADD1 | RHOA | ENSP00000264758 | ENSP00000400175 | adducin 1 (alpha) | ras homolog family member A; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disor [...] | 0.751 |
ADD1 | RHOB | ENSP00000264758 | ENSP00000272233 | adducin 1 (alpha) | ras homolog family member B; Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular develo [...] | 0.735 |
ADD1 | RHOC | ENSP00000264758 | ENSP00000285735 | adducin 1 (alpha) | ras homolog family member C; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells | 0.734 |
ADD1 | SPTA1 | ENSP00000264758 | ENSP00000357130 | adducin 1 (alpha) | spectrin, alpha, erythrocytic 1 (elliptocytosis 2); Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane | 0.878 |
ADD2 | ADD1 | ENSP00000264436 | ENSP00000264758 | adducin 2 (beta) | adducin 1 (alpha) | 0.888 |
ADD2 | CALM1 | ENSP00000264436 | ENSP00000349467 | adducin 2 (beta) | calmodulin 1 (phosphorylase kinase, delta) | 0.578 |
ADD2 | CAPZB | ENSP00000264436 | ENSP00000264202 | adducin 2 (beta) | capping protein (actin filament) muscle Z-line, beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization | 0.737 |
ADD2 | CDC42BPB | ENSP00000264436 | ENSP00000355237 | adducin 2 (beta) | CDC42 binding protein kinase beta (DMPK-like); Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates PPP1R12A | 0.737 |
ADD2 | PRKCD | ENSP00000264436 | ENSP00000331602 | adducin 2 (beta) | protein kinase C, delta; Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor- initiated cell death, is involved in tumor suppression as well as survival of several cancers, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses. Upon DNA damage, activates t [...] | 0.813 |
ADD2 | RHOA | ENSP00000264436 | ENSP00000400175 | adducin 2 (beta) | ras homolog family member A; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disor [...] | 0.734 |
ADD2 | RHOB | ENSP00000264436 | ENSP00000272233 | adducin 2 (beta) | ras homolog family member B; Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular develo [...] | 0.734 |
ADD2 | RHOC | ENSP00000264436 | ENSP00000285735 | adducin 2 (beta) | ras homolog family member C; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells | 0.734 |
ADD2 | SPTA1 | ENSP00000264436 | ENSP00000357130 | adducin 2 (beta) | spectrin, alpha, erythrocytic 1 (elliptocytosis 2); Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane | 0.486 |
CALM1 | ADD1 | ENSP00000349467 | ENSP00000264758 | calmodulin 1 (phosphorylase kinase, delta) | adducin 1 (alpha) | 0.812 |