| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C20orf195 | GPBP1 | ENSP00000359115 | ENSP00000264779 | chromosome 20 open reading frame 195 | GC-rich promoter binding protein 1; Functions as a GC-rich promoter-specific transactivating transcription factor (By similarity) | 0.554 |
| EP300 | GPBP1 | ENSP00000263253 | ENSP00000264779 | E1A binding protein p300; Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Also functions as acetyltransferase for nonhistone targets. Acetylates ’Lys-131’ of ALX1 and acts as its coactivator in the presence of CREBBP. Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of TP53 through acetylation and [...] | GC-rich promoter binding protein 1; Functions as a GC-rich promoter-specific transactivating transcription factor (By similarity) | 0.726 |
| EP300 | GTF2B | ENSP00000263253 | ENSP00000359531 | E1A binding protein p300; Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Also functions as acetyltransferase for nonhistone targets. Acetylates ’Lys-131’ of ALX1 and acts as its coactivator in the presence of CREBBP. Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of TP53 through acetylation and [...] | general transcription factor IIB; General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II | 0.967 |
| FKBP8 | GPBP1 | ENSP00000222308 | ENSP00000264779 | FK506 binding protein 8, 38kDa; Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis | GC-rich promoter binding protein 1; Functions as a GC-rich promoter-specific transactivating transcription factor (By similarity) | 0.434 |
| GPBP1 | C20orf195 | ENSP00000264779 | ENSP00000359115 | GC-rich promoter binding protein 1; Functions as a GC-rich promoter-specific transactivating transcription factor (By similarity) | chromosome 20 open reading frame 195 | 0.554 |
| GPBP1 | EP300 | ENSP00000264779 | ENSP00000263253 | GC-rich promoter binding protein 1; Functions as a GC-rich promoter-specific transactivating transcription factor (By similarity) | E1A binding protein p300; Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Also functions as acetyltransferase for nonhistone targets. Acetylates ’Lys-131’ of ALX1 and acts as its coactivator in the presence of CREBBP. Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of TP53 through acetylation and [...] | 0.726 |
| GPBP1 | FKBP8 | ENSP00000264779 | ENSP00000222308 | GC-rich promoter binding protein 1; Functions as a GC-rich promoter-specific transactivating transcription factor (By similarity) | FK506 binding protein 8, 38kDa; Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis | 0.434 |
| GPBP1 | GTF2B | ENSP00000264779 | ENSP00000359531 | GC-rich promoter binding protein 1; Functions as a GC-rich promoter-specific transactivating transcription factor (By similarity) | general transcription factor IIB; General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II | 0.635 |
| GPBP1 | NUDT18 | ENSP00000264779 | ENSP00000307852 | GC-rich promoter binding protein 1; Functions as a GC-rich promoter-specific transactivating transcription factor (By similarity) | nudix (nucleoside diphosphate linked moiety X)-type motif 18; Mediates the hydrolyzis of oxidized nucleoside diphosphate derivatives. Hydrolyzes 8-oxo-7,8-dihydroguanine (8- oxo-Gua)-containing deoxyribo- and ribonucleoside diphosphates to the monophosphates. Hydrolyzes 8-oxo-dGDP and 8-oxo-GDP with the same efficiencies. Hydrolyzes also 8-OH-dADP and 2-OH-dADP. Exhibited no or minimal hydrolyzis activity against 8-oxo-dGTP, 8- oxo-GTP, dGTP, GTP, dGDP and GDP. Probably removes oxidized guanine nucleotides from both the DNA and RNA precursor pools | 0.587 |
| GPBP1 | PLEKHF2 | ENSP00000264779 | ENSP00000322373 | GC-rich promoter binding protein 1; Functions as a GC-rich promoter-specific transactivating transcription factor (By similarity) | pleckstrin homology domain containing, family F (with FYVE domain) member 2 | 0.461 |
| GPBP1 | SAP130 | ENSP00000264779 | ENSP00000350333 | GC-rich promoter binding protein 1; Functions as a GC-rich promoter-specific transactivating transcription factor (By similarity) | Sin3A-associated protein, 130kDa; Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes | 0.538 |
| GPBP1 | TMEM134 | ENSP00000264779 | ENSP00000312615 | GC-rich promoter binding protein 1; Functions as a GC-rich promoter-specific transactivating transcription factor (By similarity) | transmembrane protein 134 | 0.451 |
| GPBP1 | TMEM139 | ENSP00000264779 | ENSP00000352284 | GC-rich promoter binding protein 1; Functions as a GC-rich promoter-specific transactivating transcription factor (By similarity) | transmembrane protein 139 | 0.422 |
| GPBP1 | TOP2A | ENSP00000264779 | ENSP00000411532 | GC-rich promoter binding protein 1; Functions as a GC-rich promoter-specific transactivating transcription factor (By similarity) | topoisomerase (DNA) II alpha 170kDa | 0.748 |
| GTF2B | EP300 | ENSP00000359531 | ENSP00000263253 | general transcription factor IIB; General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II | E1A binding protein p300; Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Also functions as acetyltransferase for nonhistone targets. Acetylates ’Lys-131’ of ALX1 and acts as its coactivator in the presence of CREBBP. Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of TP53 through acetylation and [...] | 0.967 |
| GTF2B | GPBP1 | ENSP00000359531 | ENSP00000264779 | general transcription factor IIB; General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II | GC-rich promoter binding protein 1; Functions as a GC-rich promoter-specific transactivating transcription factor (By similarity) | 0.635 |
| NUDT18 | GPBP1 | ENSP00000307852 | ENSP00000264779 | nudix (nucleoside diphosphate linked moiety X)-type motif 18; Mediates the hydrolyzis of oxidized nucleoside diphosphate derivatives. Hydrolyzes 8-oxo-7,8-dihydroguanine (8- oxo-Gua)-containing deoxyribo- and ribonucleoside diphosphates to the monophosphates. Hydrolyzes 8-oxo-dGDP and 8-oxo-GDP with the same efficiencies. Hydrolyzes also 8-OH-dADP and 2-OH-dADP. Exhibited no or minimal hydrolyzis activity against 8-oxo-dGTP, 8- oxo-GTP, dGTP, GTP, dGDP and GDP. Probably removes oxidized guanine nucleotides from both the DNA and RNA precursor pools | GC-rich promoter binding protein 1; Functions as a GC-rich promoter-specific transactivating transcription factor (By similarity) | 0.587 |
| PLEKHF2 | GPBP1 | ENSP00000322373 | ENSP00000264779 | pleckstrin homology domain containing, family F (with FYVE domain) member 2 | GC-rich promoter binding protein 1; Functions as a GC-rich promoter-specific transactivating transcription factor (By similarity) | 0.461 |
| SAP130 | GPBP1 | ENSP00000350333 | ENSP00000264779 | Sin3A-associated protein, 130kDa; Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes | GC-rich promoter binding protein 1; Functions as a GC-rich promoter-specific transactivating transcription factor (By similarity) | 0.538 |
| TMEM134 | GPBP1 | ENSP00000312615 | ENSP00000264779 | transmembrane protein 134 | GC-rich promoter binding protein 1; Functions as a GC-rich promoter-specific transactivating transcription factor (By similarity) | 0.451 |
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