Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | MIER2 | mesoderm induction early response 1, family member 2; Transcriptional repressor (By similarity) (545 aa) | ||||||||||||
Predicted Functional Partners:
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 | MRGBP | MRG/MORF4L binding protein; Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative [...] (204 aa) |
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0.666 | ||||||||||
 | MBD3L4 | methyl-CpG binding domain protein 3-like 4 (208 aa) |
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0.566 | ||||||||||
 | ENSG00000204752 | Uncharacterized protein (81 aa) |
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0.566 | ||||||||||
 | MBD3L3 | methyl-CpG binding domain protein 3-like 3 (208 aa) |
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0.566 | ||||||||||
 | MBD3L5 | methyl-CpG binding domain protein 3-like 5 (208 aa) |
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0.566 | ||||||||||
 | OR4F17 | olfactory receptor, family 4, subfamily F, member 17; Odorant receptor (Potential) (305 aa) |
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0.535 | ||||||||||
 | ZNF557 | zinc finger protein 557; May be involved in transcriptional regulation (430 aa) |
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0.506 | ||||||||||
 | POM121C | POM121 transmembrane nucleoporin C; Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL) (987 aa) |
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0.487 | ||||||||||
 | POM121 | POM121 transmembrane nucleoporin (984 aa) |
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0.487 | ||||||||||
 | KIAA0586 | KIAA0586; Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity) (1472 aa) |
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0.487 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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