node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CAV1 | SCARB2 | ENSP00000339191 | ENSP00000264896 | caveolin 1, caveolae protein, 22kDa; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)- mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3- dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway | scavenger receptor class B, member 2; Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting | 0.863 |
CD320 | SCARB2 | ENSP00000301458 | ENSP00000264896 | CD320 molecule; Germinal center-B (GC-B) cells differentiate into memory B-cells and plasma cells (PC) through interaction with T-cells and follicular dendritic cells (FDC). CD320 augments the proliferation of PC precursors generated by IL-10. Receptor for the cellular uptake of transcobalamin bound cobalamin | scavenger receptor class B, member 2; Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting | 0.712 |
CD63 | SCARB2 | ENSP00000257857 | ENSP00000264896 | CD63 molecule; This antigen is associated with early stages of melanoma tumor progression. May play a role in growth regulation | scavenger receptor class B, member 2; Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting | 0.882 |
CDH2 | SCARB2 | ENSP00000269141 | ENSP00000264896 | cadherin 2, type 1, N-cadherin (neuronal); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density (By similarity) | scavenger receptor class B, member 2; Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting | 0.800 |
KCTD7 | SCARB2 | ENSP00000398177 | ENSP00000264896 | potassium channel tetramerisation domain containing 7; Rab effector protein acting as linker between gamma- adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase (By similarity) | scavenger receptor class B, member 2; Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting | 0.747 |
PGRMC1 | SCARB2 | ENSP00000217971 | ENSP00000264896 | progesterone receptor membrane component 1; Receptor for progesterone (By similarity) | scavenger receptor class B, member 2; Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting | 0.812 |
SCARB2 | CAV1 | ENSP00000264896 | ENSP00000339191 | scavenger receptor class B, member 2; Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting | caveolin 1, caveolae protein, 22kDa; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)- mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3- dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway | 0.863 |
SCARB2 | CD320 | ENSP00000264896 | ENSP00000301458 | scavenger receptor class B, member 2; Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting | CD320 molecule; Germinal center-B (GC-B) cells differentiate into memory B-cells and plasma cells (PC) through interaction with T-cells and follicular dendritic cells (FDC). CD320 augments the proliferation of PC precursors generated by IL-10. Receptor for the cellular uptake of transcobalamin bound cobalamin | 0.712 |
SCARB2 | CD63 | ENSP00000264896 | ENSP00000257857 | scavenger receptor class B, member 2; Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting | CD63 molecule; This antigen is associated with early stages of melanoma tumor progression. May play a role in growth regulation | 0.882 |
SCARB2 | CDH2 | ENSP00000264896 | ENSP00000269141 | scavenger receptor class B, member 2; Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting | cadherin 2, type 1, N-cadherin (neuronal); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density (By similarity) | 0.800 |
SCARB2 | KCTD7 | ENSP00000264896 | ENSP00000398177 | scavenger receptor class B, member 2; Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting | potassium channel tetramerisation domain containing 7; Rab effector protein acting as linker between gamma- adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase (By similarity) | 0.747 |
SCARB2 | PGRMC1 | ENSP00000264896 | ENSP00000217971 | scavenger receptor class B, member 2; Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting | progesterone receptor membrane component 1; Receptor for progesterone (By similarity) | 0.812 |
SCARB2 | SMS | ENSP00000264896 | ENSP00000385746 | scavenger receptor class B, member 2; Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting | spermine synthase; Catalyzes the production of spermine from spermidine and decarboxylated S-adenosylmethionine (dcSAM) | 0.749 |
SCARB2 | THBS1 | ENSP00000264896 | ENSP00000260356 | scavenger receptor class B, member 2; Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting | thrombospondin 1; Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties | 0.786 |
SCARB2 | TLR4 | ENSP00000264896 | ENSP00000363089 | scavenger receptor class B, member 2; Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting | toll-like receptor 4 | 0.692 |
SCARB2 | TSPAN3 | ENSP00000264896 | ENSP00000267970 | scavenger receptor class B, member 2; Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting | tetraspanin 3; Regulates the proliferation and migration of oligodendrocytes, a process essential for normal myelination and repair (By similarity) | 0.687 |
SMS | SCARB2 | ENSP00000385746 | ENSP00000264896 | spermine synthase; Catalyzes the production of spermine from spermidine and decarboxylated S-adenosylmethionine (dcSAM) | scavenger receptor class B, member 2; Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting | 0.749 |
THBS1 | SCARB2 | ENSP00000260356 | ENSP00000264896 | thrombospondin 1; Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Binds heparin. May play a role in dentinogenesis and/or maintenance of dentin and dental pulp (By similarity). Ligand for CD36 mediating antiangiogenic properties | scavenger receptor class B, member 2; Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting | 0.786 |
TLR4 | SCARB2 | ENSP00000363089 | ENSP00000264896 | toll-like receptor 4 | scavenger receptor class B, member 2; Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting | 0.692 |
TSPAN3 | SCARB2 | ENSP00000267970 | ENSP00000264896 | tetraspanin 3; Regulates the proliferation and migration of oligodendrocytes, a process essential for normal myelination and repair (By similarity) | scavenger receptor class B, member 2; Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting | 0.687 |