PDE8B protein (Homo sapiens) - STRING network view

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PDE8B

phosphodiesterase 8B; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in specific signaling in the thyroid gland (885 aa)

Predicted Functional Partners:

GNAS

0.948

ADCY9

0.913

ADCY3

0.909

ADCY4

0.907

ADCY6

0.905

ADCY5

0.905

ADCY2

0.905

ADCY1

0.905

ADCY8

0.905

ADCY7

0.905

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY1	ADCY2	ENSP00000297323	ENSP00000342952	adenylate cyclase 1 (brain); This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning	adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase	0.962
ADCY1	ADCY3	ENSP00000297323	ENSP00000260600	adenylate cyclase 1 (brain); This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning	adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration	0.911
ADCY1	ADCY4	ENSP00000297323	ENSP00000312126	adenylate cyclase 1 (brain); This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning	adenylate cyclase 4; This is a membrane-bound, calmodulin-insensitive adenylyl cyclase (By similarity)	0.915
ADCY1	ADCY5	ENSP00000297323	ENSP00000419361	adenylate cyclase 1 (brain); This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning	adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase	0.908
ADCY1	ADCY6	ENSP00000297323	ENSP00000311405	adenylate cyclase 1 (brain); This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning	adenylate cyclase 6; Membrane-bound, calcium-inhibitable adenylyl cyclase (By similarity)	0.907
ADCY1	ADCY7	ENSP00000297323	ENSP00000254235	adenylate cyclase 1 (brain); This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning	adenylate cyclase 7; This is a membrane-bound, calcium-inhibitable adenylyl cyclase	0.924
ADCY1	ADCY8	ENSP00000297323	ENSP00000286355	adenylate cyclase 1 (brain); This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning	adenylate cyclase 8 (brain); This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence (By similarity)	0.910
ADCY1	ADCY9	ENSP00000297323	ENSP00000294016	adenylate cyclase 1 (brain); This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning	adenylate cyclase 9; May play a fundamental role in situations where fine interplay between intracellular calcium and cAMP determines the cellular function. May be a physiologically relevant docking site for calcineurin (By similarity)	0.928
ADCY1	GNAS	ENSP00000297323	ENSP00000360141	adenylate cyclase 1 (brain); This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning	GNAS complex locus; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(s) protein is involved in hormonal regulation of adenylate cyclase- it activates the cyclase in response to beta-adrenergic stimuli. XLas isoforms interact with the same set of receptors as Gnas isoforms (By similarity)	0.961
ADCY1	PDE8B	ENSP00000297323	ENSP00000264917	adenylate cyclase 1 (brain); This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning	phosphodiesterase 8B; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in specific signaling in the thyroid gland	0.905
ADCY2	ADCY1	ENSP00000342952	ENSP00000297323	adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase	adenylate cyclase 1 (brain); This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning	0.962
ADCY2	ADCY3	ENSP00000342952	ENSP00000260600	adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase	adenylate cyclase 3; Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration	0.912
ADCY2	ADCY4	ENSP00000342952	ENSP00000312126	adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase	adenylate cyclase 4; This is a membrane-bound, calmodulin-insensitive adenylyl cyclase (By similarity)	0.903
ADCY2	ADCY5	ENSP00000342952	ENSP00000419361	adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase	adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase	0.964
ADCY2	ADCY6	ENSP00000342952	ENSP00000311405	adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase	adenylate cyclase 6; Membrane-bound, calcium-inhibitable adenylyl cyclase (By similarity)	0.920
ADCY2	ADCY7	ENSP00000342952	ENSP00000254235	adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase	adenylate cyclase 7; This is a membrane-bound, calcium-inhibitable adenylyl cyclase	0.903
ADCY2	ADCY8	ENSP00000342952	ENSP00000286355	adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase	adenylate cyclase 8 (brain); This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence (By similarity)	0.917
ADCY2	ADCY9	ENSP00000342952	ENSP00000294016	adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase	adenylate cyclase 9; May play a fundamental role in situations where fine interplay between intracellular calcium and cAMP determines the cellular function. May be a physiologically relevant docking site for calcineurin (By similarity)	0.931
ADCY2	GNAS	ENSP00000342952	ENSP00000360141	adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase	GNAS complex locus; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(s) protein is involved in hormonal regulation of adenylate cyclase- it activates the cyclase in response to beta-adrenergic stimuli. XLas isoforms interact with the same set of receptors as Gnas isoforms (By similarity)	0.990
ADCY2	PDE8B	ENSP00000342952	ENSP00000264917	adenylate cyclase 2 (brain); This is a membrane-bound, calmodulin-insensitive adenylyl cyclase	phosphodiesterase 8B; Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in specific signaling in the thyroid gland	0.905

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