node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CYC1 | FH | ENSP00000317159 | ENSP00000355518 | cytochrome c-1; This is the heme-containing component of the cytochrome b-c1 complex, which accepts electrons from Rieske protein and transfers electrons to cytochrome c in the mitochondrial respiratory chain | fumarate hydratase; Also acts as a tumor suppressor | 0.550 |
CYC1 | SDHA | ENSP00000317159 | ENSP00000264932 | cytochrome c-1; This is the heme-containing component of the cytochrome b-c1 complex, which accepts electrons from Rieske protein and transfers electrons to cytochrome c in the mitochondrial respiratory chain | succinate dehydrogenase complex, subunit A, flavoprotein (Fp); Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Can act as a tumor suppressor | 0.983 |
CYC1 | SDHB | ENSP00000317159 | ENSP00000364649 | cytochrome c-1; This is the heme-containing component of the cytochrome b-c1 complex, which accepts electrons from Rieske protein and transfers electrons to cytochrome c in the mitochondrial respiratory chain | succinate dehydrogenase complex, subunit B, iron sulfur (Ip); Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) | 0.991 |
CYC1 | SDHC | ENSP00000317159 | ENSP00000356953 | cytochrome c-1; This is the heme-containing component of the cytochrome b-c1 complex, which accepts electrons from Rieske protein and transfers electrons to cytochrome c in the mitochondrial respiratory chain | succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) | 0.974 |
CYC1 | SDHD | ENSP00000317159 | ENSP00000364699 | cytochrome c-1; This is the heme-containing component of the cytochrome b-c1 complex, which accepts electrons from Rieske protein and transfers electrons to cytochrome c in the mitochondrial respiratory chain | succinate dehydrogenase complex, subunit D, integral membrane protein; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (By similarity) | 0.955 |
CYC1 | SUCLA2 | ENSP00000317159 | ENSP00000367923 | cytochrome c-1; This is the heme-containing component of the cytochrome b-c1 complex, which accepts electrons from Rieske protein and transfers electrons to cytochrome c in the mitochondrial respiratory chain | succinate-CoA ligase, ADP-forming, beta subunit; Catalyzes the ATP-dependent ligation of succinate and CoA to form succinyl-CoA (By similarity) | 0.411 |
CYC1 | SUCLG1 | ENSP00000317159 | ENSP00000377446 | cytochrome c-1; This is the heme-containing component of the cytochrome b-c1 complex, which accepts electrons from Rieske protein and transfers electrons to cytochrome c in the mitochondrial respiratory chain | succinate-CoA ligase, alpha subunit; Catalyzes the ATP- or GTP-dependent ligation of succinate and CoA to form succinyl-CoA. The nature of the beta subunit determines the nucleotide specificity (By similarity) | 0.821 |
CYC1 | UQCRFS1 | ENSP00000317159 | ENSP00000306397 | cytochrome c-1; This is the heme-containing component of the cytochrome b-c1 complex, which accepts electrons from Rieske protein and transfers electrons to cytochrome c in the mitochondrial respiratory chain | ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis | 0.999 |
FH | CYC1 | ENSP00000355518 | ENSP00000317159 | fumarate hydratase; Also acts as a tumor suppressor | cytochrome c-1; This is the heme-containing component of the cytochrome b-c1 complex, which accepts electrons from Rieske protein and transfers electrons to cytochrome c in the mitochondrial respiratory chain | 0.550 |
FH | SDHA | ENSP00000355518 | ENSP00000264932 | fumarate hydratase; Also acts as a tumor suppressor | succinate dehydrogenase complex, subunit A, flavoprotein (Fp); Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Can act as a tumor suppressor | 0.981 |
FH | SDHB | ENSP00000355518 | ENSP00000364649 | fumarate hydratase; Also acts as a tumor suppressor | succinate dehydrogenase complex, subunit B, iron sulfur (Ip); Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) | 0.986 |
FH | SDHC | ENSP00000355518 | ENSP00000356953 | fumarate hydratase; Also acts as a tumor suppressor | succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) | 0.974 |
FH | SDHD | ENSP00000355518 | ENSP00000364699 | fumarate hydratase; Also acts as a tumor suppressor | succinate dehydrogenase complex, subunit D, integral membrane protein; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (By similarity) | 0.968 |
FH | SUCLA2 | ENSP00000355518 | ENSP00000367923 | fumarate hydratase; Also acts as a tumor suppressor | succinate-CoA ligase, ADP-forming, beta subunit; Catalyzes the ATP-dependent ligation of succinate and CoA to form succinyl-CoA (By similarity) | 0.755 |
FH | SUCLG1 | ENSP00000355518 | ENSP00000377446 | fumarate hydratase; Also acts as a tumor suppressor | succinate-CoA ligase, alpha subunit; Catalyzes the ATP- or GTP-dependent ligation of succinate and CoA to form succinyl-CoA. The nature of the beta subunit determines the nucleotide specificity (By similarity) | 0.801 |
FH | SUCLG2 | ENSP00000355518 | ENSP00000419325 | fumarate hydratase; Also acts as a tumor suppressor | succinate-CoA ligase, GDP-forming, beta subunit; Catalyzes the GTP-dependent ligation of succinate and CoA to form succinyl-CoA (By similarity) | 0.651 |
FH | UQCRFS1 | ENSP00000355518 | ENSP00000306397 | fumarate hydratase; Also acts as a tumor suppressor | ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis | 0.450 |
SDHA | CYC1 | ENSP00000264932 | ENSP00000317159 | succinate dehydrogenase complex, subunit A, flavoprotein (Fp); Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Can act as a tumor suppressor | cytochrome c-1; This is the heme-containing component of the cytochrome b-c1 complex, which accepts electrons from Rieske protein and transfers electrons to cytochrome c in the mitochondrial respiratory chain | 0.983 |
SDHA | FH | ENSP00000264932 | ENSP00000355518 | succinate dehydrogenase complex, subunit A, flavoprotein (Fp); Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Can act as a tumor suppressor | fumarate hydratase; Also acts as a tumor suppressor | 0.981 |
SDHA | SDHAF2 | ENSP00000264932 | ENSP00000301761 | succinate dehydrogenase complex, subunit A, flavoprotein (Fp); Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Can act as a tumor suppressor | succinate dehydrogenase complex assembly factor 2; Required for insertion of FAD cofactor into SDHA, the catalytic subunit of succinate dehydrogenase (SDH). SDH is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). In is unclear whether it participates in the chemistry of FAD attachment (enzymatic function) or acts as a chaperone that maintains SDHA in a conformation that is susceptible to autocatalytic FAD attachment | 0.994 |