| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CRMP1 | EVC | ENSP00000321606 | ENSP00000264956 | collapsin response mediator protein 1; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration | Ellis van Creveld syndrome; Acts as a positive mediator of Hedgehog signaling indispensable for normal endochondral growth and skeletal development (By similarity) | 0.742 |
| CRMP1 | EVC2 | ENSP00000321606 | ENSP00000342144 | collapsin response mediator protein 1; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration | Ellis van Creveld syndrome 2; Positive regulator of the hedgehog signaling pathway (By similarity). Plays a critical role in bone formation and skeletal development | 0.659 |
| CRMP1 | MSX1 | ENSP00000321606 | ENSP00000372170 | collapsin response mediator protein 1; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration | msh homeobox 1; Acts as a transcriptional repressor. May play a role in limb-pattern formation. Acts in cranofacial development and specifically in odontogenesis. Expression in the developing nail bed mesenchyme is important for nail plate thickness and integrity | 0.403 |
| CRMP1 | NSG1 | ENSP00000321606 | ENSP00000381049 | collapsin response mediator protein 1; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration | Neuron-specific protein family member 1 | 0.727 |
| CRMP1 | STX18 | ENSP00000321606 | ENSP00000305810 | collapsin response mediator protein 1; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration | syntaxin 18; Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER | 0.667 |
| DYNC2H1 | EVC | ENSP00000381167 | ENSP00000264956 | dynein, cytoplasmic 2, heavy chain 1 | Ellis van Creveld syndrome; Acts as a positive mediator of Hedgehog signaling indispensable for normal endochondral growth and skeletal development (By similarity) | 0.510 |
| DYNC2H1 | FAN1 | ENSP00000381167 | ENSP00000354497 | dynein, cytoplasmic 2, heavy chain 1 | FANCD2/FANCI-associated nuclease 1; Nuclease required for maintenance of chromosomal stability. Plays a key role in DNA repair of DNA interstrand cross-links (ICL) by being recruited to sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL- induced DNA breaks by being required for efficient homologous recombination, possibly in the resolution of homologous recombination intermediates. Not involved in DNA double-strand breaks resection. Has both endonuclease activity toward 5’-flaps and 5’-exonuclease activity- may act in concert with the 3’-flap- speci [...] | 0.517 |
| DYNC2H1 | IFT80 | ENSP00000381167 | ENSP00000312778 | dynein, cytoplasmic 2, heavy chain 1 | intraflagellar transport 80 homolog (Chlamydomonas); Component of the intraflagellar transport (IFT) complex B, which is essential for the development and maintenance of motile and sensory cilia | 0.866 |
| DYNC2H1 | MTMR10 | ENSP00000381167 | ENSP00000402537 | dynein, cytoplasmic 2, heavy chain 1 | myotubularin related protein 10; Probable pseudophosphatase. Contains a Glu residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Potential) | 0.609 |
| EVC | CRMP1 | ENSP00000264956 | ENSP00000321606 | Ellis van Creveld syndrome; Acts as a positive mediator of Hedgehog signaling indispensable for normal endochondral growth and skeletal development (By similarity) | collapsin response mediator protein 1; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration | 0.742 |
| EVC | DYNC2H1 | ENSP00000264956 | ENSP00000381167 | Ellis van Creveld syndrome; Acts as a positive mediator of Hedgehog signaling indispensable for normal endochondral growth and skeletal development (By similarity) | dynein, cytoplasmic 2, heavy chain 1 | 0.510 |
| EVC | EVC2 | ENSP00000264956 | ENSP00000342144 | Ellis van Creveld syndrome; Acts as a positive mediator of Hedgehog signaling indispensable for normal endochondral growth and skeletal development (By similarity) | Ellis van Creveld syndrome 2; Positive regulator of the hedgehog signaling pathway (By similarity). Plays a critical role in bone formation and skeletal development | 0.814 |
| EVC | FAN1 | ENSP00000264956 | ENSP00000354497 | Ellis van Creveld syndrome; Acts as a positive mediator of Hedgehog signaling indispensable for normal endochondral growth and skeletal development (By similarity) | FANCD2/FANCI-associated nuclease 1; Nuclease required for maintenance of chromosomal stability. Plays a key role in DNA repair of DNA interstrand cross-links (ICL) by being recruited to sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL- induced DNA breaks by being required for efficient homologous recombination, possibly in the resolution of homologous recombination intermediates. Not involved in DNA double-strand breaks resection. Has both endonuclease activity toward 5’-flaps and 5’-exonuclease activity- may act in concert with the 3’-flap- speci [...] | 0.606 |
| EVC | HMX1 | ENSP00000264956 | ENSP00000383516 | Ellis van Creveld syndrome; Acts as a positive mediator of Hedgehog signaling indispensable for normal endochondral growth and skeletal development (By similarity) | H6 family homeobox 1; DNA-binding protein that binds to the 5’-CAAG-3’ core sequence. May function as a transcriptional repressor. Seems to act as a transcriptional antagonist of NKX2-5. May play an important role in the development of craniofacial structures such as the eye and ear | 0.489 |
| EVC | IFT80 | ENSP00000264956 | ENSP00000312778 | Ellis van Creveld syndrome; Acts as a positive mediator of Hedgehog signaling indispensable for normal endochondral growth and skeletal development (By similarity) | intraflagellar transport 80 homolog (Chlamydomonas); Component of the intraflagellar transport (IFT) complex B, which is essential for the development and maintenance of motile and sensory cilia | 0.476 |
| EVC | MSX1 | ENSP00000264956 | ENSP00000372170 | Ellis van Creveld syndrome; Acts as a positive mediator of Hedgehog signaling indispensable for normal endochondral growth and skeletal development (By similarity) | msh homeobox 1; Acts as a transcriptional repressor. May play a role in limb-pattern formation. Acts in cranofacial development and specifically in odontogenesis. Expression in the developing nail bed mesenchyme is important for nail plate thickness and integrity | 0.586 |
| EVC | MTMR10 | ENSP00000264956 | ENSP00000402537 | Ellis van Creveld syndrome; Acts as a positive mediator of Hedgehog signaling indispensable for normal endochondral growth and skeletal development (By similarity) | myotubularin related protein 10; Probable pseudophosphatase. Contains a Glu residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Potential) | 0.667 |
| EVC | NSG1 | ENSP00000264956 | ENSP00000381049 | Ellis van Creveld syndrome; Acts as a positive mediator of Hedgehog signaling indispensable for normal endochondral growth and skeletal development (By similarity) | Neuron-specific protein family member 1 | 0.685 |
| EVC | STX18 | ENSP00000264956 | ENSP00000305810 | Ellis van Creveld syndrome; Acts as a positive mediator of Hedgehog signaling indispensable for normal endochondral growth and skeletal development (By similarity) | syntaxin 18; Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER | 0.609 |
| EVC2 | CRMP1 | ENSP00000342144 | ENSP00000321606 | Ellis van Creveld syndrome 2; Positive regulator of the hedgehog signaling pathway (By similarity). Plays a critical role in bone formation and skeletal development | collapsin response mediator protein 1; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration | 0.659 |
Share
