| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ASTE1 | C4orf6 | ENSP00000264992 | ENSP00000195455 | asteroid homolog 1 (Drosophila); Possible role in EGF receptor signaling (By similarity) | chromosome 4 open reading frame 6 | 0.414 |
| ASTE1 | CACNA1B | ENSP00000264992 | ENSP00000360406 | asteroid homolog 1 (Drosophila); Possible role in EGF receptor signaling (By similarity) | calcium channel, voltage-dependent, N type, alpha 1B subunit; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the ’high-voltage activated’ (HVA) group and are blocked by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin- IIIA (omega-Aga-IIIA). [...] | 0.534 |
| ASTE1 | CACNA1E | ENSP00000264992 | ENSP00000356545 | asteroid homolog 1 (Drosophila); Possible role in EGF receptor signaling (By similarity) | calcium channel, voltage-dependent, R type, alpha 1E subunit; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the ’high-voltage activated’ (HVA) group and are blocked by nickel, and partially by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however ins [...] | 0.506 |
| ASTE1 | LDOC1L | ENSP00000264992 | ENSP00000340434 | asteroid homolog 1 (Drosophila); Possible role in EGF receptor signaling (By similarity) | leucine zipper, down-regulated in cancer 1-like | 0.408 |
| ASTE1 | NUDT16 | ENSP00000264992 | ENSP00000422375 | asteroid homolog 1 (Drosophila); Possible role in EGF receptor signaling (By similarity) | nudix (nucleoside diphosphate linked moiety X)-type motif 16; RNA-binding and decapping enzyme that catalyzes the cleavage of the cap structure of snoRNAs and mRNAs in a metal- dependent manner. Part of the U8 snoRNP complex that is required for the accumulation of mature 5.8S and 28S rRNA. Has diphosphatase activity and removes m7G and/or m227G caps from U8 snoRNA and leaves a 5’monophosphate on the RNA. Catalyzes also the cleavage of the cap structure on mRNAs. Does not hydrolyze cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG). Also hydrolysis m7G- and [...] | 0.457 |
| ASTE1 | PAGE2 | ENSP00000264992 | ENSP00000364107 | asteroid homolog 1 (Drosophila); Possible role in EGF receptor signaling (By similarity) | P antigen family, member 2 (prostate associated) | 0.505 |
| ASTE1 | PAGE3 | ENSP00000264992 | ENSP00000364089 | asteroid homolog 1 (Drosophila); Possible role in EGF receptor signaling (By similarity) | P antigen family, member 3 (prostate associated) | 0.407 |
| ASTE1 | PLSCR5 | ENSP00000264992 | ENSP00000390111 | asteroid homolog 1 (Drosophila); Possible role in EGF receptor signaling (By similarity) | phospholipid scramblase family, member 5 | 0.512 |
| ASTE1 | TAF1B | ENSP00000264992 | ENSP00000263663 | asteroid homolog 1 (Drosophila); Possible role in EGF receptor signaling (By similarity) | TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa; Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during trancription initiation such as preinitiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3 | 0.499 |
| ASTE1 | XRCC4 | ENSP00000264992 | ENSP00000342011 | asteroid homolog 1 (Drosophila); Possible role in EGF receptor signaling (By similarity) | X-ray repair complementing defective repair in Chinese hamster cells 4; Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends | 0.613 |
| C4orf6 | ASTE1 | ENSP00000195455 | ENSP00000264992 | chromosome 4 open reading frame 6 | asteroid homolog 1 (Drosophila); Possible role in EGF receptor signaling (By similarity) | 0.414 |
| CACNA1B | ASTE1 | ENSP00000360406 | ENSP00000264992 | calcium channel, voltage-dependent, N type, alpha 1B subunit; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the ’high-voltage activated’ (HVA) group and are blocked by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin- IIIA (omega-Aga-IIIA). [...] | asteroid homolog 1 (Drosophila); Possible role in EGF receptor signaling (By similarity) | 0.534 |
| CACNA1B | CACNA1E | ENSP00000360406 | ENSP00000356545 | calcium channel, voltage-dependent, N type, alpha 1B subunit; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the ’high-voltage activated’ (HVA) group and are blocked by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin- IIIA (omega-Aga-IIIA). [...] | calcium channel, voltage-dependent, R type, alpha 1E subunit; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the ’high-voltage activated’ (HVA) group and are blocked by nickel, and partially by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however ins [...] | 0.763 |
| CACNA1E | ASTE1 | ENSP00000356545 | ENSP00000264992 | calcium channel, voltage-dependent, R type, alpha 1E subunit; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the ’high-voltage activated’ (HVA) group and are blocked by nickel, and partially by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however ins [...] | asteroid homolog 1 (Drosophila); Possible role in EGF receptor signaling (By similarity) | 0.506 |
| CACNA1E | CACNA1B | ENSP00000356545 | ENSP00000360406 | calcium channel, voltage-dependent, R type, alpha 1E subunit; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the ’high-voltage activated’ (HVA) group and are blocked by nickel, and partially by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however ins [...] | calcium channel, voltage-dependent, N type, alpha 1B subunit; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the ’high-voltage activated’ (HVA) group and are blocked by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin- IIIA (omega-Aga-IIIA). [...] | 0.763 |
| LDOC1L | ASTE1 | ENSP00000340434 | ENSP00000264992 | leucine zipper, down-regulated in cancer 1-like | asteroid homolog 1 (Drosophila); Possible role in EGF receptor signaling (By similarity) | 0.408 |
| NUDT16 | ASTE1 | ENSP00000422375 | ENSP00000264992 | nudix (nucleoside diphosphate linked moiety X)-type motif 16; RNA-binding and decapping enzyme that catalyzes the cleavage of the cap structure of snoRNAs and mRNAs in a metal- dependent manner. Part of the U8 snoRNP complex that is required for the accumulation of mature 5.8S and 28S rRNA. Has diphosphatase activity and removes m7G and/or m227G caps from U8 snoRNA and leaves a 5’monophosphate on the RNA. Catalyzes also the cleavage of the cap structure on mRNAs. Does not hydrolyze cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG). Also hydrolysis m7G- and [...] | asteroid homolog 1 (Drosophila); Possible role in EGF receptor signaling (By similarity) | 0.457 |
| NUDT16 | PLSCR5 | ENSP00000422375 | ENSP00000390111 | nudix (nucleoside diphosphate linked moiety X)-type motif 16; RNA-binding and decapping enzyme that catalyzes the cleavage of the cap structure of snoRNAs and mRNAs in a metal- dependent manner. Part of the U8 snoRNP complex that is required for the accumulation of mature 5.8S and 28S rRNA. Has diphosphatase activity and removes m7G and/or m227G caps from U8 snoRNA and leaves a 5’monophosphate on the RNA. Catalyzes also the cleavage of the cap structure on mRNAs. Does not hydrolyze cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG). Also hydrolysis m7G- and [...] | phospholipid scramblase family, member 5 | 0.480 |
| PAGE2 | ASTE1 | ENSP00000364107 | ENSP00000264992 | P antigen family, member 2 (prostate associated) | asteroid homolog 1 (Drosophila); Possible role in EGF receptor signaling (By similarity) | 0.505 |
| PAGE3 | ASTE1 | ENSP00000364089 | ENSP00000264992 | P antigen family, member 3 (prostate associated) | asteroid homolog 1 (Drosophila); Possible role in EGF receptor signaling (By similarity) | 0.407 |
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