node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CNTN1 | TNC | ENSP00000325660 | ENSP00000265131 | contactin 1; Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurit [...] | tenascin C; Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6 | 0.971 |
EGFR | FGF2 | ENSP00000275493 | ENSP00000264498 | epidermal growth factor receptor | fibroblast growth factor 2 (basic) | 0.992 |
EGFR | MMP3 | ENSP00000275493 | ENSP00000299855 | epidermal growth factor receptor | matrix metallopeptidase 3 (stromelysin 1, progelatinase); Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase | 0.551 |
EGFR | PTK2 | ENSP00000275493 | ENSP00000341189 | epidermal growth factor receptor | PTK2 protein tyrosine kinase 2; Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; req [...] | 0.976 |
EGFR | RHOA | ENSP00000275493 | ENSP00000400175 | epidermal growth factor receptor | ras homolog family member A; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disor [...] | 0.970 |
EGFR | TNC | ENSP00000275493 | ENSP00000265131 | epidermal growth factor receptor | tenascin C; Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6 | 0.954 |
FGF2 | EGFR | ENSP00000264498 | ENSP00000275493 | fibroblast growth factor 2 (basic) | epidermal growth factor receptor | 0.992 |
FGF2 | MMP3 | ENSP00000264498 | ENSP00000299855 | fibroblast growth factor 2 (basic) | matrix metallopeptidase 3 (stromelysin 1, progelatinase); Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase | 0.913 |
FGF2 | PAX6 | ENSP00000264498 | ENSP00000368401 | fibroblast growth factor 2 (basic) | paired box 6; Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes | 0.933 |
FGF2 | PTK2 | ENSP00000264498 | ENSP00000341189 | fibroblast growth factor 2 (basic) | PTK2 protein tyrosine kinase 2; Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis, normal cardiomyocyte migration and proliferation, and normal heart development. Regulates axon growth and neuronal cell migration, axon branching and synapse formation; req [...] | 0.508 |
FGF2 | RHOA | ENSP00000264498 | ENSP00000400175 | fibroblast growth factor 2 (basic) | ras homolog family member A; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disor [...] | 0.560 |
FGF2 | SDC4 | ENSP00000264498 | ENSP00000361818 | fibroblast growth factor 2 (basic) | syndecan 4; Cell surface proteoglycan that bears heparan sulfate | 0.996 |
FGF2 | TNC | ENSP00000264498 | ENSP00000265131 | fibroblast growth factor 2 (basic) | tenascin C; Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6 | 0.971 |
MMP3 | EGFR | ENSP00000299855 | ENSP00000275493 | matrix metallopeptidase 3 (stromelysin 1, progelatinase); Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase | epidermal growth factor receptor | 0.551 |
MMP3 | FGF2 | ENSP00000299855 | ENSP00000264498 | matrix metallopeptidase 3 (stromelysin 1, progelatinase); Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase | fibroblast growth factor 2 (basic) | 0.913 |
MMP3 | SDC4 | ENSP00000299855 | ENSP00000361818 | matrix metallopeptidase 3 (stromelysin 1, progelatinase); Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase | syndecan 4; Cell surface proteoglycan that bears heparan sulfate | 0.932 |
MMP3 | TNC | ENSP00000299855 | ENSP00000265131 | matrix metallopeptidase 3 (stromelysin 1, progelatinase); Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase | tenascin C; Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6 | 0.957 |
NCAN | SDC4 | ENSP00000252575 | ENSP00000361818 | neurocan; May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid | syndecan 4; Cell surface proteoglycan that bears heparan sulfate | 0.914 |
NCAN | TNC | ENSP00000252575 | ENSP00000265131 | neurocan; May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid | tenascin C; Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6 | 0.961 |
NPSR1 | TNC | ENSP00000352839 | ENSP00000265131 | neuropeptide S receptor 1 | tenascin C; Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6 | 0.947 |