Full Link:
  • Version:
  • 10.0 (archived version)
STRINGSTRING
SLC35B2 SLC35B2 SLC26A1 SLC26A1 BPNT1 BPNT1 MTRR MTRR PAPSS2 PAPSS2 PAPSS1 PAPSS1 SUOX SUOX FLAD1 FLAD1 IMPAD1 IMPAD1 SLC35B3 SLC35B3 SLC26A2 SLC26A2
"PAPSS1" - 3'-phosphoadenosine 5'-phosphosulfate synthase 1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PAPSS13’-phosphoadenosine 5’-phosphosulfate synthase 1; Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5’-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3’-phosphoadenylylsulfate (PAPS- activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate- activation pathway. Also involved in the [...] (624 aa)    
Predicted Functional Partners:
PAPSS2
3’-phosphoadenosine 5’-phosphosulfate synthase 2; Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5’-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3’-phosphoadenylylsulfate (PAPS- activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate- activation pathway. May have a important [...] (619 aa)
score_image   score_image score_image   score_image score_image score_image 0.998
IMPAD1
inositol monophosphatase domain containing 1; May play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3’,5’-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation (By similarity) (359 aa)
score_image     score_image   score_image score_image   0.983
SLC26A2
solute carrier family 26 (sulfate transporter), member 2; Sulfate transporter. May play a role in endochondral bone formation (739 aa)
      score_image   score_image score_image   0.978
SLC35B3
solute carrier family 35, member B3; Mediates the transport of adenosine 3’-phospho 5’- phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. Compensates for the insufficient expression of SLC35B2/PAPST1 during the synthesis of sulfated glycoconjugates in the colon (401 aa)
          score_image score_image   0.965
SLC35B2
solute carrier family 35, member B2; Mediates the transport of adenosine 3’-phospho 5’- phosphosulfate (PAPS), from cytosol into Golgi. PAPS is a universal sulfuryl donor for sulfation events that take place in the Golgi. May indirectly participate in activation of the NF- kappa-B and MAPK pathways (432 aa)
          score_image score_image   0.960
FLAD1
FAD1 flavin adenine dinucleotide synthetase homolog (S. cerevisiae); Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme (587 aa)
score_image     score_image     score_image   0.951
SLC26A1
solute carrier family 26 (sulfate transporter), member 1; High affinity uptake of sulfate. Accepts oxalate, but not succinate as a cosubstrate (701 aa)
      score_image   score_image score_image   0.947
BPNT1
3’(2’), 5’-bisphosphate nucleotidase 1; Converts adenosine 3’-phosphate 5’-phosphosulfate (PAPS) to adenosine 5’-phosphosulfate (APS) and 3’(2’)-phosphoadenosine 5’- phosphate (PAP) to AMP. Has 1000-fold lower activity towards inositol 1,4-bisphosphate (Ins(1,4)P2) and inositol 1,3,4- trisphosphate (Ins(1,3,4)P3), but does not hydrolyze Ins(1)P, Ins(3,4)P2, Ins(1,3,4,5)P4 or InsP6 (308 aa)
          score_image score_image   0.947
SUOX
sulfite oxidase (545 aa)
          score_image score_image   0.931
MTRR
5-methyltetrahydrofolate-homocysteine methyltransferase reductase; Involved in the reductive regeneration of cob(I)alamin cofactor required for the maintenance of methionine synthase in a functional state (725 aa)
score_image     score_image score_image   score_image   0.928
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Server load: low (24%)